Abstract: Background　Constipation has become a common problem among Chinese people along with the quickened pace of life. Although constipation is not fatal，it may increase the mortality rate of cardiovascular and cerebrovascular diseases. There is a lack of comprehensive data from large-scale surveys about chronic constipation prevalence in Chinese adults. Objective　To systematically evaluate chronic constipation prevalence in Chinese adults，so as to provide a basis for epidemiological studies of chronic constipation. Methods　Cross-sectional studies on chronic constipation in Chinese adults were searched in databases of CNKI，VIP，WanFang Data，CBM，PubMed，EMbase，The Cochrane Library，and Web of Science from inception to December 31，2019. Two reviewers enrolled studies in accordance with the inclusion and exclusion criteria，extracted data，and evaluated methodological quality using the ARHQ methodology checklist（11 items） for cross-sectional studies. Stata 15.0 was used for meta-analysis. Results　19 studies，involving 37 242 subjects were included. Meta-analysis showed that the overall chronic constipation prevalence in Chinese adults was 10.9%〔95%CI（8.8%，13.0%）〕. Subgroup analysis showed that the prevalence was 7.0%〔95%CI（4.1%，10.0%）〕 for men and 11.5%〔95%CI（9.3%，13.7%）〕 for women，and 9.3%〔95%CI（3.7%，14.8%）〕 for urban areas and 10.5%〔95%CI（5.8%，15.1%）〕 for rural areas. The prevalence for subgroups of elementary or below，junior/senior high school，and two-/three-year college education or above was 12.2%〔95%CI（7.4%，17.0%）〕，12.3%〔95%CI（8.1%，16.4%）〕，and 13.2%〔95%CI（8.2%，18.1%）〕，respectively. The prevalence was 7.4%〔95%CI（5.6%，9.2%）〕 for southerners and 15.0%〔95%CI（10.6%，19.4%）〕 for northerners. The prevalence for adults surveyed before 2003，between 2004—2008，2009—2013，and 2014—2018 was 5.0%〔95%CI（3.0%，7.0%）〕，6.3%〔95%CI（1.3%，11.3%）〕，11.2%〔95%CI（4.9%，17.5%）〕 and 13.4%〔95%CI（9.1%，17.7%）〕，respectively. Conclusion　The prevalence of chronic constipation among Chinese adults is increasing year by year，with differences by gender，place of residence（rural or urban），level of education and region.

Key words: Chronic constipation, Adults, Prevalence, Meta-analysis, Cross-sectional study, China

摘要： 背景　随着现代生活节奏的加快，便秘已成为我国人群普遍存在的问题。便秘虽不致死，但会增加心脑血管疾病的致死率。而目前尚缺乏大样本的调查数据对中国成年人慢性便秘患病率进行全面报道。目的　系统评价中国成年人慢性便秘的患病率，为慢性便秘的流行病学研究提供基础。方法　计算机检索中国知网、维普网、万方数据知识服务平台、中国生物医学文献数据库、PubMed、EMbase、The Cochrane Library、Web of Science，检索时限均从建库到2019-12-31，收集有关中国成年人慢性便秘的横断面研究。由两位评价员按照纳入与排除标准对所获文献独立进行筛选、提取，并采用美国卫生保健质量和研究机构推荐的11条标准进行文献质量评价，采用Stata 15.0软件对提取数据进行Meta分析。结果　共纳入19个研究，包括37 242例调查对象。Meta分析结果显示，中国成年人慢性便秘总患病率为10.9%〔95%CI（8.8%，13.0%）〕。亚组分析显示：男性和女性患病率分别为7.0%〔95%CI（4.1%，10.0%）〕和11.5%〔95%CI（9.3%，13.7%）〕；城市地区和农村地区患病率分别为9.3%〔95%CI（3.7%，14.8%）〕和10.5%〔95%CI（5.8%，15.1%）〕；文化程度是小学及以下、初/高中、大专及以上组的患病率分别为12.2%〔95%CI（7.4%，17.0%）〕、12.3%〔95%CI（8.1%，16.4%）〕、13.2%〔95%CI（8.2%，18.1%）〕；南方和北方地区患病率分别为7.4%〔95%CI（5.6%，9.2%）〕和15.0%〔95%CI（10.6%，19.4%）〕；调查时间为2003年以前及2004—2008、2009—2013、2014—2018年组的患病率分别为5.0%〔95%CI（3.0%，7.0%）〕、6.3%〔95%CI（1.3%，11.3%）〕、11.2%〔95%CI（4.9%，17.5%）〕、13.4%〔95%CI（9.1%，17.7%）〕。结论　我国成年人慢性便秘患病率在逐年增高，不同性别、居住地、文化程度及地区人群患病率存在差异。

关键词: 慢性便秘, 成年人, 患病率, Meta分析, 横断面研究, 中国