Progress in Clinical Diagnosis and Treatment of Wake-up Stroke

doi:10.12114/j.issn.1007-9572.2022.0349

Abstract

Abstract:

Wake-up stroke (WUS) refers to acute cerebrovascular disease without new onset stroke symptoms at bedtime whereas new onset neurological deficits after waking up or during sleep. With unknown onset time of symptoms, most cases are ischemic stroke. Recently, with the exploration of the pathogenesis of WUS and the application and development of imaging techniques such as electron computed tomography and magnetic resonance imaging, it is possible to explore the ischemic penumbra and cerebral perfusion, judge the presence of salvageable brain tissue, and develop a suitable treatment plan, which has become a hot spot in clinical research. This review focuses on the clinical diagnosis and treatment of stroke after waking up.

Key words: Wake-up stroke, Ischemic stroke, Blood pressure, Sleep apnea syndromes, Hrombolytic therapy, Mechanical thrombectomy

摘要：

醒后卒中（WUS）是指睡前无新发卒中症状，在醒后或睡眠过程中出现新发神经系统功能缺损的急性脑血管病，症状开始时间未知，多属缺血性卒中。近年来，随着对WUS发病机制的探究以及电子计算机断层扫描和磁共振成像等影像学技术的应用和发展，临床可以对缺血半暗带及脑灌注进行探索，判断是否存在可挽救的脑组织，制定合适的治疗方案，已成为临床研究热点。本文就WUS的临床诊断及治疗等方面进行综述。

关键词: 醒后卒中, 缺血性卒中, 血压, 睡眠呼吸暂停综合征, 静脉溶栓, 机械取栓

Xiaoyi LIU,Baoai WANG. Progress in Clinical Diagnosis and Treatment of Wake-up Stroke[J]. Chinese General Practice, 2022, 25(29): 3607-3615. DOI: 10.12114/j.issn.1007-9572.2022.0349.
刘筱翼,王保爱. 醒后卒中临床诊治的研究新进展[J]. 中国全科医学, 2022, 25(29): 3607-3615. DOI: 10.12114/j.issn.1007-9572.2022.0349.

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