线粒体转移在脑卒中后认知障碍中的研究进展

doi:10.12114/j.issn.1007-9572.2023.0162

中国全科医学 ›› 2023, Vol. 26 ›› Issue (30): 3833-3840.DOI: 10.12114/j.issn.1007-9572.2023.0162

线粒体转移在脑卒中后认知障碍中的研究进展

肖雨倩¹, 白艳杰²^,^*(), 王岩¹, 陈淑颖¹, 陈丽敏¹, 孙可心¹, 万俊¹

1．450046　河南省郑州市，河南中医药大学
2．450000　河南省郑州市，河南中医药大学第一附属医院

收稿日期:2023-02-25 修回日期:2023-04-10 出版日期:2023-10-20 发布日期:2023-04-20
通讯作者: 白艳杰
作者贡献：肖雨倩进行文章的构思与撰写，文章的可行性分析；王岩进行文献的检索与收集；陈淑颖、陈丽敏进行文献的分析与整理；孙可心、万俊进行论文修订；白艳杰负责文章的质量控制及审校、监督管理，并对文章整体负责。
基金资助:
国家重点研发计划(2018YFC1706004); 河南省中医药科学研究专项重点课题(20-21ZY1009); 河南省中医药传承与创新人才工程（仲景工程）中医药学科拔尖人才(CZ0237-08); 河南省科技攻关计划(222102310529); 河南省卫健委国家中医临床研究基地科研专项(2022JDZX005); 河南省中医药拔尖人才培养项目专项课题(2022ZYBJ07)

Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment

XIAO Yuqian¹, BAI Yanjie²^,^*(), WANG Yan¹, CHEN Shuying¹, CHEN Limin¹, SUN Kexin¹, WAN Jun¹

1. Henan University of Chinese Medicine, Zhengzhou 450046, China
2. The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, China

Received:2023-02-25 Revised:2023-04-10 Published:2023-10-20 Online:2023-04-20
Contact: BAI Yanjie

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摘要/Abstract

摘要： 脑卒中常导致持续性脑卒中后认知障碍（PSCI），主要表现为学习、记忆等方面的障碍。目前，PSCI发病机制尚不完全清楚，但与线粒体功能障碍密切相关，健康线粒体对神经元存活至关重要。近年来研究表明，细胞间线粒体转移可通过增加神经元活力、增强线粒体代谢、调控神经炎症等过程与脑卒中联系，从而改善认知障碍。本文概述了线粒体转移的机制以及细胞间线粒体转移在PSCI中的关键作用，并探讨了线粒体移植作为PSCI的新型治疗干预措施的效果，为其临床防治提供参考。

关键词: 卒中, 认知障碍, 线粒体转移, 隧道纳米管, 细胞外囊泡, 间隙连接, 综述

Abstract:

Stroke often leads to persistent post-stroke cognitive impairment (PSCI), which mainly manifests as impairment in learning and memory. The pathogenesis remains unclear as present, but it is closely related to mitochondrial dysfunction, and healthy mitochondria are essential for neuronal survival. Recent studies have shown that intercellular mitochondrial transfer can be linked to stroke through increasing neuronal viability, enhancing mitochondrial metabolism, and modulating neuroinflammation, thereby improving cognitive impairment. This review overviews the mechanisms of mitochondrial transfer and the key role of intercellular mitochondrial transfer in PSCI, and discusses that mitochondrial transplantation may serve as a novel therapeutic intervention for PSCI, providing references for its clinical management.

Key words: Stroke, Cognition disorders, Mitochondrial transfer, Tunneling nanotubes, Extracellular vesicles, Gap junction, Review

肖雨倩,白艳杰,王岩,等. 线粒体转移在脑卒中后认知障碍中的研究进展[J]. 中国全科医学, 2023, 26(30): 3833-3840. DOI: 10.12114/j.issn.1007-9572.2023.0162.
XIAO Yuqian,BAI Yanjie,WANG Yan, et al. Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment[J]. Chinese General Practice, 2023, 26(30): 3833-3840. DOI: 10.12114/j.issn.1007-9572.2023.0162.

图/表 2

图1 线粒体转移的主要机制注：TNT=隧道纳米管，Extracellular vesicles=细胞外囊泡，Gap junction=间隙连接，Astrocyte=星形胶质细胞，Damaged neuron=受损神经元，Healthy mitochondria=健康线粒体，Dysfunctional mitochondria=功能障碍线粒体。

Figure 1 The main mechanisms of mitochondrial transfer

表1 人工线粒体移植治疗PSCI的潜在靶点

Table 1 Potential targets for artificial mitochondrial transplantation for PSCI

线粒体来源	移植方法	效果	参考文献
间充质干细胞	动脉内注射	减少脑梗死面积	[42]
间充质干细胞	鼻腔内注射	提高认知功能	[62]
星型胶质细胞	静脉内注射	提高神经功能	[63]
小鼠肌肉细胞	脑室内注射	减少细胞凋亡	[65]
人淋巴细胞或大鼠脑细胞	前额叶皮质内注射	改善注意力缺陷	[66]

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线粒体转移在脑卒中后认知障碍中的研究进展

Research Progress of Mitochondrial Transfer in Post-stroke Cognitive Impairment

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