Abstract: Background　Chronic obstructive pulmonary disease（COPD）is closely related to cardiovascular disease， but the mechanism of their interaction is still unclear. Hypertension is the most common comorbidity of COPD，and it is also an independent risk factor for cardiovascular diseases. Current studies believe that blood pressure variability is also a risk factor for cardiovascular disease，and blood pressure variability can better reflect the patient's blood pressure fluctuation than a single blood pressure value，so is blood pressure variability a bridge between COPD and cardiovascular disease At present，there are no relevant studies in China. Objective　To investigate the correlation study of pulmonary function and blood pressure variability in patients with COPD and hypertension. Methods　341 COPD patients with hypertension who visited the respiratory and critical care medicine outpatient department of kailuan general hospital from september 2020 to september 2023. On the day of the patient's visit，data were collected on the patient's lung function indicators，height，weight，age，sex，use of antihypertensive medications，and lifestyle habits（whether they smoke or drink alcohol）. Multiple factor linear regression was used to analyze the correlation between lung function indicators（percentage of forced vital capacity to predicted value：FVC%pred；percentage of forced expiratory volume to predicted value in the first second：FEV1%pred；the ratio of forced expiratory volume in one second to forced vital capacity：FEV1/FVC）and blood pressure variability（standard deviation of systolic blood pressure：SDSBP，standard deviation of diastolic blood pressure：SDDBP）. Results　（1）Males have higher body mass index，smoking rate，and alcohol consumption rate than females，while females have a higher predicted forced vital capacity percentage（FVC%pred）than males（P<0.05）.（2）FEV1%pred is negatively correlated with blood pressure variability（SDSBP，SDDBP）（rs values were -0.149 and -0.114，respectively，P<0.05）.（3）FEV1%pred is negatively linearly correlated with SDSBP and SDDBP，with B values（95% CI）of -0.566（-1.078--0.054）and -0.427（-0.761--0.093），respectively；FVC%pred and FEV1/FVC were not correlated with SDSBP and SDDBP. Conclusion　FEV1%pred is negatively linearly correlated with SDSBP and SDDBP.

Key words: Pulmonary disease, chronic obstructive；Hypertension；Pulmonary function；Blood pressure variability；Linear regression analysis

摘要： 背景　慢性阻塞性肺疾病（COPD）与心血管疾病关系密切，但是两者之间相互影响的机制仍不明确。高血压作为COPD最常见的合并症，同时也是心血管疾病的独立危险因素。目前研究认为血压变异性也是心血管疾病的危险因素，血压变异性比单次血压值更能体现患者血压波动的情况，那么血压变异性是否为COPD与心血管疾病之间的桥梁？目的　探讨COPD合并高血压患者肺功能与血压变异性的相关性。方法　采用连续抽样法，选取2020年9月—2023年9月于开滦总医院呼吸与危重症医学科门诊就诊的341例COPD合并高血压患者，并在患者就诊当天收集肺功能指标、身高、体重、年龄、性别、是否应用降压药物及生活习惯（是否吸烟、饮酒）等指标。采用多因素线性回归分析肺功能指标［用力肺活量占预计值百分比（FVC%pred），第1秒用力呼气容积占预计值百分比（FEV1%pred），第1秒用力呼气容积与用力肺活量比值（FEV1/FVC）］与血压变异性［收缩压标准差（SDSBP），舒张压标准差（SDDBP）］的相关性。结果　（1）男性BMI、吸烟比例、饮酒比例高于女性，女性FVC%pred高于男性（P<0.05）。（2）FEV1%pred与血压变异性（SDSBP、SDDBP）均呈负相关（rs值分别为-0.149、-0.114，P<0.05）。（3）FEV1%pred与SDSBP、SDDBP均呈负线性相关，B（95%CI）分别为-0.566（-1.078~-0.054）、-0.427（-0.761~-0.093）；FVC%pred和FEV1/FVC与SDSBP、SDDBP均无相关性。结论　FEV1%pred与SDSBP、SDDBP呈负相关。

关键词: 肺疾病, 慢性阻塞性；高血压；肺功能；血压变异性；线性回归分析