关键词: 肾病, 肠杆菌科, 综述

Abstract: 加速CKD进展。肠道菌群参与CKD发生发展的机制尚不明确，本文就CKD患者肠道菌群的变化及影响做一综述，希望通过调节肠道菌群延缓CKD进展以降低病死率。Normally the gut microbiota and the human body are mutually beneficial.Chronic kidney disease（CKD） contributes to the intestinal dysbiosis and impaired intestinal barrier resulting in bacterial translocation，increased production of uremic toxin and systemic inflammation，which accelerates the progression of CKD.The exact pathogenesis by which gut microbiota participates in the development of CKD is not clear.This paper reviews literature on the alterations and influences of gut microbiota in CKD in order to provide basis for delaying the progression of CKD and decreasing its mortality by modulating gut microbiota.

Key words: Nephrosis, Enterobacteriaceae, Review