2010—2019年卒中后认知障碍相关研究的可视化分析

doi:10.12114/j.issn.1007-9572.2020.00.549

摘要/Abstract

摘要： 背景　卒中后认知障碍严重影响卒中患者各项功能的恢复，可导致生活质量下降和生存时间减少等一系列不良结果，已成为世界卒中相关研究和干预的热点。目的　分析2010—2019年卒中后认知障碍相关研究的现状和热点。方法　以Web of Science中的核心合集数据库为来源，检索2010—2019年卒中后认知障碍相关研究，应用CiteSpace软件对研究国家/地区、机构、作者、发表期刊、突现关键词进行分析。结果　2010—2019年卒中后认知障碍相关研究文献共3 603篇，发文量随时间推移呈持续增长趋势。美国是发文量（1 107篇）和中心性（0.25）均位居第一的国家。多伦多大学与哈佛大学分别为具有最高发文量（83篇）和最高中心性（0.15）的机构。加拿大多伦多大学的BLACK、德国慕尼黑大学的DICHGANS与美国加利福尼亚大学的DECARLI，无论是发文量还是中心性均居于前5名内，且与其他作者之间协作较多，具有较高的权威。Stroke、Neurology与J Neurol Neurosur PS是卒中后认知障碍相关研究领域内最具影响力的三大期刊。短暂性脑缺血发作、预测因子、Meta分析、白质高信号、氧化应激可能是未来卒中后认知障碍相关研究的前沿。结论　卒中后认知障碍是目前备受关注的研究方向。近几年研究趋势集中在相关机制方面。关键词短暂性脑缺血发作、预测因子、Meta分析、白质高信号、氧化应激是最新的研究前沿，应密切关注。

关键词: 卒中, 认知障碍, CiteSpace, 可视化

Abstract: Background　Post-stroke cognitive impairment seriously affects the recovery of various functions after stroke，and can lead to a series of adverse results，such as decreased quality of life and reduced survival time.Therefore，it has become a focus of stroke-related research and intervention.Objective　To explore the status of studies about post-stroke cognitive impairment published from 2010 to 2019 with a deep analysis of the covered hot topics.Methods　The studies about post-stroke cognitive impairment published during 2009—2019 were searched from databases on the kernel database of Web of Science platform.The data extracted from the eligible studies，such as author's country/region and institution，high-output authors，publication journals and burst keywords，were analysed with CiteSpace.Results　A total of 3 603 articles were included.The overall trend of the number of publications showed a continuous growth.The United States ranked first in terms of the number of articles （1 107） and centrality （0.25）.The University of Toronto was the institution with the highest number of articles （83）.And Harvard University was the institution with the highest centrality （0.15）.BLACK from the University of Toronto in Canada，DICHGANS from the University of Munich in Germany，and DECARLI from the University of California in the United States ranked among the top 5 in terms of the number of articles and centrality.In addition，they had more cooperations with other authors and had high authority.Stroke，Neurology and Journal of Neurology Neurosurgery and Psychiatry are the three most influential journals in the field of post-stroke cognitive impairment.Transient ischemic attack，predictors，Meta-analysis，white matter hyperintensity，and oxidative stress may be the frontiers of post-stroke cognitive impairment in the future.Conclusion　Post-stroke cognitive impairment is a subject of growing attention.A more recent emerging trend has focused on its mechanism.The keywords "transient ischemic attack" "predictors" "Meta analysis" "white matter hyperintensity" and "oxidative stress" may be the latest research frontiers meriting close attention.

Key words: Stroke, Cognition disorders, CiteSpace, Visualization

郝文雪,李瑞青,胡延超,等. 2010—2019年卒中后认知障碍相关研究的可视化分析[J]. 中国全科医学, 2021, 24(6): 759-764. DOI: 10.12114/j.issn.1007-9572.2020.00.549.
HAO Wenxue,LI Ruiqing,HU Yanchao, et al. Post-stroke Cognitive Impairment-related Studies in 2010—2019：a Visualization Review　[J]. Chinese General Practice, 2021, 24(6): 759-764. DOI: 10.12114/j.issn.1007-9572.2020.00.549.

参考文献

［1］MELLON L，BREWER L，HALL P，et al．Cognitive impairment six months after ischaemic stroke：a profile from the ASPIRE-S study［J］．BMC Neurol，2015，15：31．DOI：10.1186/s12883-015-0288-2.
［2］NARASIMHALU K，ANG S，DE SILVA D A，et al．Severity of CIND and MCI predict incidence of dementia in an ischemic stroke cohort［J］．Neurology，2009，73（22）：1866-1872．DOI：10.1212/WNL.0b013e3181c3fcb7.
［3］NYS G M，VAN ZANDVOORT M J，VAN DER WORP H B，et al．Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke［J］．J Neurol Sci，2006，247（2）：149-156．DOI：10.1016/j.jns.2006.04.005.
［4］LAWRENCE A J，PATEL B，MORRIS R G，et al．Mechanisms of cognitive impairment in cerebral small vessel disease：multimodal MRI results from the St George's cognition and neuroimaging in stroke （SCANS） study［J］．PLoS One，2013，8（4）：e61014．DOI：10.1371/journal.pone.0061014.
［5］BENJAMIN P，LAWRENCE A J，LAMBERT C，et al．Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease［J］．Neuroimage Clin，2014，4：828-837．DOI：10.1016/j.nicl.2014.05.009.
［6］BENJAMIN P，TRIPPIER S，LAWRENCE A J，et al．Lacunar infarcts，but not perivascular spaces，are predictors of cognitive decline in cerebral small-vessel disease［J］．Stroke，2018，49（3）：586-593．DOI：10.1161/strokeaha.117.017526.
［7］ROSENBAUM HALEVI D，BURSAW A W，KARAMCHANDANI R R，et al．Cognitive deficits in acute mild ischemic stroke and TIA and effects of rt-PA［J］．Ann Clin Transl Neurol，2019，6（3）：466-474．DOI：10.1002/acn3.719.
［8］SIVAKUMAR L，KATE M，JEERAKATHIL T，et al．Serial Montreal cognitive assessments demonstrate reversible cognitive impairment in patients with acute transient ischemic attack and minor stroke［J］．Stroke，2014，45（6）：1709-1715．DOI：10.1161/STROKEAHA.114.004726.
［9］BIVARD A，LILLICRAP T，MARÉCHAL B，et al．Transient ischemic attack results in delayed brain atrophy and cognitive decline［J］．Stroke，2018，49（2）：384-390．DOI：10.1161/STROKEAHA.117.019276.
［10］ARBA F，QUINN T J，HANKEY G J，et al．Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack［J］．Int J Stroke，2018，13（1）：47-56．DOI：10.1177/1747493016666091.
［11］MUNSCH F，SAGNIER S，ASSELINEAU J，et al．Stroke location is an independent predictor of cognitive outcome［J］．Stroke，2016，47（1）：66-73．DOI：10.1161/STROKEAHA.115.011242.
［12］HAGBERG G，FURE B，THOMMESSEN B，et al．Predictors for favorable cognitive outcome post-stroke：a-seven-year follow-up study［J］．Dement Geriatr Cogn Disord，2019，48（1/2）：45-55．DOI：10.1159/000501850.
［13］QIAN L，DING L D，CHENG L Q，et al．Early biomarkers for post-stroke cognitive impairment［J］．J Neurol，2012，259（10）：2111-2118．DOI：10.1007/s00415-012-6465-y.
［14］BUNEVICIUS A，KAZLAUSKAS H，RASKAUSKIENE N，et al．Ischemic stroke functional outcomes are independently associated with C-reactive protein concentrations and cognitive outcomes with triiodothyronine concentrations：a pilot study［J］．Endocrine，2014，45（2）：213-220．DOI：10.1007/s12020-013-9958-2.
［15］IRIMIE C A，VÂRCIU M，IRIMIE M，et al．C-reactive protein and T3：new prognostic factors in acute ischemic stroke［J］．J Stroke Cerebrovasc Dis，2018，27（10）：2731-2737．DOI：10.1016/j.jstrokecerebrovasdis.2018.05.047.
［16］LUND H，BRUNNHUBER K，JUHL C，et al．Towards evidence based research［J］．BMJ，2016，355：i5440．DOI：10.1136/bmj.i5440.
［17］CHA Y J，KIM H.Effect of computer-based cognitive rehabilitation （CBCR） for people with stroke：a systematic review and meta-analysis［J］．NeuroRehabilitation，2013，32（2）：359-368．DOI：10.3233/NRE-130856.
［18］LIU F，LI Z M，JIANG Y J，et al．A meta-analysis of acupuncture use in the treatment of cognitive impairment after stroke［J］．J Altern Complement Med，2014，20（7）：535-544．DOI：10.1089/acm.2013.0364.
［19］ELSNER B，KUGLER J，POHL M，et al．Transcranial direct current stimulation （tDCS） for improving activities of daily living，and physical and cognitive functioning，in people after stroke［J］．Cochrane Database Syst Rev，2016，3：CD009645．DOI：10.1002/14651858.CD009645.pub3.
［20］ZHENG G H，ZHOU W J，XIA R，et al．Aerobic exercises for cognition rehabilitation following stroke：a systematic review［J］．J Stroke Cerebrovasc Dis，2016，25（11）：2780-2789．DOI：10.1016/j.jstrokecerebrovasdis.2016.07.035.
［21］RENTON T，TIBBLES A，TOPOLOVEC-VRANIC J.Neurofeedback as a form of cognitive rehabilitation therapy following stroke：a systematic review［J］．PLoS One，2017，12（5）：e0177290．DOI：10.1371/journal.pone.0177290.
［22］LOETSCHER T，POTTER K J，WONG D，et al．Cognitive rehabilitation for attention deficits following stroke［J］．Cochrane Database Syst Rev，2019，2019（11）．DOI：10.1002/14651858.CD002842.pub3.
［23］REVET M，IMMERZEEL J，VOOGT L，et al．Patients with neuropsychological disorders short after stroke have worse functional outcome：a systematic review and meta-analysis［J］．Disabil Rehabil，2019．[Epub ahead of print]. DOI：10.1080/09638288.2019.1693642.
［24］PANTONI L.Cerebral small vessel disease：from pathogenesis and clinical characteristics to therapeutic challenges［J］．Lancet Neurol，2010，9（7）：689-701．DOI：10.1016/S1474-4422（10）70104-6.
［25］TANG W K，CHEN Y K，LU J Y，et al．White matter hyperintensities in post-stroke depression：a case control study［J］．J Neurol Neurosurg Psychiatry，2010，81（12）：1312-1315．DOI：10.1136/jnnp.2009.203141.
［26］ROSARIO B L，ROSSO A L，AIZENSTEIN H J，et al．Cerebral white matter and slow gait：contribution of hyperintensities and normal-appearing parenchyma［J］．J Gerontol A Biol Sci Med Sci，2016，71（7）：968-973．DOI：10.1093/gerona/glv224.
［27］ROST N S，COUGO P，LORENZANO S，et al．Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke［J］．J Cereb Blood Flow Metab，2018，38（1）：75-86．DOI：10.1177/0271678X17706449.
［28］SAGNIER S，CATHELINE G，DILHARREGUY B，et al．Normal-appearing white matter integrity is a predictor of outcome after ischemic stroke［J］．Stroke，2020，51（2）：449-456．DOI：10.1161/STROKEAHA.119.026886.
［29］SUGAWARA T，CHAN P H.Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia［J］．Antioxid Redox Signal，2003，5（5）：597-607．DOI：10.1089/152308603770310266.
［30］SCHIMIDT H L，VIEIRA A，ALTERMANN C，et al．Memory deficits and oxidative stress in cerebral ischemia-reperfusion：neuroprotective role of physical exercise and green tea supplementation［J］．Neurobiol Learn Mem，2014，114：242-250．DOI：10.1016/j.nlm.2014.07.005.
［31］WANG A，LIU J，MENG X，et al．Association between oxidized low-density lipoprotein and cognitive impairment in patients with ischemic stroke［J］．Eur J Neurol，2018，25（1）：185-191．DOI：10.1111/ene.13497.
［32］JITTIWAT J，WATTANATHORN J.Ginger pharmacopuncture improves cognitive impairment and oxidative stress following cerebral ischemia［J］．J Acupunct Meridian Stud，2012，5（6）：295-300．DOI：10.1016/j.jams.2012.09.003.
［33］LIU Z H，LIU Y T，TU X J，et al．High serum levels of malondialdehyde and 8-OHdG are both associated with early cognitive impairment in patients with acute ischaemic stroke［J］．Sci Rep，2017，7（1）：9493．DOI：10.1038/s41598-017-09988-3.
［34］ALTERMANN C D C，SOUZA M A，SCHIMIDT H L，et al．Short-term green tea supplementation prevents recognition memory deficits and ameliorates hippocampal oxidative stress induced by different stroke models in rats［J］．Brain Res Bull，2017，131：78-84．DOI：10.1016/j.brainresbull.2017.03.007.
［35］YANG J W，WANG X R，MA S M，et al．Acupuncture attenuates cognitive impairment，oxidative stress and NF-κB activation in cerebral multi-infarct rats［J］．Acupunct Med，2019，37（5）：283-291．DOI：10.1136/acupmed-2017-011491.
［36］SU X，WU Z，MAI F，et al．'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion［J］．Int J Mol Med，2019，43（1）：221-232．DOI：10.3892/ijmm.2018.3981.

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