关键词: 糖尿病, 肺肿瘤, 无病生存

Abstract: Background　Lung cancer and diabetes mellitus（DM） are common diseases with age-related increases in incidence.Moreover，clinical coexistence of the two is becoming more common.DM may have an impact on the occurrence and development of lung cancer.Objective　To investigate the effect of DM on the progression-free survival（PFS） in patients with lung cancer.Methods　The clinical information of 189 inpatients with lung cancer with DM（DM group） and 198 inpatients with lung cancer without DM（control group），who were recruited from Department of Respiratory Medicine and Thoracic Surgery，Changhai Hospital，the Second Military Medical University between December 1，2006 and December 31，2016 was collected.Inter-subgroup comparisons were performed in those aged < 65 years and in those aged ≥65 years.The survival curves of patients with different characteristics were drawn and analyzed.And the influencing factors of PFS were analyzed by Cox regression model.Results　Compared with those without DM，lung cancer patients with DM showed much higher proportions of males and older people，higher prevalence of smoking history and commodities （P<0.05）．Moreover，they demonstrated significantly longer mean PFS〔11.0 months，95%CI（8.7，13.3）vs 9.0 months，95%CI（7.8，10.1）〕 （χ2=4.197，P=0.040）.In lung cancer patients aged <65 years，those with DM were found with significantly higher proportions of males，prevalence of smoking history and commodities compared with those without （P<0.05）．Furthermore，they presented longer mean PFS〔11.0 months，95%CI（8.5，13.5） vs 7.0 months，95%CI（6.9，9.1）〕 （χ2=7.257，P=0.007）.In lung cancer patients aged ≥65 years，the mean PFS in those with DM was equal to or greater than that of those without〔11.0 months，95%CI（6.5，15.5） vs 12.0 months，95%CI（6.0，18.0）〕（χ2=0.058，P=0.809）.Cox regression model analysis showed that age，lung cancer staging and treatment regimen were the influencing factors of PFS in lung cancer patients （P<0.05）；lung cancer staging and DM were the influencing factors of PFS in lung cancer patients aged <65 years （P<0.05）；lung cancer staging and treatment regimen were the influencing factors of PFS in lung cancer patients ≥65 years （P<0.05）．Conclusion　For lung cancer patients，especially those aged <65 years，the prevalence of DM was associated with prolonged PFS.

Key words: Diabetes mellitus, Lung neoplasms, Disease-free survival