关键词: 寻常痤疮, 物理治疗技术, 药物疗法, 联合, 治疗结果

Abstract: Objective 　To discuss the clinical efficacy of alternating red and blue light irradiation generated by light emitting diodes（ARBLIGLED），Mucopolysaccharide Polysulfate Cream（MPC） and Xihuang Capsule（XC） for moderate to severe facial acne，and to investigate the degree of improvement in quality of life in these patients.Methods　We enrolled 300 cases of moderate to severe facial acne from the Second Affiliated Hospital of Qiqihar Medical University and Heilongjiang Provincial Hospital from December 2015 to December 2016.Using random number table，we divided them into group A，group B and group C，with 100 in each，treated by ARBLIGLED combined with MPC and XC，ARBLIGLED combined with MPC，ARBLIGLED，respectively.Indicators for clinical efficacy include the number of inflammatory and non-inflammatory skin lesions，and levels of IgG，IgA，IgM，serum complement C3 and C4，IL-2，sIL-2R，and 4 sex hormones（follicle-stimulating hormone，luteinizing hormone，testosterone，estradiol）．Quality of life was assessed by SF-36.Results　After treatment，the number of both inflammatory and non-inflammatory skin lesions decreased significantly in all groups compared with baseline（P<0.05）；levels of IgG，C3，C4 and IL-2 were found to be significantly lower in group A（P<0.05）；the levels of 4 sex hormones were still similar in males or females of all groups（P>0.05）．Compared with other two groups，after treatment，group A achieved better clinical response，which was indicated by much less number of inflammatory and non-inflammatory skin lesions，and significantly lower levels of IgG，C3，C4 and IL-2（P<0.05）．After treatment，group A achieved the highest SF-36 scores，followed by groups B and C（P<0.05）．Conclusion　The combination regimen of ARBLIGLED，MPC and XC has significant effect on moderate to severe facial acne as indicated by much improved immune functions and quality of life.

Key words: Acne vulgaris；Physical therapy modalities；Drug therapy, combination；Treatment outcome