Chinese General Practice ›› 2024, Vol. 27 ›› Issue (12): 1487-1492.DOI: 10.12114/j.issn.1007-9572.2023.0515
• Original Research • Previous Articles Next Articles
Received:
2023-06-25
Revised:
2023-09-12
Published:
2024-04-20
Online:
2024-01-23
Contact:
ZHAO Hongbo
通讯作者:
赵红波
作者简介:
基金资助:
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2023.0515
组别 | 例数 | 每周CSBM积分(分) | 中医证候积分(分) | 标记物排出率(%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 48 h | 72 h | |||||
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | |||||||
对照组 | 50 | 2.71±0.32 | 1.53±0.20a | 24.97±4.15 | 22.65±3.73 | 19.31±4.87 | 45.90±6.96a | 26.85±5.72 | 60.42±8.31a | |
观察组 | 50 | 2.84±0.26 | 0.89±0.17a | 23.63±4.09 | 13.87±2.28a | 20.28±5.43 | 62.65±8.75a | 25.59±5.64 | 77.18±10.62a | |
t值 | 0.139 | 5.910 | 0.703 | 5.528 | 0.619 | 11.316 | 1.074 | 13.192 | ||
P值 | 0.359 | 0.032 | 0.448 | 0.027 | 0.380 | 0.011 | 0.625 | 0.006 |
Table 1 Comparison of weekly CSBM score,TCM syndrome score and exclusion rate score between the two groups
组别 | 例数 | 每周CSBM积分(分) | 中医证候积分(分) | 标记物排出率(%) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 48 h | 72 h | |||||
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | |||||||
对照组 | 50 | 2.71±0.32 | 1.53±0.20a | 24.97±4.15 | 22.65±3.73 | 19.31±4.87 | 45.90±6.96a | 26.85±5.72 | 60.42±8.31a | |
观察组 | 50 | 2.84±0.26 | 0.89±0.17a | 23.63±4.09 | 13.87±2.28a | 20.28±5.43 | 62.65±8.75a | 25.59±5.64 | 77.18±10.62a | |
t值 | 0.139 | 5.910 | 0.703 | 5.528 | 0.619 | 11.316 | 1.074 | 13.192 | ||
P值 | 0.359 | 0.032 | 0.448 | 0.027 | 0.380 | 0.011 | 0.625 | 0.006 |
组别 | 例数 | 5-HT(μg/L) | GAS(ng/L) | VIP(ng/L) | SS(ng/L) | ||||
---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | ||
对照组 | 50 | 51.70±10.14 | 78.86±14.35a | 21.77±6.34 | 23.95±7.87 | 82.99±8.92 | 70.04±8.04a | 59.34±10.02 | 46.98±7.51a |
观察组 | 50 | 50.94±8.25 | 67.19±11.28a | 20.69±5.28 | 47.19±8.29a | 81.38±7.50 | 47.10±6.82a | 58.28±9.39 | 33.19±5.25a |
t值 | 0.639 | 10.711 | 0.811 | 13.528 | 1.168 | 15.306 | 0.807 | 9.192 | |
P值 | 0.250 | 0.014 | 0.375 | <0.001 | 0.497 | <0.001 | 0.526 | 0.027 |
Table 2 Comparison of gastrointestinal neurohormone levels between the two groups
组别 | 例数 | 5-HT(μg/L) | GAS(ng/L) | VIP(ng/L) | SS(ng/L) | ||||
---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | ||
对照组 | 50 | 51.70±10.14 | 78.86±14.35a | 21.77±6.34 | 23.95±7.87 | 82.99±8.92 | 70.04±8.04a | 59.34±10.02 | 46.98±7.51a |
观察组 | 50 | 50.94±8.25 | 67.19±11.28a | 20.69±5.28 | 47.19±8.29a | 81.38±7.50 | 47.10±6.82a | 58.28±9.39 | 33.19±5.25a |
t值 | 0.639 | 10.711 | 0.811 | 13.528 | 1.168 | 15.306 | 0.807 | 9.192 | |
P值 | 0.250 | 0.014 | 0.375 | <0.001 | 0.497 | <0.001 | 0.526 | 0.027 |
组别 | 例数 | 便意感 | 粪便性状 | 排便时长 | 排便不尽 | 排便无力 | 腹胀 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | ||
对照组 | 50 | 3.02±1.42 | 2.29±0.53a | 4.61±1.04 | 4.37±1.12 | 3.09±0.95 | 2.41±0.65a | 2.84±0.79 | 2.29±0.35a | 3.11±0.58 | 2.99±0.56 | 2.90±0.62 | 2.28±0.49a |
观察组 | 50 | 3.08±1.31 | 1.76±0.44a | 4.53±0.92 | 2.65±0.58a | 3.04±0.77 | 1.52±0.26a | 2.95±0.85 | 1.38±0.31a | 3.07±0.66 | 1.58±0.39a | 2.86±0.63 | 1.69±0.37a |
t值 | 0.539 | 4.910 | 0.672 | 3.528 | 0.912 | 5.214 | 1.639 | 7.910 | 2.073 | 4.328 | 3.169 | 5.822 | |
P值 | 0.406 | 0.036 | 0.187 | 0.029 | 0.634 | 0.017 | 0.312 | 0.014 | 0.264 | 0.025 | 0.187 | 0.029 |
Table 3 Comparison of clinical symptom scores of constipation in two groups
组别 | 例数 | 便意感 | 粪便性状 | 排便时长 | 排便不尽 | 排便无力 | 腹胀 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | 治疗前 | 治疗4周后 | ||
对照组 | 50 | 3.02±1.42 | 2.29±0.53a | 4.61±1.04 | 4.37±1.12 | 3.09±0.95 | 2.41±0.65a | 2.84±0.79 | 2.29±0.35a | 3.11±0.58 | 2.99±0.56 | 2.90±0.62 | 2.28±0.49a |
观察组 | 50 | 3.08±1.31 | 1.76±0.44a | 4.53±0.92 | 2.65±0.58a | 3.04±0.77 | 1.52±0.26a | 2.95±0.85 | 1.38±0.31a | 3.07±0.66 | 1.58±0.39a | 2.86±0.63 | 1.69±0.37a |
t值 | 0.539 | 4.910 | 0.672 | 3.528 | 0.912 | 5.214 | 1.639 | 7.910 | 2.073 | 4.328 | 3.169 | 5.822 | |
P值 | 0.406 | 0.036 | 0.187 | 0.029 | 0.634 | 0.017 | 0.312 | 0.014 | 0.264 | 0.025 | 0.187 | 0.029 |
组别 | 例数 | 临床疗效 | 3个月复发率 | |||
---|---|---|---|---|---|---|
痊愈 | 显效 | 有效 | 无效 | |||
对照组 | 50 | 27(54.0) | 6(12.0) | 3(6.0) | 14(28.0) | 9(12.0) |
观察组 | 50 | 35(70.0) | 5(10.0) | 4(8.0) | 6(12.0) | 3(6.0) |
Table 4 Comparison of clinical efficacy between the two groups of patients
组别 | 例数 | 临床疗效 | 3个月复发率 | |||
---|---|---|---|---|---|---|
痊愈 | 显效 | 有效 | 无效 | |||
对照组 | 50 | 27(54.0) | 6(12.0) | 3(6.0) | 14(28.0) | 9(12.0) |
观察组 | 50 | 35(70.0) | 5(10.0) | 4(8.0) | 6(12.0) | 3(6.0) |
[1] | |
[2] |
夏晨曦,周玲,秦珂馨,等. 基于肠道菌群探讨中医药治疗老年便秘[J]. 中国老年学杂志,2022,42(1):251-254. DOI:10.3969/j.issn.1005-9202.2022.01.066.
|
[3] |
曹正清,王浩,谷云飞. 朱秉宜运用"魄门为五脏使"理论治疗老年便秘经验[J]. 中国中医基础医学杂志,2020,26(9):1392-1395.
|
[4] |
中华医学会,中华医学会杂志社,中华医学会消化病学分会,等. 慢性便秘基层诊疗指南(2019年)[J]. 中华全科医师杂志,2020,19(12):1100-1107. DOI:10.3760/cma.j.cn114798-20201030-01109.
|
[5] |
张声生,沈洪,张露,等. 便秘中医诊疗专家共识意见(2017)[J]. 中医杂志,2017,58(15):1345-1350. DOI:10.13288/j.11-2166/r.2017.15.023.
|
[6] |
蓝菲,袁文贝. 通便汤联合复方嗜酸乳杆菌片治疗功能性便秘临床疗效分析[J]. 中华中医药学刊,2021,39(12):171-174. DOI:10.13193/j.issn.1673-7717.2021.12.040.
|
[7] |
孙兴伟,唐远山,沙静涛,等.增液汤加味治疗功能性便秘阴液亏虚证的临床疗效观察[J].中华中医药杂志,2022,37(3):1818-1821.
|
[8] |
中华医学会消化病学分会胃肠动力学组,中华医学会消化病学分会功能性胃肠病协作组. 中国慢性便秘专家共识意见(2019,广州)[J]. 中华消化杂志,2019,39(9):577-598. DOI:10.3760/cma.j.issn.0254-1432.2019.09.001.
|
[9] |
贾梦鑫,于猛,秦玲玲,等. 生白术多糖对洛哌丁胺诱导大鼠便秘的改善作用研究[J]. 中草药,2022,53(24):7808-7815. DOI:10.7501/j.issn.0253-2670.2022.24.018.
|
[10] |
施敏,刘富林,夏旭婷,等. 基于网络药理学探讨黄芪治疗慢传输型便秘的作用机制[J]. 世界中医药,2023,18(15):2128-2133.
|
[11] |
张娟,王建民. 基于"肺与大肠相表里"理论探讨益气健脾通便方治疗慢传输型便秘的疗效观察[J]. 辽宁中医杂志,2022,49(8):73-76. DOI:10.13192/j.issn.1000-1719.2022.08.021.
|
[12] |
王潇,王婷,张晨,等. 基于代谢组学研究厚朴"发汗"前后对胃肠动力障碍大鼠的影响[J]. 中国中药杂志,2019,44(6):1170-1178. DOI:10.19540/j.cnki.cjcmm.20181225.001.
|
[13] |
王潞潞,彭艳,宋观礼,等. 调神法治疗功能性胃肠病的有效药物配伍发现研究[J]. 世界科学技术-中医药现代化,2023,25(5):1561-1568.
|
[14] |
马珂,刘芳,寿雅琨,等. 国医大师刘祖贻治疗不寐的学术特色及用药规律分析[J]. 中国中药杂志,2019,44(12):2607-2615. DOI:10.19540/j.cnki.cjcmm.20190225.001.
|
[15] |
孙琰婷,厉越,陈倚,等. 基于数据挖掘的陆金根治疗功能性便秘组方用药规律研究[J]. 上海中医药杂志,2022,56(11):21-28,32. DOI:10.16305/j.1007-1334.2022.2203029.
|
[16] |
李磊磊,刘安,熊之焰. 基于数据挖掘研究《景岳全书》治疗便秘用药规律[J]. 山西中医,2022,38(1):57-59. DOI:10.20002/j.issn.1000-7156.2022.01.021.
|
[17] |
王梁凤,张小飞,李慧婷,等. 基于数据挖掘的芳香类中药治疗便秘高频次使用药对"陈皮-木香"网络药理学研究[J]. 中国中药杂志,2020,45(9):2103-2114. DOI:10.19540/j.cnki.cjcmm.20200221.304.
|
[18] | |
[19] | |
[20] |
汤水华,李思汉,林翔英,等. 理气通便方对功能性便秘气滞证大鼠脑肠肽的影响[J]. 北京中医药大学学报,2021,44(7):615-624. DOI:10.3969/j.issn.1006-2157.2021.07.006.
|
[21] |
孔鹏飞,王秋晓,王邦林,等. 加味逍遥散治疗肝郁气滞型慢传输型便秘的临床研究[J]. 中药新药与临床药理,2021,32(10):1531-1536. DOI:10.19378/j.issn.1003-9783.2021.10.017.
|
[22] |
刘芳,张智彬,王邦林,等. 加味枳术汤治疗气阴两虚型老年原发性便秘的临床疗效[J]. 中国实验方剂学杂志,2021,27(17):99-105. DOI:10.13422/j.cnki.syfjx.20211790.
|
[23] |
郭振科,李志坚,刘宇虎. 益气健脾通便方治疗肺脾气虚型慢传输型便秘效果及对胃饥饿素、肿瘤坏死因子-α变化的研究[J]. 中华中医药学刊,2022,40(5):119-122. DOI:10.13193/j.issn.1673-7717.2022.05.029.
|
[1] | GAO Ying, XU Xinyi, LIU Yang, YANG Xiaokun. Research on the Development of Atherosclerotic Cardiovascular Disease Prediction Model for the Elderly Based on TCM Constitution [J]. Chinese General Practice, 2024, 27(15): 1878-1885. |
[2] | WU Meiqian, XIAO Jin, LI Feifei, HU Rongrong, LIU Caixia. 24-hour Movement Behaviors: a New Direction for the Study of Factors Affecting Health of the Elderly [J]. Chinese General Practice, 2024, 27(15): 1911-1916. |
[3] | LIU Ying, JIANG Juncheng, JING Huiquan. Correlation of Regional Differences in the Prevalence and Types of Chronic Diseases among Middle-aged and Elderly People with Health Resources Allocation in China [J]. Chinese General Practice, 2024, 27(12): 1452-1459. |
[4] | KANG Jing, ZHANG Ci, ZHANG Zhengyi. Distribution and Influencing Factors of Chronic Comorbidities among Middle-aged Inpatients in General Practice Department of Tertiary General Hospitals [J]. Chinese General Practice, 2024, 27(11): 1310-1315. |
[5] | SHI Yushuang, WANG Huihua, LI Yan, LU Ping, SONG Wei, PAN Guijun. Analysis of the Effectiveness of Different Atrial Fibrillation Screening Methods in the Community-based Elderly Population [J]. Chinese General Practice, 2024, 27(11): 1316-1319. |
[6] | XU Li, GE Jing, YU Peng, YU Ying. Shifts in Chronic Disease and Comorbidity Patterns among Chinese Older Adults: an Analysis Based on the China Health and Retirement Longitudinal Study [J]. Chinese General Practice, 2024, 27(11): 1296-1302. |
[7] | XIE Yi, XU Junma, XU Fangqin, LI Chao, CHEN Chen, SHAO Chan. Predictive Value of Sarcopenia Index for Prognosis in Elderly Patients with Acute Ischemic Stroke [J]. Chinese General Practice, 2024, 27(11): 1326-1330. |
[8] | WANG Wenjuan, WANG Rui, ZENG Hongji, LIU Yahui, WEI Shufan, TIAN Qingfeng. Relationship between Serum Liver Transaminase and Metabolic Syndrome in the Aged Based on Restrictive Cubic Spline Model [J]. Chinese General Practice, 2024, 27(11): 1337-1342. |
[9] | DAI Zhenwei, ZHANG Ling, ZHANG Haoran, XIAO Weijun, WANG Hao, HUANG Yiman, JING Shu, CHEN Xu, FU Jiaqi, WU Yijin, GAO Lei, SU Xiaoyou. Influencing Factors of Blood Glucose Monitoring in Middle-aged and Elderly Patients with Type-2 Diabetes Mellitus in Rural Areas [J]. Chinese General Practice, 2024, 27(10): 1194-1200. |
[10] | YU Xinyan, SU Peng, YUAN Xiaojing, JIANG Qingru, YANG Jianyun, ZHAO Xudong, WANG Yifan, ZHANG Haicheng. A Study on the Factors Influencing the Comprehensive Risk of Cardiovascular Disease in Elderly Patients with Chronic Disease in Primary Care [J]. Chinese General Practice, 2024, 27(10): 1186-1193. |
[11] | ZHU Chenli, ZHANG Tiancheng, LI Hui, FENG Zhengwen, CHEN Xiaolei, SHAO Shuang, DU Juan. The Development of Quality Indicator System for the Home Care Services for the Disabled Elderly in Beijing [J]. Chinese General Practice, 2024, 27(10): 1215-1220. |
[12] | GAO Chuan, LI Qingyin, KE Dandan, ZHOU Yuyu, ZHANG Yuyang, HE Zhong. The Utilization of Health Checkup Services among People Aged 45 and above in China: a National Cross-sectional Survey Based on CHARLS 2018 [J]. Chinese General Practice, 2024, 27(10): 1179-1185. |
[13] | ZENG Lingcong, ZHANG Longju, ZHOU Ling, ZHANG Wei, DAI Meng, HUANG Yin, HUANG Yi. Analysis of the Predictive Value of 4-level Clinical Pretest Probability Score in Elderly Patients with Acute Pulmonary Embolism [J]. Chinese General Practice, 2024, 27(09): 1062-1067. |
[14] | FAN Jing, WEI Shan, LI Liqiu, ZHENG Xiuli, LI Yan, NIU Jianying, WANG Ling, XU Chengyan. Investigation on the Incidence and Influencing Factors of Proteinuria and Renal Dysfunction in Community-dwelling Elderly Population [J]. Chinese General Practice, 2024, 27(09): 1048-1053. |
[15] | XU Yanan, LI Wenjuan, ZHAO Shuqin, TANG Yuji, YUAN Fuqiang, ZHAO Kunpeng. A Qualitative Study on the Social Isolation Experience of Young and Middle-aged Patients with Schizophrenia in Remission [J]. Chinese General Practice, 2024, 27(09): 1088-1094. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||