Glymphatic System: a New Research Direction for the Pathogenesis of Brain Diseases

doi:10.12114/j.issn.1007-9572.2022.0326

Chinese General Practice ›› 2022, Vol. 25 ›› Issue (29): 3603-3606.DOI: 10.12114/j.issn.1007-9572.2022.0326

Special Issue: 脑健康最新研究合辑

• Hot Topics: Brain Health • Previous Articles Next Articles

Glymphatic System: a New Research Direction for the Pathogenesis of Brain Diseases

1. School of Medical and Life Sciences, Chengdu University of TCM, Chengdu 611137, China
2. School of Health Preservation and Rehabilitation, Chengdu University of TCM, Chengdu 610075, China
3. Department of Neurology, Hospital of Chengdu University of TCM, Chengdu 610072, China

Received:2022-03-06 Revised:2022-05-25 Published:2022-10-15 Online:2022-06-02
Contact: Shuoguo JIN
About author:
CHEN Z R, YI T, GAO P, et al. Glymphatic system: a new research direction for the pathogenesis of brain diseases[J]. Chinese General Practice, 2022, 25 (29) : 3603-3606, 3615.

胶质淋巴系统——脑部疾病机制研究新方向

1．611137　四川省成都市，成都中医药大学医学与生命科学学院
2．610075　四川省成都市，成都中医药大学养生康复学院
3．610072　四川省成都市，成都中医药大学附属医院神经内科

通讯作者: 金硕果
作者简介:
陈泽然，易婷，高萍，等.胶质淋巴系统——脑部疾病机制研究新方向[J].中国全科医学，2022，25（29）：3603-3606，3615. [www.chinagp.net] 作者贡献：陈泽然提出研究思路、资料收集与整理、论文撰写；易婷、高萍负责资料收集；陈泽然、金硕果负责最终版本修订，对论文负责。所有作者确认论文终稿。
基金资助:
国家自然科学基金青年科学基金项目(82004342); 成都中医药大学2021年杏林学者学科人才科研提升计划项目(QJRC2021006); 成都中医药大学附属医院"百人计划"科研项目(21-Q24)

Abstract

Abstract:

The glymphatic system is mainly mediated by aquaporin 4 on astrocytes and relies on the exchange and flow of cerebrospinal fluid and brain tissue fluid in the vascular space around arteries and veins. It is a common feature of encephalopathy such as Alzheimer's disease, stroke, Parkinson's disease, insomnia, depression. It is a new brain metabolic pathway that can remove metabolites including β-amyloid and lactate. This paper comprehensively analyzes the global research on the glial lymphatic system in brain diseases, and concludes that the glial lymphatic system may bring a new perspective for the study of the pathogenesis and diagnosis and treatment strategies of neurodegenerative diseases; glial lymphatic system is expected to provide new and effective evidence for the diagnosis of some brain diseases; the glial lymphatic system may be a new way to treat brain diseases.

Key words: Glymphatic system, Brain diseases, Brain perivascular spaces, Aquaporin 4

摘要：

胶质淋巴系统是一个主要由星形胶质细胞水通道蛋白4介导的依靠动脉、静脉周围血管间隙的脑脊液-脑组织液交换流动的系统，是阿尔茨海默病、脑卒中、帕金森病、失眠、抑郁症等脑病的共同特征，是一条新的脑代谢途径，可以清除包括β-淀粉样蛋白、乳酸在内的代谢产物。本文综合分析了全球有关胶质淋巴系统在脑部疾病的研究，得出：胶质淋巴系统可能为神经退行性疾病等发病机制和诊治策略研究带来新视角；胶质淋巴系统有望为一些脑部疾病诊断提供新的有效证据；胶质淋巴系统可能是脑部疾病治疗给药方式的新途径。

关键词: 神经胶细胞类淋巴系统, 脑疾病, 脑部血管周围间隙, 水通道蛋白质4

Zeran CHEN,Ting YI,Ping GAO, et al. Glymphatic System: a New Research Direction for the Pathogenesis of Brain Diseases[J]. Chinese General Practice, 2022, 25(29): 3603-3606. DOI: 10.12114/j.issn.1007-9572.2022.0326.
陈泽然,易婷,高萍等. 胶质淋巴系统——脑部疾病机制研究新方向[J]. 中国全科医学, 2022, 25(29): 3603-3606. DOI: 10.12114/j.issn.1007-9572.2022.0326.

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Glymphatic System: a New Research Direction for the Pathogenesis of Brain Diseases

胶质淋巴系统——脑部疾病机制研究新方向

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