关键词: 卒中, 认知障碍, 血流动力学, 治疗结果

Abstract: Objective　To observe changes in intracranial blood flow in response to three different treatment regimens for non-dementia cognitive impairment（PSCI-ND） after stroke.Methods　The study cohort included 99 patients with PSCI-ND who were admitted to the Department of Neurology of the Fourth Hospital of Hebei Medical University from February 2010 to October 2016 and randomly divided into one of three groups on the basis of conventional drug therapy：a cerebellar fastigial nucleus（FNS） group （n=32），an oxiracetam group（n=32），and a nimodipine group（n=35）．Transcranial Doppler ultrasonography was performed before and after treatment in all three groups to measure and compare the average blood flow velocity（MFV） of the middle cerebral artery（MCA），anterior cerebral artery（ACA），posterior cerebral artery（PCA），and intracranial vertebral artery（IVA） to observe the occurrence of adverse reactions.Results　After treatment，the MFV of the MCA in the FNS group was higher than that of the oxiracetam and nimodipine groups（P<0.05）．After treatment，the MFV of the MCA in the oxiracetam group was not significantly different from that of the nimodipine group（P>0.05）．The MFV of the ACA，PCA，and IVA in the oxiracetam group after treatment was lower than in the FNS and nimodipine groups（P<0.05）．After treatment，the MFV of the ACA was higher in the FNS group than in nimodipine group（P<0.05）．The MFV of the arteries in the FNS and nimodipine groups after treatment was higher than that before treatment（P<0.05）．There was no significant difference in the MFV of each artery before and after treatment in the oxiracetam group（P>0.05）．There was no significant difference in the incidence of adverse reactions among the three groups（χ2=0.730，P>0.05）．Conclusion　FNS and nimodipine generally improved cerebral blood supply in patients with PSCI-ND，but not oxiracetam.

Key words: Stroke, Cognition disorders, Hemodynamics, Treatment outcome