关键词: 糖尿病, 2型；晚期糖基化终末产物肽；葡糖耐量试验；维吾尔族；早期诊断；筛查

Abstract: Background　In view of increasing incidence and decreased age of onset of type 2 diabetes mellitus（T2MD），early screening for T2MD for getting a timely diagnosis is becoming ever-growing important.Some studies have found that serum advanced glycation end product peptides（AGE-P） are superior to glycosylated hemoglobin （HbA1c） in terms of early screening for T2MD.Objective　To explore the value of serum AGE-P in early screening for T2MD in Uygur population.Methods　A total of 1 100 Uygur health check-up examinees were recruited from People's Hospital of Xinjiang Uygur Autonomous Region from February 2018 to December 2019 and divided into diabetic group （n=75） and normal glucose tolerance group （n=1 025） by the results of an OGTT.Intergroup comparisons were performed in terms of age，waist circumference，BMI，diastolic blood pressure，systolic blood pressure，fasting plasma glucose （FPG），2-h postprandial plasma glucose （2 hPG），HbA1c，AGE-P，total cholesterol （TC） and triglyceride，high-density lipoprotein cholesterol （HDL-C） and low-density lipoprotein cholesterol （LDL-C），urea nitrogen，uric acid and serum creatinine.ROC curves of serum FPG，2 hPG，HbA1c and AGE-P in screening for T2DM were plotted.Results　Compared to those with normal glucose tolerance，diabetic cases had greater average age，and higher average BMI，waist circumference，DBP and SBP （P<0.05）.Moreover，they also demonstrated higher average levels of serum FPG，2 hPG，HbA1c，TC，triglyceride，and LDL-C（P<0.05）.However，serum levels of AGE-P，HDL-C，urea nitrogen，uric acid and serum creatinine were similar in the two groups （P>0.05）.In screening for T2DM，the Youden's index of serum FPG was 0.854，with 88.0% sensitivity and 97.4% specificity，and AUC of 0.957〔95%CI（0.943，0.968），Z=25.718，P<0.001〕.The Youden's index of serum 2 hPG was 0.814，with 82.7% sensitivity and 98.7% specificity，and AUC of 0.937〔95%CI（0.921，0.951），Z=21.222，P<0.001〕.The Youden's index of serum AGE-P was 0.055，with 74.7% sensitivity and 19.8% specificity，and AUC of 0.507〔95%CI（0.477，0.537），Z=0.203，P=0.839〕.Conclusion　The serum AGE-P level did not show a significant increase in Uygur population with T2DM，and it had lower specificity and Youden's index in screening for T2DM.So it is recommended to use traditional indicators，such as FPG and OGTT，instead of AGE-P for screening for T2DM in Uygur population.

Key words: Diabetes mellitus, type 2；Advanced glycation end products peptides；Glucose tolerance test；Uygur nationality；Early diagnosis；Screening