Community pharmacy has significant advantages in curbing medication misuse and managing chronic diseases. Nevertheless, pharmacists encounter challenges such as complex job duties, inadequate professional knowledge, and low public awareness. Under the background of government support for innovating and expanding pharmacists' roles, the healthcare alliance has emerged as an ideal solution to the dilemma in community pharmacy.

This research devote to establish a community pharmacy studio to enhance the quality of community pharmacy services and the outcomes of chronic disease management based on the healthcare alliance model.

Three randomized controlled trials were implemented in three communities within a healthcare alliance from April 2023 to March 2024, while all control groups served as negative controls. In Trial one, 254 healthcare professionals were randomly and equally divided into two groups. The experimental 1 group received pharmaceutical literacy training, after which the outcomes were compared with those of the control 1 group. In Trial two, 540 residents were randomly divided into two groups, the experimental 2 group received services from the community pharmacy studio. Pharmaceutical literacy, medication adherence, pharmacist recognition, and service satisfaction were compared between the two groups. In Trial three, 118 chronic disease patients were randomly divided into two groups. The experimental 3 group received individualized medication guidance, and the rates of chronic disease indicator control were compared between the two groups. Data were collected through questionnaires, interviews, and medical record reviews and analyzed by SPSS 24.0 software.

Survey results indicated that the proportion of participants with high pharmaceutical literacy in the experimental 1 group (86.61%, 110/127) was significantly higher than in the control 1 group (68.50%, 87/127), showing a statistically significant difference (χ²=11.966, P<0.01). The research found that the experimental 2 group had a higher proportion of residents with high pharmaceutical literacy compared to the control 2 group (P<0.001), according to comprehensive assessment of community residents' pharmaceutical literacy and service satisfaction. Additionally, the proportion of community residents exhibiting high medication adherence was higher in the experimental 2 group compared to the control 2 group (P<0.05). Furthermore, respondents in the experimental 2 group were satisfied with the pharmacy studio, the degree of satisfaction was significantly higher than that in the control 2 group (P<0.001). Also, the experimental 2 group had a higher proportion of residents recognizing the professional the pharmacist team compared to the control 2 group (P<0.01). The experimental 3 group demonstrated a higher rate of achieving chronic disease control targets than the control 3 group, and a higher proportion of positive evaluations regarding the pharmacist's role compared to the control 3 group (P<0.05).

Supported by healthcare alliance, the community pharmacy studio model, effectively overcame the challenges of community pharmacy development, enhanced the quality of pharmacy services, improved outcomes of patient disease management, and set new standards for the future of community pharmacy. This model provides valuable insights and practical experience for the development and innovation of community pharmacy services in China.