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10.1152/ajplung.00457.2019. 10.1186/s12931-020-1322-5.
［2］XIA M L，XU H，DAI W，et al. The role of HDAC2 in cigarette ［16］HIRAI K，SHIRAI T，RACHI Y，et al. Impact of gene expression
smoke-induced airway inflammation in a murine model of asthma and associated with glucocorticoid-induced transcript 1 （GLCCI1）
the effect of intervention with roxithromycin［J］. J Asthma，2018， on severe asthma and future exacerbation［J］. Biol Pharm Bull，
55（4）：337-344. DOI：10.1080/02770903.2017.1337788. 2019，42（10）：1746-1752. DOI：10.1248/bpb.b19-00476.
［3］ZHOU J，GENG F H，XU J M，et al. PM2.5 exposure and cold ［17］LAI T W，WU M D，ZHANG C，et al. HDAC2 attenuates airway
stress exacerbates asthma in mice by increasing histone acetylation inflammation by suppressing IL-17A production in HDM-challenged
+
in IL-4 gene promoter in CD 4 T cells［J］. Toxicol Lett，2019， mice［J］. Am J Physiol Lung Cell Mol Physiol，2019，316（1）：
316：147-153. DOI：10.1016/j.toxlet.2019.09.011. L269-279. DOI：10.1152/ajplung.00143.2018.
［4］MA L Y，BIAN X，LIN W C. The dual HDAC-PI3K inhibitor ［18］SAKURAI H，MORISHIMA Y，ISHII Y，et al. Sulforaphane
CUDC-907 displays single-agent activity and synergizes with PARP ameliorates steroid insensitivity through an Nrf2-dependent
inhibitor olaparib in small cell lung cancer［J］. J Exp Clin Cancer pathway in cigarette smoke-exposed asthmatic mice［J］. Free
Res，2020，39（1）：219. DOI：10.1186/s13046-020-01728-2. Radic Biol Med，2018，129：473-485. DOI：10.1016/j.
［5］CHENG Q，SHANG Y X，HUANG W J，et al. p300 mediates the freeradbiomed.2018.10.400.
histone acetylation of ORMDL3 to affect airway inflammation and ［19］BARNES P J. Corticosteroid resistance in patients with asthma
remodeling in asthma［J］. Int Immunopharmacol，2019，76： and chronic obstructive pulmonary disease［J］. J Allergy Clin
105885. DOI：10.1016/j.intimp.2019.105885. Immunol，2013，131（3）：636-645. DOI：10.1016/j.
［6］TANG L L，CHEN Q G，MENG Z Y，et al. Suppression of sirtuin-1 jaci.2012.12.1564.
increases IL-6 expression by activation of the Akt pathway during ［20］FERRARO M，GJOMARKAJ M，SIENA L，et al. Formoterol and
allergic asthma［J］. Cell Physiol Biochem，2017，43（5）： fluticasone propionate combination improves histone deacetylation
1950-1960. DOI：10.1159/000484119. and anti-inflammatory activities in bronchial epithelial cells
［7］STYLIANOU E. Epigenetics of chronic inflammatory diseases［J］. exposed to cigarette smoke［J］. Biochim Biophys Acta Mol
J Inflamm Res，2019，12：1-14. DOI：10.2147/JIR.S129027. Basis Dis，2017，1863（7）：1718-1727. DOI：10.1016/j.
［8］HE J，QIN M，CHEN Y Y，et al. Epigenetic regulation of matrix bbadis.2017.05.003.
metalloproteinases in inflammatory diseases：a narrative review［J］. ［21］ZHANG H P，WANG L，FU J J，et al. Association between histone
Cell Biosci，2020，10：86. DOI：10.1186/s13578-020-00451-x. hyperacetylation status in memory T lymphocytes and allergen-
［9］KOOPMANS T，EILERS R，MENZEN M，et al. Β-catenin directs induced eosinophilic airway inflammation［J］. Respirology，
nuclear factor-κB p65 output via CREB-binding protein/p300 in 2016，21（5）：850-857. DOI：10.1111/resp.12774.
human airway smooth muscle［J］. Front Immunol，2017，8： ［22］PAN Y L，LIU L，LI S J，et al. Activation of AMPK inhibits
1086. DOI：10.3389/fimmu.2017.01086. TGF-β1-induced airway smooth muscle cells proliferation and
［10］HUANG Z W，LIEN G S，LIN C H，et al. p300 and C/EBPβ- its potential mechanisms［J］. Sci Rep，2018，8（1）：3624.
regulated IKKβ expression are involved in thrombin-induced IL- DOI：10.1038/s41598-018-21812-0.
8/CXCL8 expression in human lung epithelial cells［J］. Pharmacol ［23］LU Y，LI Z J，XIE B Q，et al. Hsa-miR-20a-5p attenuates
Res，2017，121：33-41. DOI：10.1016/j.phrs.2017.04.020. allergic inflammation in HMC-1 cells by targeting HDAC4［J］.
［11］CUI Z L，GU W，DING T，et al. Histone modifications of Notch1 Mol Immunol，2019，107：84-90. DOI：10.1016/j.
+
promoter affect lung CD 4 T cell differentiation in asthmatic rats［J］. molimm.2019.01.010.
Int J Immunopathol Pharmacol，2013，26（2）：371-381. DOI： ［24］HOU X X，WAN H Y，AI X Y，et al. Histone deacetylase inhibitor
10.1177/039463201302600210. regulates the balance of Th17/Treg in allergic asthma［J］. Clin
［12］XIAO X，FAN Y H，LI J H，et al. Guidance of super-enhancers Respir J，2016，10（3）：371-379. DOI：10.1111/crj.12227.
in regulation of IL-9 induction and airway inflammation［J］. J Exp ［25］MA K，LU N，ZOU F，et al. Sirtuins as novel targets in the
Med，2018，215（2）：559-574. DOI：10.1084/jem.20170928. pathogenesis of airway inflammation in bronchial asthma［J］.
［13］MALLESKE D T，HAYES D Jr，LALLIER S W，et al. Regulation Eur J Pharmacol，2019，865：172670. DOI：10.1016/j.
of human airway epithelial tissue stem cell differentiation by ejphar.2019.172670.
β-catenin，P300，and CBP［J］. Stem Cells，2018，36（12）： ［26］LEE Y G，READER B F，HERMAN D，et al. Sirtuin 2 enhances
1905-1916. DOI：10.1002/stem.2906. allergic asthmatic inflammation［J］. JCI Insight，2019，4（4）：
［14］SU X M，REN Y，LI M L，et al. Performance evaluation of 124710. DOI：10.1172/jci.insight.124710.
histone deacetylases in lungs of mice exposed to ovalbumin ［27］FANG P，XUE Y，ZHANG Y H，et al. SIRT7 regulates the TGF-
aerosols［J］. J Physiol Pharmacol，2018，69（2）. DOI： β1-induced proliferation and migration of mouse airway smooth
10.26402/jpp.2018.2.12. muscle cells by modulating the expression of TGF-β receptor
［15］LI M L，SU X M，REN Y，et al. HDAC8 inhibitor attenuates I［J］. Biomedecine Pharmacother，2018，104：781-787. DOI：
airway responses to antigen stimulus through synchronously 10.1016/j.biopha.2018.05.060.
suppressing galectin-3 expression and reducing macrophage-2 ［28］JANG H Y，GU S N，LEE S M，et al. Overexpression of sirtuin
polarization［J］. Respir Res，2020，21（1）：62. DOI： 6 suppresses allergic airway inflammation through deacetylation of