慢性失眠障碍患者长期使用苯二氮䓬类药物停药的研究进展

doi:10.12114/j.issn.1007-9572.2022.0341

中国全科医学 ›› 2022, Vol. 25 ›› Issue (27): 3347-3351.DOI: 10.12114/j.issn.1007-9572.2022.0341

慢性失眠障碍患者长期使用苯二氮䓬类药物停药的研究进展

程金湘, 张丽萍, 宿长军^*()

710038　陕西省西安市，空军军医大学第二附属医院神经内科

收稿日期:2022-03-10 修回日期:2022-05-31 出版日期:2022-09-20 发布日期:2022-06-17
通讯作者: 宿长军
程金湘，张丽萍，宿长军.慢性失眠障碍患者长期使用苯二氮类药物停药的研究进展[J].中国全科医学，2022，25（27）：3347-3351.[www.chinagp.net]
作者贡献：程金湘提出研究思路，设计检索方案，负责论文撰写与修改；张丽萍负责论文起草、修改；宿长军负责文章的可行性分析及最终版本的修订，对文章整体负责，监督管理。
基金资助:
国家重点研发计划"常见多发病防治研究"专项(2021YFC2501400，2021YFC2501405)

Update on the Withdrawal from Long-term Use of Benzodiazepines in Patients with Chronic Insomnia Disorder

Jinxiang CHENG, Liping ZHANG, Changjun SU^*()

Department of Neurology, the Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China

Received:2022-03-10 Revised:2022-05-31 Published:2022-09-20 Online:2022-06-17
Contact: Changjun SU
About author:
CHENG J X, ZHANG L P, SU C J. Update on the withdrawal from long-term use of Benzodiazepines in patients with chronic insomnia disorder [J] . Chinese General Practice, 2022, 25 (27) : 3347-3351.

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摘要/Abstract

摘要： 苯二氮䓬类（BZDs）药物适用于慢性失眠障碍的短期治疗，长期大剂量使用可导致严重的不良反应。患者长期应用BZDs可产生耐受性和依赖性，突然停药可出现反跳现象和戒断症状，导致停药困难。因此本文整理分析了目前慢性失眠障碍患者长期使用BZDs停药的相关文献，分别从BZDs概述、停药时机和策略、停药治疗等方面进行综述，旨在为长期使用BZDs的慢性失眠障碍患者如何合理停用BZDs提供借鉴。

关键词: 睡眠障碍, 失眠症, 苯二氮?类, 停药, 戒断症状, 综述

Abstract:

Benzodiazepines (BZDs) are indicated for the short-term treatment of chronic insomnia disorder, since real-world use of them in large doses for a long time could cause serious side effects. Patients with long-term use of BZDs are prone to BZDs tolerance and dependence, but sudden withdrawal from BZDs can lead to rebound and withdrawal symptoms, resulting in difficulty in withdrawal. We reviewed recent studies about the withdrawal from long-term use of BZDs in chronic insomnia disorder patients, focusing on the overview of BZDs, timing and strategy of withdrawal, and treatment of withdrawal symptoms. Our review will contribute to enriching the ideas of appropriately discontinuing BZDs in chronic insomnia disorder patients with long-term use of BZDs.

Key words: Sleep disorders, Insomnia, Benzodiazepines, Discontinuation, Withdrawal symptoms, Review

程金湘,张丽萍,宿长军. 慢性失眠障碍患者长期使用苯二氮䓬类药物停药的研究进展[J]. 中国全科医学, 2022, 25(27): 3347-3351. DOI: 10.12114/j.issn.1007-9572.2022.0341.
Jinxiang CHENG,Liping ZHANG,Changjun SU. Update on the Withdrawal from Long-term Use of Benzodiazepines in Patients with Chronic Insomnia Disorder[J]. Chinese General Practice, 2022, 25(27): 3347-3351. DOI: 10.12114/j.issn.1007-9572.2022.0341.

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慢性失眠障碍患者长期使用苯二氮䓬类药物停药的研究进展

Update on the Withdrawal from Long-term Use of Benzodiazepines in Patients with Chronic Insomnia Disorder

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