Chinese General Practice ›› 2023, Vol. 26 ›› Issue (29): 3645-3649.DOI: 10.12114/j.issn.1007-9572.2023.0028
Special Issue: 内分泌代谢性疾病最新文章合集; 老年人群健康最新文章合集; 老年问题最新文章合集
• Original Research • Previous Articles Next Articles
Received:
2022-11-08
Revised:
2023-02-08
Published:
2023-10-15
Online:
2023-02-17
Contact:
YAN Yaqiong
通讯作者:
严亚琼
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0028
指标 | T2DM (n=5 488) | 非T2DM (n=24 572) | 检验统计量值 | P值 |
---|---|---|---|---|
性别(男/女) | 2 325/3 163 | 11 056/ 13 516 | 12.555a | <0.01 |
年龄(岁) | 71.8±5.4 | 71.7±5.6 | 1.369 | 0.181 |
吸烟〔例(%)〕 | 967(17.62) | 5 326(21.68) | 44.561a | <0.01 |
饮酒〔例(%)〕 | 864(15.75) | 4 830(19.67) | 44.680a | <0.01 |
经常锻炼〔例(%)〕 | 3 629(66.13) | 14 496(58.99) | 95.319a | <0.01 |
BMI(kg/m2) | 24.9±3.4 | 23.8±3.4 | 22.119 | <0.01 |
腰围(cm) | 87.59±9.45 | 84.13±9.31 | 24.791 | <0.01 |
收缩压(mmHg) | 135±19 | 133±20 | 4.893 | <0.01 |
舒张压(mmHg) | 80±11 | 81±11 | -6.575 | <0.01 |
ALT〔M(P25,P75),U/L〕 | 16(12,22) | 14(11,19) | -17.210b | <0.01 |
AST〔M(P25,P75),U/L〕 | 18(15,23) | 20(16,24) | -12.862b | <0.01 |
AST/ALT | 1.21±0.51 | 1.43±0.53 | -28.501 | <0.01 |
TC(mmol/L) | 4.65±1.26 | 4.73±0.99 | -4.522 | <0.01 |
TG(mmol/L) | 1.63±1.12 | 1.38±0.88 | 15.588 | <0.01 |
HDL-C〔M(P25,P75),mmol/L〕 | 1.20(1.02,1.42) | 1.31(1.11,1.56) | -22.668b | <0.01 |
LDL-C(mmol/L) | 2.40±0.80 | 2.44±0.82 | -3.353 | <0.01 |
FPG(mmol/L) | 7.22±2.75 | 4.74±0.72 | 66.547 | <0.01 |
Table 1 Comparison of questionnaire survey,physical examination and biochemical test results in T2DM and non-T2DM subjects
指标 | T2DM (n=5 488) | 非T2DM (n=24 572) | 检验统计量值 | P值 |
---|---|---|---|---|
性别(男/女) | 2 325/3 163 | 11 056/ 13 516 | 12.555a | <0.01 |
年龄(岁) | 71.8±5.4 | 71.7±5.6 | 1.369 | 0.181 |
吸烟〔例(%)〕 | 967(17.62) | 5 326(21.68) | 44.561a | <0.01 |
饮酒〔例(%)〕 | 864(15.75) | 4 830(19.67) | 44.680a | <0.01 |
经常锻炼〔例(%)〕 | 3 629(66.13) | 14 496(58.99) | 95.319a | <0.01 |
BMI(kg/m2) | 24.9±3.4 | 23.8±3.4 | 22.119 | <0.01 |
腰围(cm) | 87.59±9.45 | 84.13±9.31 | 24.791 | <0.01 |
收缩压(mmHg) | 135±19 | 133±20 | 4.893 | <0.01 |
舒张压(mmHg) | 80±11 | 81±11 | -6.575 | <0.01 |
ALT〔M(P25,P75),U/L〕 | 16(12,22) | 14(11,19) | -17.210b | <0.01 |
AST〔M(P25,P75),U/L〕 | 18(15,23) | 20(16,24) | -12.862b | <0.01 |
AST/ALT | 1.21±0.51 | 1.43±0.53 | -28.501 | <0.01 |
TC(mmol/L) | 4.65±1.26 | 4.73±0.99 | -4.522 | <0.01 |
TG(mmol/L) | 1.63±1.12 | 1.38±0.88 | 15.588 | <0.01 |
HDL-C〔M(P25,P75),mmol/L〕 | 1.20(1.02,1.42) | 1.31(1.11,1.56) | -22.668b | <0.01 |
LDL-C(mmol/L) | 2.40±0.80 | 2.44±0.82 | -3.353 | <0.01 |
FPG(mmol/L) | 7.22±2.75 | 4.74±0.72 | 66.547 | <0.01 |
指标 | MS (n=8 938) | 非MS (n=21 122) | 检验统计量值 | P值 |
---|---|---|---|---|
性别(男/女) | 3 724/5 214 | 9 657/11 465 | 41.817a | <0.01 |
年龄(岁) | 71.4±5.4 | 71.8±5.7 | -5.196 | <0.01 |
吸烟〔例(%)〕 | 1 638(18.33) | 4 655(22.04) | 52.292a | <0.01 |
饮酒〔例(%)〕 | 1 498(16.77) | 4 196(19.88) | 39.557a | <0.01 |
经常锻炼〔例(%)〕 | 5 842(65.36) | 12 283(58.15) | 136.327a | <0.01 |
BMI(kg/m2) | 26.0±3.1 | 23.2±3.2 | 70.458 | <0.01 |
腰围(cm) | 91.19±8.09 | 82.04±8.60 | 87.855 | <0.01 |
收缩压(mmHg) | 135±19 | 133±20 | 8.918 | <0.01 |
舒张压(mmHg) | 81±11 | 80±11 | 7.440 | <0.01 |
ALT〔M(P25,P75),U/L〕 | 16(12,22) | 14(11,18) | -30.681b | <0.01 |
AST〔M(P25,P75),U/L〕 | 19(16,24) | 19(16,23) | -4.836b | 0.06 |
AST/ALT | 1.22±0.47 | 1.46±0.53 | -39.982 | <0.01 |
TC(mmol/L) | 4.75±1.21 | 4.70±0.97 | 3.355 | <0.01 |
TG(mmol/L) | 2.10±1.26 | 1.14±0.55 | 68.460 | <0.01 |
HDL-C〔M(P25,P75),mmol/L〕 | 1.04 (0.93,1.27) | 1.38 (1.20,1.61) | -79.053b | <0.01 |
LDL-C(mmol/L) | 2.39±0.82 | 2.45±0.81 | -5.853 | <0.01 |
FPG(mmol/L) | 6.02±2.28 | 4.84±1.12 | 46.836 | <0.01 |
Table 2 Comparison of questionnaire survey,physical examination and biochemical test results of MS and non-MS subjects
指标 | MS (n=8 938) | 非MS (n=21 122) | 检验统计量值 | P值 |
---|---|---|---|---|
性别(男/女) | 3 724/5 214 | 9 657/11 465 | 41.817a | <0.01 |
年龄(岁) | 71.4±5.4 | 71.8±5.7 | -5.196 | <0.01 |
吸烟〔例(%)〕 | 1 638(18.33) | 4 655(22.04) | 52.292a | <0.01 |
饮酒〔例(%)〕 | 1 498(16.77) | 4 196(19.88) | 39.557a | <0.01 |
经常锻炼〔例(%)〕 | 5 842(65.36) | 12 283(58.15) | 136.327a | <0.01 |
BMI(kg/m2) | 26.0±3.1 | 23.2±3.2 | 70.458 | <0.01 |
腰围(cm) | 91.19±8.09 | 82.04±8.60 | 87.855 | <0.01 |
收缩压(mmHg) | 135±19 | 133±20 | 8.918 | <0.01 |
舒张压(mmHg) | 81±11 | 80±11 | 7.440 | <0.01 |
ALT〔M(P25,P75),U/L〕 | 16(12,22) | 14(11,18) | -30.681b | <0.01 |
AST〔M(P25,P75),U/L〕 | 19(16,24) | 19(16,23) | -4.836b | 0.06 |
AST/ALT | 1.22±0.47 | 1.46±0.53 | -39.982 | <0.01 |
TC(mmol/L) | 4.75±1.21 | 4.70±0.97 | 3.355 | <0.01 |
TG(mmol/L) | 2.10±1.26 | 1.14±0.55 | 68.460 | <0.01 |
HDL-C〔M(P25,P75),mmol/L〕 | 1.04 (0.93,1.27) | 1.38 (1.20,1.61) | -79.053b | <0.01 |
LDL-C(mmol/L) | 2.39±0.82 | 2.45±0.81 | -5.853 | <0.01 |
FPG(mmol/L) | 6.02±2.28 | 4.84±1.12 | 46.836 | <0.01 |
组别 | 例数 | T2DM | MS | 腹型肥胖 | 高血糖 | 高血压 | TG升高 | HDL-C降低 |
---|---|---|---|---|---|---|---|---|
Q1组 | 8 116 | 1 126(13.87) | 1 658(20.43) | 2 419(29.81) | 1 362(16.78) | 5 357(66.00) | 1 396(17.20) | 1 300(16.02) |
Q2组 | 7 008 | 1 148(16.38) | 1 824(26.03) | 2 658(37.93) | 1 384(19.75) | 4 799(68.48) | 1 524(21.75) | 1 120(15.98) |
Q3组 | 7 438 | 1 406(18.90) | 2 339(31.45) | 3 230(43.43) | 1 672(22.48) | 5 348(71.90) | 1 909(25.67) | 1 396(18.77) |
Q4组 | 7 498 | 1 808(24.11) | 3 117(41.57) | 3 799(50.67) | 2 158(28.78) | 5 625(75.02) | 2 556(34.09) | 1 672(22.30) |
χ2趋势值 | 284.363 | 872.966 | 749.734 | 337.122 | 200.396 | 618.820 | 118.046 | |
P值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
Table 3 Comparison of prevalence of T2DM,MS,abdominal obesity,hyperglycemia,hypertension,elevated TG and decreased HDL-C in quartile groups of ALT
组别 | 例数 | T2DM | MS | 腹型肥胖 | 高血糖 | 高血压 | TG升高 | HDL-C降低 |
---|---|---|---|---|---|---|---|---|
Q1组 | 8 116 | 1 126(13.87) | 1 658(20.43) | 2 419(29.81) | 1 362(16.78) | 5 357(66.00) | 1 396(17.20) | 1 300(16.02) |
Q2组 | 7 008 | 1 148(16.38) | 1 824(26.03) | 2 658(37.93) | 1 384(19.75) | 4 799(68.48) | 1 524(21.75) | 1 120(15.98) |
Q3组 | 7 438 | 1 406(18.90) | 2 339(31.45) | 3 230(43.43) | 1 672(22.48) | 5 348(71.90) | 1 909(25.67) | 1 396(18.77) |
Q4组 | 7 498 | 1 808(24.11) | 3 117(41.57) | 3 799(50.67) | 2 158(28.78) | 5 625(75.02) | 2 556(34.09) | 1 672(22.30) |
χ2趋势值 | 284.363 | 872.966 | 749.734 | 337.122 | 200.396 | 618.820 | 118.046 | |
P值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
组别 | 例数 | T2DM | MS | 腹型肥胖 | 高血糖 | 高血压 | TG升高 | HDL-C降低 |
---|---|---|---|---|---|---|---|---|
q1组 | 7 386 | 2 193(29.69) | 3 463(46.89) | 4 106(55.60) | 2 521(34.13) | 5 640(76.36) | 2 552(34.55) | 1 954(26.46) |
q2组 | 7 698 | 1 548(20.11) | 2 613(33.94) | 3 494(45.39) | 1 835(23.84) | 5 537(71.93) | 2 090(27.15) | 1 590(20.65) |
q3组 | 7 529 | 1 048(13.92) | 1 750(23.24) | 2 662(35.36) | 1 309(17.39) | 5 100(67.73) | 1 599(21.24) | 1 113(14.78) |
q4组 | 7 447 | 699(9.39) | 1 112(14.93) | 1 844(24.76) | 911(12.23) | 4853(65.17) | 1 144(15.36) | 831(11.16) |
χ2趋势值 | 1 119.388 | 2 018.716 | 1 624.595 | 1 129.864 | 135.044 | 807.758 | 667.304 | |
P值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
Table 4 Comparison of prevalence of T2DM,MS,abdominal obesity,hyperglycemia,hypertension,elevated TG and decreased HDL-C in quartile groups of AST/ALT ratio
组别 | 例数 | T2DM | MS | 腹型肥胖 | 高血糖 | 高血压 | TG升高 | HDL-C降低 |
---|---|---|---|---|---|---|---|---|
q1组 | 7 386 | 2 193(29.69) | 3 463(46.89) | 4 106(55.60) | 2 521(34.13) | 5 640(76.36) | 2 552(34.55) | 1 954(26.46) |
q2组 | 7 698 | 1 548(20.11) | 2 613(33.94) | 3 494(45.39) | 1 835(23.84) | 5 537(71.93) | 2 090(27.15) | 1 590(20.65) |
q3组 | 7 529 | 1 048(13.92) | 1 750(23.24) | 2 662(35.36) | 1 309(17.39) | 5 100(67.73) | 1 599(21.24) | 1 113(14.78) |
q4组 | 7 447 | 699(9.39) | 1 112(14.93) | 1 844(24.76) | 911(12.23) | 4853(65.17) | 1 144(15.36) | 831(11.16) |
χ2趋势值 | 1 119.388 | 2 018.716 | 1 624.595 | 1 129.864 | 135.044 | 807.758 | 667.304 | |
P值 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 |
模型 | T2DM | MS | ||
---|---|---|---|---|
OR(95%CI) | P值 | OR(95%CI) | P值 | |
模型1 | ||||
Q1组 | 1.000 | 1.000 | ||
Q2组 | 1.217(1.053,1.407) | <0.01 | 1.431(1.261,1.624) | <0.01 |
Q3组 | 1.432(1.250,1.641) | <0.01 | 1.915(1.702,2.156) | <0.01 |
Q4组 | 1.978(1.736,2.253) | <0.01 | 2.973(2.652,3.333) | <0.01 |
模型2 | ||||
Q1组 | 1.000 | 1.000 | ||
Q2组 | 1.134(1.036,1.242) | <0.01 | 1.115(1.028,1.210) | <0.01 |
Q3组 | 1.298(1.188,1.418) | <0.01 | 1.307(1.208,1.415) | <0.01 |
Q4组 | 1.696(1.555,1.849) | <0.01 | 1.829(1.692,1.978) | <0.01 |
Table 5 Multivariate Logistic regression analysis of the association of ALT with T2DM and MS
模型 | T2DM | MS | ||
---|---|---|---|---|
OR(95%CI) | P值 | OR(95%CI) | P值 | |
模型1 | ||||
Q1组 | 1.000 | 1.000 | ||
Q2组 | 1.217(1.053,1.407) | <0.01 | 1.431(1.261,1.624) | <0.01 |
Q3组 | 1.432(1.250,1.641) | <0.01 | 1.915(1.702,2.156) | <0.01 |
Q4组 | 1.978(1.736,2.253) | <0.01 | 2.973(2.652,3.333) | <0.01 |
模型2 | ||||
Q1组 | 1.000 | 1.000 | ||
Q2组 | 1.134(1.036,1.242) | <0.01 | 1.115(1.028,1.210) | <0.01 |
Q3组 | 1.298(1.188,1.418) | <0.01 | 1.307(1.208,1.415) | <0.01 |
Q4组 | 1.696(1.555,1.849) | <0.01 | 1.829(1.692,1.978) | <0.01 |
模型 | T2DM | MS | ||
---|---|---|---|---|
OR(95%CI) | P值 | OR(95%CI) | P值 | |
模型1 | ||||
q1组 | 1.000 | 1.000 | ||
q2组 | 0.572(0.511,0.641) | <0.01 | 0.529(0.480,0.583) | <0.01 |
q3组 | 0.387(0.341,0.440) | <0.01 | 0.307(0.275,0.342) | <0.01 |
q4组 | 0.222(0.191,0.258) | <0.01 | 0.149(0.131,0.170) | <0.01 |
模型2 | ||||
q1组 | 1.000 | 1.000 | ||
q2组 | 0.603(0.559,0.651) | <0.01 | 0.654(0.609,0.701) | <0.01 |
q3组 | 0.398(0.366,0.433) | <0.01 | 0.440(0.408,0.475) | <0.01 |
q4组 | 0.270(0.244,0.298) | <0.01 | 0.324(0.297,0.353) | <0.01 |
Table 6 Multivariate Logistic regression analysis of the association of AST/ALT ratio with T2DM and MS
模型 | T2DM | MS | ||
---|---|---|---|---|
OR(95%CI) | P值 | OR(95%CI) | P值 | |
模型1 | ||||
q1组 | 1.000 | 1.000 | ||
q2组 | 0.572(0.511,0.641) | <0.01 | 0.529(0.480,0.583) | <0.01 |
q3组 | 0.387(0.341,0.440) | <0.01 | 0.307(0.275,0.342) | <0.01 |
q4组 | 0.222(0.191,0.258) | <0.01 | 0.149(0.131,0.170) | <0.01 |
模型2 | ||||
q1组 | 1.000 | 1.000 | ||
q2组 | 0.603(0.559,0.651) | <0.01 | 0.654(0.609,0.701) | <0.01 |
q3组 | 0.398(0.366,0.433) | <0.01 | 0.440(0.408,0.475) | <0.01 |
q4组 | 0.270(0.244,0.298) | <0.01 | 0.324(0.297,0.353) | <0.01 |
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