Chinese General Practice ›› 2022, Vol. 25 ›› Issue (29): 3616-3620.DOI: 10.12114/j.issn.1007-9572.2022.0344
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Received:
2022-02-14
Revised:
2022-06-10
Published:
2022-10-15
Online:
2022-07-21
Contact:
Wenge XU
About author:
通讯作者:
徐文革
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基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0344
组别 | 例数 | 异烟肼 | 利福平 | 乙胺丁醇 | 链霉素 |
---|---|---|---|---|---|
PTB组 | 216 | 26(12.04) | 21(9.72) | 3(1.39) | 14(6.48) |
DM-PTB组 | 141 | 32(22.70) | 20(14.18) | 3(2.13) | 17(12.06) |
χ2值 | 7.12 | 1.67 | 0.28 | 3.34 | |
P值 | 0.01 | 0.20 | 0.60 | 0.07 |
Table 1 First-line drug-resistant profile between pulmonary tuberculosis patients with and without diabetes
组别 | 例数 | 异烟肼 | 利福平 | 乙胺丁醇 | 链霉素 |
---|---|---|---|---|---|
PTB组 | 216 | 26(12.04) | 21(9.72) | 3(1.39) | 14(6.48) |
DM-PTB组 | 141 | 32(22.70) | 20(14.18) | 3(2.13) | 17(12.06) |
χ2值 | 7.12 | 1.67 | 0.28 | 3.34 | |
P值 | 0.01 | 0.20 | 0.60 | 0.07 |
组别 | 例数 | 单耐药 | 多耐药 | 耐多药 | |||
---|---|---|---|---|---|---|---|
异烟肼 | 利福平 | 乙胺丁醇 | 链霉素 | ||||
PTB组 | 216 | 9(4.17) | 6(2.78) | 0 | 0 | 4(1.85) | 14(6.48) |
DM-PTB组 | 141 | 11(7.80) | 1(0.71) | 0 | 2(1.42) | 4(2.84) | 18(12.77) |
χ2值 | 2.13 | 0.98 | — | — | 0.06 | 4.13 | |
P值 | 0.14 | 0.32 | — | 0.16 | 0.80 | 0.04 |
Table 2 Different types of drug resistance between pulmonary tuberculosis patients with and without diabetes
组别 | 例数 | 单耐药 | 多耐药 | 耐多药 | |||
---|---|---|---|---|---|---|---|
异烟肼 | 利福平 | 乙胺丁醇 | 链霉素 | ||||
PTB组 | 216 | 9(4.17) | 6(2.78) | 0 | 0 | 4(1.85) | 14(6.48) |
DM-PTB组 | 141 | 11(7.80) | 1(0.71) | 0 | 2(1.42) | 4(2.84) | 18(12.77) |
χ2值 | 2.13 | 0.98 | — | — | 0.06 | 4.13 | |
P值 | 0.14 | 0.32 | — | 0.16 | 0.80 | 0.04 |
组别 | 例数 | 异烟肼 | 利福平 | 乙胺丁醇embB基因306位氨基酸 | 链霉素 | |||||
---|---|---|---|---|---|---|---|---|---|---|
inhA基因-15位碱基 | KatG基因315位氨基酸 | rpoB基因RRDR区 | rpoB基因516位氨基酸 | rpoB基因526位氨基酸 | rpoB基因531位氨基酸 | rpsL基因43位氨基酸 | rpsL基因88位氨基酸 | |||
PTB组 | 62 | 0 | 5(8.06) | 6(9.68) | 0 | 4(6.45) | 5(8.06) | 0 | 2(3.23) | 1(1.61) |
DM-PTB组 | 61 | 0 | 7(11.48) | 3(4.92) | 0 | 0 | 2(3.28) | 1(1.64) | 0 | 0 |
χ2值 | — | 0.41 | 0.45 | — | — | 0.57 | — | — | — | |
P值 | — | 0.52 | 0.51 | — | 0.12 | 0.25 | 0.50 | 0.50 | 1.00 |
Table 3 Rate of mutation at the gene loci between pulmonary tuberculosis patients with and without diabetes
组别 | 例数 | 异烟肼 | 利福平 | 乙胺丁醇embB基因306位氨基酸 | 链霉素 | |||||
---|---|---|---|---|---|---|---|---|---|---|
inhA基因-15位碱基 | KatG基因315位氨基酸 | rpoB基因RRDR区 | rpoB基因516位氨基酸 | rpoB基因526位氨基酸 | rpoB基因531位氨基酸 | rpsL基因43位氨基酸 | rpsL基因88位氨基酸 | |||
PTB组 | 62 | 0 | 5(8.06) | 6(9.68) | 0 | 4(6.45) | 5(8.06) | 0 | 2(3.23) | 1(1.61) |
DM-PTB组 | 61 | 0 | 7(11.48) | 3(4.92) | 0 | 0 | 2(3.28) | 1(1.64) | 0 | 0 |
χ2值 | — | 0.41 | 0.45 | — | — | 0.57 | — | — | — | |
P值 | — | 0.52 | 0.51 | — | 0.12 | 0.25 | 0.50 | 0.50 | 1.00 |
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