Page 40 - 中国全科医学2022-29
P. 40

http://www.chinagp.net   E-mail:zgqkyx@chinagp.net.cn  ·3621·


                                                                                                 ·论著·


           孕中晚期增重速率对妊娠期糖尿病孕妇妊娠期并发症

           和分娩结局的影响研究

                                                                                               扫描二维码
               1
                                          1
                                                            1
                         2
                                3
           华雯 ,张丽君 ,卢莎 ,徐佳惠 ,Nisile Kakongoma ,胡文胜                   1,3*                       查看原文
               【摘要】 背景 妊娠期总增重与分娩孕周紧密相连,选择增重速率作为研究指标,可以减少孕周对研究结果的
           干扰。目前有关妊娠期增重速率的既定建议存在争议且很少有研究探讨孕中晚期增重速率与妊娠期糖尿病(GDM)孕
           妇母婴结局的相关性。目的 探讨孕中晚期增重速率对 GDM 孕妇妊娠期并发症及分娩结局的影响。方法 选取 2018
           年 3—12 月在杭州市妇产科医院住院生产并纳入“杭州市母婴健康队列”(注册号:ChiCTR1900026149)的 370 例
           GDM 孕妇为研究对象。根据 2021 年中国营养学会发布的《中国妇女妊娠期体重监测与评价》推荐的孕中晚期增重速率,
           将研究对象分为增重速率过慢组(n=115)、增重速率正常组(n=152)和增重速率过快组(n=103)。分析三组孕妇
           妊娠期并发症发生情况及分娩结局。结果 Logistic 回归分析结果显示,孕中晚期增重速率过快是 GDM 孕妇发生妊娠
           期高血压疾病〔OR=2.661,95%CI(1.291,9.460)〕、妊娠期甲状腺功能减退症〔OR=2.288,95%CI(1.090,4.805)〕、
           高脂血症〔OR=2.085,95%CI(1.656,6.630)〕及分娩巨大儿〔OR=4.591,95%CI(1.238,17.031)〕的危险因素(P<0.05),
           孕中晚期增重速率过快是分娩早产儿〔OR=0.117,95%CI(0.014,0.959)〕的保护因素(P<0.05)。结论 孕妇妊娠
           期增重不合理现象普遍,孕中晚期增重速率过快增加了 GDM 孕妇发生妊娠期高血压疾病、妊娠期甲状腺功能减退症、
           高脂血症及分娩巨大儿的风险,但降低了发生早产的风险。
               【关键词】 糖尿病,妊娠;孕中晚期增重速率;妊娠并发症;分娩结局;队列研究
               【中图分类号】 R 714.256 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2022.0410
               华雯,张丽君,卢莎,等 . 孕中晚期增重速率对妊娠期糖尿病孕妇妊娠期并发症和分娩结局的影响研究[J]. 中
           国全科医学,2022,25(29):3621-3626. [www.chinagp.net]
               HUA W,ZHANG L J,LU S,et al. Association of weight gain rate in second and third trimesters with pregnancy
           complications and delivery outcomes in women with gestational diabetes mellitus[J]. Chinese General Practice,2022,25(29):
           3621-3626.

           Association of Weight Gain Rate in Second and Third Trimesters with Pregnancy Complications and Delivery Outcomes
                                                      1
                                                                  2
                                                                                                  1
                                                                                   1
                                                                          3
           in Women with Gestational Diabetes Mellitus HUA Wen ,ZHANG Lijun ,LU Sha ,XU Jiahui ,Nisile Kakongoma ,HU
           Wensheng 1,3*
           1.The Fourth Clinical School of Zhejiang Chinese Medicine University,Hangzhou 310053,China
           2.School of Public Health,Hangzhou Normal University Division of Health Sciences,Hangzhou 311121,China
           3.Hangzhou Women's Hospital,Hangzhou 310008,China
           *
           Corresponding author:HU Wensheng,Chief physician,Professor;E-mail:huws@zju.edu.cn
               【Abstract】 Background The total gestational weight gain is closely related to the gestational week at delivery.
           Choosing the gestational weight gain rate(GWGR) as a indicator can reduce the interference of gestational week on the results.
           Currently,available recommendations regarding GWGR are controversial. Few studies have explored the correlation between
           GWGR in second and third trimesters and delivery outcomes in women with gestational diabetes mellitus(GDM). Objective
            To investigate the association of GWGR in second and third trimesters with pregnancy complications and delivery outcomes
           in women with GDM. Methods A total of 370 women with GDM were selected,who had an experience of undergoing delivery
           in Hangzhou Women's Hospital from March to December 2018,and were included in the Hangzhou Maternal and Offspring
           Health Cohort Study (clinical trial registration number:ChiCTR1900026149). According to GWGR in second and third

               基金项目:国家自然科学基金面上项目(82173530);国家卫生健康委科学研究基金—浙江省医药卫生重大科技计划项目
           (WKJ-ZJ-1911);杭州市卫生科技计划重点项目(ZD20200035)
               1.310053浙江省杭州市,浙江中医药大学第四临床医学院 2.311121浙江省杭州市,杭州师范大学医学部公共卫生学院 3.310008
           浙江省杭州市妇产科医院
               *
               通信作者:胡文胜,主任医师,教授;E-mail:huws@zju.edu.cn
               本文数字出版日期:2022-07-21
   35   36   37   38   39   40   41   42   43   44   45