Visualization Analysis of Global Advances and Hot Spots in Intermittent Fasting

doi:10.12114/j.issn.1007-9572.2022.0811

Abstract

Abstract:

Background

Intermittent fasting refers to the eating pattern in which the individual abstains from eating food for a certain period during a day or week. As research deepens, intermittent fasting has been shown to play an important role in the prevention and treatment of chronic diseases.

Objective

We aimed to provide a visualization analysis of the research hot spots and trends in international intermittent fasting studies over the past decade, in order to provide references and basis for future relevant research.

Methods

Existing studies on intermittent fasting published from January 2010 to April 2022 were retrieved from the Web of Science Core Collection on April 26, 2022. CiteSpace was used to examine the distribution of disciplines, authors and institutions cooperation, high-frequency keywords, and keywords with citation bursts of the included literature, and finally relevant maps were created.

Results

A total of 2 786 articles were ultimately included. The number of these publications showed an increasing trend year by year from 2010 to 2022, although the global research level remained uneven. The country with the highest number of publications was the United States (n=650), the institution with the highest number of publications was the University of Illinois (n=49), and the author with the most publications was Professor Krista A Varady of the University of Illinois (n=26). The high-frequency keywords included weight loss, intermittent fasting, obesity, insulin resistance, metabolism, caloric restriction, gene expression, circadian rhythms, and diet. The research themes were renamed as food intake restriction, circadian rhythms, weight control, metabolic-related diseases and other diseases, and related mechanisms after the cluster analysis. Burst keywords included time-restricted feeding, suprachiasmatic nucleus, mice, growth, and mortality.

Conclusion

The research hot spots of intermittent fasting are mainly focused on its relationship with biological rhythms/circadian rhythms, its effect on improving chronic diseases and other diseases, and sensitive genes and related mechanisms. Future research should focus on intermittent fasting in different populations such as children/adolescents, pregnant women, the elderly, and professional athletes/fitness enthusiasts, and clinically evaluate and compare the intervention effects and safety of different intermittent fasting patterns, ultimately forming a personalized intermittent fasting intervention model and exploring its biological mechanism.

Key words: Intermittent fasting, Time restricted, Energy restriction, Dietary pattern, CiteSpace

摘要：

背景

间歇性禁食指设定进食时间，并在进食时间之外保持禁食的饮食方式。随着研究的深入，该饮食方式已被证明在慢性病防治中可发挥重要作用。

目的

对国际上间歇性禁食近10余年的研究热点和趋势进行可视化分析，为该领域未来研究提供参考和依据。

方法

2022-04-26，检索Web of Science核心数据库中间歇性禁食主题相关研究，检索时限设定为2010年1月至2022年4月。通过CiteSpace软件对纳入文献的学科分布、作者及机构合作关系、高频关键词、突现性被引关键词等进行分析，并绘制相关图谱。

结果

最终检索纳入2 786篇文献。2010—2022年间歇性禁食相关论文的发文量呈现逐年上升的趋势，但全球研究水平仍然不均衡。发文量最高的国家为美国（650篇），发文量最高的机构为伊利诺伊大学（49篇），发文量最高的作者为伊利诺伊大学的Krista A Varady（26篇）。研究高频关键词主要包括减重、间歇性禁食、肥胖、胰岛素抵抗、代谢、热量限制、基因表达、生物节律和饮食等；研究主题聚类后重新命名得到食物摄入限制、生物节律、体质量控制、代谢相关疾病和其他疾病、相关机制研究；突现关键词包括时间限制性禁食、视交叉上核、老鼠、增长、死亡率等。

结论

间歇性禁食国际研究热点集中于：与生物节律/昼夜节律的关系、改善慢性病和其他疾病的效果、敏感基因和相关机制。未来的研究应着眼于不同人群，如儿童/青少年、孕期女性、老年人和专业运动员/运动健身人群，并探索临床应用中不同模式下的间歇性禁食干预效果和安全性，最终形成个性化的间歇性禁食干预模式，并探讨其生物学机制。

关键词: 间歇性禁食疗法, 时间限制, 能量限制, 饮食模式, CiteSpace

GUO Xian,ZHOU Yanbing,LIU Jingying, et al. Visualization Analysis of Global Advances and Hot Spots in Intermittent Fasting[J]. Chinese General Practice, 2023, 26(16): 2036-2046. DOI: 10.12114/j.issn.1007-9572.2022.0811.
郭娴,周雁冰,刘晶莹等. 间歇性禁食国际研究进展与热点的可视化分析[J]. 中国全科医学, 2023, 26(16): 2036-2046. DOI: 10.12114/j.issn.1007-9572.2022.0811.

Figures/Tables 17

References 67

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序号	研究领域	发文量（篇）	中心度
1	Nutrition & Dietetics（营养学）	337	0.14
2	Sport sciences（运动科学）	226	0.31
3	Agriculture（农业学）	207	0.07
4	Endocrinology & Metabolism（内分泌和代谢）	197	0.02
5	Agriculture，dairy & Animal science（农业、乳制品和动物科学）	191	0.02
6	Neurosciences & Neurology（神经科学）	154	0.04
7	Physiology（生理学）	137	0.07
8	Science & Technology-Other topics（科技其他主题）	137	0.12
9	Multidisciplinary sciences（多学科）	134	0.01
10	Environmental sciences & Ecology（环境科学与生态学）	105	0.06

序号	研究领域	发文量（篇）	中心度
1	Nutrition & Dietetics（营养学）	337	0.14
2	Sport sciences（运动科学）	226	0.31
3	Agriculture（农业学）	207	0.07
4	Endocrinology & Metabolism（内分泌和代谢）	197	0.02
5	Agriculture，dairy & Animal science（农业、乳制品和动物科学）	191	0.02
6	Neurosciences & Neurology（神经科学）	154	0.04
7	Physiology（生理学）	137	0.07
8	Science & Technology-Other topics（科技其他主题）	137	0.12
9	Multidisciplinary sciences（多学科）	134	0.01
10	Environmental sciences & Ecology（环境科学与生态学）	105	0.06

序号	期刊名称	影响因子（2020年）	文献篇数（篇）	中心度
1	PLoS One	3.24	811	0.03
2	Proceedings of the National Academy of Sciences of the United States of America	11.205	711	0.01
3	Science	47.728	574	0.02
4	Cell Matablism	27.287	548	0.09
5	Nature	49.962	526	0.05
6	American Journal of Clinical Nutrition	7.045	517	0.04
7	International Journal of Pediatric Obesity	5.095	444	0.04
8	Obesity	5.002	424	0.04
9	Physiology & Behavior	3.244	400	0.02
10	Cell	41.582	373	0.04

序号	期刊名称	影响因子（2020年）	文献篇数（篇）	中心度
1	PLoS One	3.24	811	0.03
2	Proceedings of the National Academy of Sciences of the United States of America	11.205	711	0.01
3	Science	47.728	574	0.02
4	Cell Matablism	27.287	548	0.09
5	Nature	49.962	526	0.05
6	American Journal of Clinical Nutrition	7.045	517	0.04
7	International Journal of Pediatric Obesity	5.095	444	0.04
8	Obesity	5.002	424	0.04
9	Physiology & Behavior	3.244	400	0.02
10	Cell	41.582	373	0.04

序号	研究机构	地区	发文量（篇）
1	University of Illinois（伊利诺伊大学）	美国	49
2	University of Sydney（悉尼大学）	澳大利亚	27
3	Johns Hopkins University（约翰斯·霍普金斯大学）	美国	25
4	NIA（美国国立卫生研究院）	美国	24
5	University of Sao Paulo（圣保罗大学）	巴西	22
6	University of Copenhagen（哥本哈根大学）	丹麦	21
7	University of Minnesota（明尼苏达大学）	美国	21
8	University of Adelaide（阿德莱德大学）	澳大利亚	20
9	University of Alabama Birmingham（阿拉巴马大学伯明翰分校）	美国	19
10	University of Florida（佛罗里达州立大学）	美国	19