Chinese General Practice ›› 2023, Vol. 26 ›› Issue (17): 2114-2119.DOI: 10.12114/j.issn.1007-9572.2022.0799
Special Issue: 老年问题最新文章合集
• Original Research • Previous Articles Next Articles
Received:
2022-08-08
Revised:
2023-02-13
Published:
2023-06-15
Online:
2023-03-01
Contact:
YU Wei
通讯作者:
喻伟
作者简介:
基金资助:
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URL: https://www.chinagp.net/EN/10.12114/j.issn.1007-9572.2022.0799
组别 | 例数 | 血液炎症因子a | 凝血因子a | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CRP (µg/L) | 纤维蛋白原(µg/L) | P选择蛋白(ng/L) | MCP-1 (ng/L) | IL-1β (ng/L) | IL-6 (ng/L) | TNF-α (ng/L) | MPO (µg/L) | sCD40L (ng/L) | PAI-1 (ng/L) | t-PA (ng/L) | ||
假净化器 | 24 | 2 084.7±426.5 | 993.3±195.6 | 4 461.6±575.5 | 240.6±27.1 | 53.1±5.8 | 20.0±2.8 | 314.0±74.4 | 78.2±10.8 | 628.4±146.6 | 657.4±110.6 | 211.7±22.7 |
真净化器 | 24 | 1 864.3±397.5 | 859.5±174.1 | 4 225.6±522.5 | 198.6±21.8 | 51.3±5.8 | 19.3±2.7 | 293.7±70.7 | 65.2±12.4 | 610.3±18.1 | 564.8±129.6 | 183.6±29.7 |
组别 | D-二聚体(µg/L) | SBP (mm Hg) | DBP (mm Hg) | 心率(次/min) | 肺功能及肺部炎症b | 氧化应激因子a | ||||||
PEF (L/min) | FEV1 (L) | FVC (L) | FeNO (ppb) | ROS (µg/L) | GSH (ng/L) | |||||||
假净化器 | 3 728.4±706.7 | 145±30 | 87±13 | 74±13 | 104.5±32.4 | 0.87±0.45 | 1.03±0.62 | 18.9±10.0 | 11.5±1.4 | 76.6±11.8 | ||
真净化器 | 3 470.3±536.9 | 142±27 | 88±15 | 70±10 | 96.9±41.6 | 0.87±0.48 | 1.08±0.70 | 16.0±9.7 | 11.0±1.3 | 82.2±12.4 |
Table 1 Health indexes in the real purifiers group and sham purifiers group during the intervention period
组别 | 例数 | 血液炎症因子a | 凝血因子a | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CRP (µg/L) | 纤维蛋白原(µg/L) | P选择蛋白(ng/L) | MCP-1 (ng/L) | IL-1β (ng/L) | IL-6 (ng/L) | TNF-α (ng/L) | MPO (µg/L) | sCD40L (ng/L) | PAI-1 (ng/L) | t-PA (ng/L) | ||
假净化器 | 24 | 2 084.7±426.5 | 993.3±195.6 | 4 461.6±575.5 | 240.6±27.1 | 53.1±5.8 | 20.0±2.8 | 314.0±74.4 | 78.2±10.8 | 628.4±146.6 | 657.4±110.6 | 211.7±22.7 |
真净化器 | 24 | 1 864.3±397.5 | 859.5±174.1 | 4 225.6±522.5 | 198.6±21.8 | 51.3±5.8 | 19.3±2.7 | 293.7±70.7 | 65.2±12.4 | 610.3±18.1 | 564.8±129.6 | 183.6±29.7 |
组别 | D-二聚体(µg/L) | SBP (mm Hg) | DBP (mm Hg) | 心率(次/min) | 肺功能及肺部炎症b | 氧化应激因子a | ||||||
PEF (L/min) | FEV1 (L) | FVC (L) | FeNO (ppb) | ROS (µg/L) | GSH (ng/L) | |||||||
假净化器 | 3 728.4±706.7 | 145±30 | 87±13 | 74±13 | 104.5±32.4 | 0.87±0.45 | 1.03±0.62 | 18.9±10.0 | 11.5±1.4 | 76.6±11.8 | ||
真净化器 | 3 470.3±536.9 | 142±27 | 88±15 | 70±10 | 96.9±41.6 | 0.87±0.48 | 1.08±0.70 | 16.0±9.7 | 11.0±1.3 | 82.2±12.4 |
健康指标 | 改变百分比(%) | 95%CI(%) | SE | t值 | P值 | 健康指标 | 改变百分比(%) | 95%CI(%) | SE | t值 | P值 |
---|---|---|---|---|---|---|---|---|---|---|---|
血液炎症指标 | 血压 | ||||||||||
CRP | -9.9 | (-19.2,0.6) | 109.46 | -1.950 | 0.081 | SBP | -1.8 | (-5.9,2.4) | 3.06 | -1.060 | 0.288 |
纤维蛋白原 | -15.1 | (-23.1,-6.3) | 46.23 | -3.380 | 0.001 | DBP | 1.1 | (-3.0,5.3) | 1.83 | 0.590 | 0.556 |
P选择蛋白 | -4.7 | (-9.5,0.5) | 114.11 | -1.890 | 0.079 | 心率 | -5.9 | (-10.1,-1.4) | 1.69 | -2.800 | 0.005 |
MCP-1 | -17.7 | (-22.8,-12.2) | 7.16 | -6.050 | <0.001 | 肺功能及肺部炎症 | |||||
IL-1β | -3.4 | (-8.4,1.8) | 1.41 | -1.290 | 0.197 | PEF | -7.1 | (-21.9,10.4) | 9.07 | -0.535 | 0.593 |
IL-6 | -3.7 | (-10.7,3.9) | 0.75 | -0.964 | 0.335 | FEV1 | -0.3 | (-12.8,14.1) | 0.06 | 0.173 | 0.863 |
TNF-α | -5.9 | (-18.5,8.6) | 21.13 | -0.890 | 0.374 | FVC | 3.6 | (-10.3,19.7) | 0.09 | 0.870 | 0.386 |
MPO | -17.2 | (-23.9,-9.8) | 2.98 | -4.430 | <0.001 | FeNO | -14.0 | (-30.2,6.0) | 2.45 | -1.000 | 0.317 |
凝血因子 | 氧化应激因子 | ||||||||||
sCD40L | -2.2 | (-13.9,11.0) | 40.13 | -0.457 | 0.648 | ROS | -1.5 | (-7.7,5.2) | 0.36 | -0.520 | 0.606 |
PAI-1 | -14.9 | (-21.1,-8.2) | 22.13 | -4.200 | <0.001 | GSH | 6.8 | (-2.2,16.6) | 3.55 | 1.480 | 0.140 |
t-PA | -13.5 | (-18.7,-8.0) | 5.83 | -4.770 | <0.001 | ||||||
D-二聚体 | -8.9 | (-17.3,0.4) | 173.06 | -2.060 | 0.063 |
Table 2 Linear mixed-effect model results of health indexes of the elderly under real and sham purification
健康指标 | 改变百分比(%) | 95%CI(%) | SE | t值 | P值 | 健康指标 | 改变百分比(%) | 95%CI(%) | SE | t值 | P值 |
---|---|---|---|---|---|---|---|---|---|---|---|
血液炎症指标 | 血压 | ||||||||||
CRP | -9.9 | (-19.2,0.6) | 109.46 | -1.950 | 0.081 | SBP | -1.8 | (-5.9,2.4) | 3.06 | -1.060 | 0.288 |
纤维蛋白原 | -15.1 | (-23.1,-6.3) | 46.23 | -3.380 | 0.001 | DBP | 1.1 | (-3.0,5.3) | 1.83 | 0.590 | 0.556 |
P选择蛋白 | -4.7 | (-9.5,0.5) | 114.11 | -1.890 | 0.079 | 心率 | -5.9 | (-10.1,-1.4) | 1.69 | -2.800 | 0.005 |
MCP-1 | -17.7 | (-22.8,-12.2) | 7.16 | -6.050 | <0.001 | 肺功能及肺部炎症 | |||||
IL-1β | -3.4 | (-8.4,1.8) | 1.41 | -1.290 | 0.197 | PEF | -7.1 | (-21.9,10.4) | 9.07 | -0.535 | 0.593 |
IL-6 | -3.7 | (-10.7,3.9) | 0.75 | -0.964 | 0.335 | FEV1 | -0.3 | (-12.8,14.1) | 0.06 | 0.173 | 0.863 |
TNF-α | -5.9 | (-18.5,8.6) | 21.13 | -0.890 | 0.374 | FVC | 3.6 | (-10.3,19.7) | 0.09 | 0.870 | 0.386 |
MPO | -17.2 | (-23.9,-9.8) | 2.98 | -4.430 | <0.001 | FeNO | -14.0 | (-30.2,6.0) | 2.45 | -1.000 | 0.317 |
凝血因子 | 氧化应激因子 | ||||||||||
sCD40L | -2.2 | (-13.9,11.0) | 40.13 | -0.457 | 0.648 | ROS | -1.5 | (-7.7,5.2) | 0.36 | -0.520 | 0.606 |
PAI-1 | -14.9 | (-21.1,-8.2) | 22.13 | -4.200 | <0.001 | GSH | 6.8 | (-2.2,16.6) | 3.55 | 1.480 | 0.140 |
t-PA | -13.5 | (-18.7,-8.0) | 5.83 | -4.770 | <0.001 | ||||||
D-二聚体 | -8.9 | (-17.3,0.4) | 173.06 | -2.060 | 0.063 |
健康指标 | 男 | 女 | ||||||
---|---|---|---|---|---|---|---|---|
改变百分比(%) | SE | t值 | P值 | 改变百分比(%) | SE | t值 | P值 | |
CRP | -23.43 | 130.67 | -4.040 | <0.001 | 7.69 | 110.86 | 1.120 | 0.262 |
纤维蛋白原 | -17.00 | 60.44 | -2.870 | 0.004 | -11.89 | 61.41 | -2.058 | 0.040 |
P选择蛋白 | -5.87 | 163.06 | -0.610 | 0.107 | -4.43 | 167.36 | -1.250 | 0.210 |
MCP-1 | -22.54 | 6.53 | -8.660 | <0.001 | -12.75 | 12.84 | -2.370 | 0.018 |
IL-1β | -6.14 | 1.63 | -1.980 | 0.048 | 0.32 | 2.52 | 0.020 | 0.984 |
IL-6 | -0.31 | 0.93 | 0.026 | 0.979 | -5.57 | 1.28 | -0.919 | 0.358 |
TNF-α | -7.44 | 30.28 | -0.793 | 0.428 | -3.72 | 34.37 | -0.342 | 0.732 |
MPO | -17.07 | 3.29 | -0.403 | <0.001 | -18.41 | 5.47 | -2.653 | 0.110 |
sCD40L | -3.78 | 59.61 | -0.480 | 0.631 | 1.05 | 62.63 | 0.033 | 0.974 |
PAI-1 | -22.74 | 25.75 | -5.597 | <0.001 | -7.29 | 15.86 | -3.041 | 0.002 |
t-PA | -12.47 | 7.91 | -3.229 | 0.001 | -13.96 | 9.32 | -3.110 | 0.002 |
D-二聚体 | -6.12 | 261.02 | -0.913 | 0.361 | -12.20 | 251.43 | -1.970 | 0.089 |
SBP | -0.72 | 4.82 | -0.330 | 0.741 | -3.33 | 4.48 | -1.190 | 0.235 |
DBP | -0.37 | 2.22 | -0.193 | 0.847 | 1.15 | 3.01 | 0.489 | 0.422 |
心率 | -5.06 | 2.81 | -1.390 | 0.165 | -6.69 | 2.10 | -2.810 | 0.005 |
PEF | -4.26 | 14.48 | -0.090 | 0.927 | -8.48 | 8.99 | -0.704 | 0.482 |
FEV1 | 0.31 | 0.09 | 0.370 | 0.780 | 0.43 | 0.67 | 0.062 | 0.950 |
FVC | 4.83 | 0.16 | 0.744 | 0.457 | 2.76 | 0.08 | 0.410 | 0.682 |
FeNO | -17.34 | 2.83 | -1.220 | 0.223 | -8.84 | 4.70 | -0.240 | 0.809 |
ROS | -0.08 | 0.56 | 0.383 | 0.702 | -4.36 | 0.37 | -1.362 | 0.173 |
GSH | -0.10 | 5.78 | 0.652 | 0.514 | 8.97 | 4.53 | 1.482 | 0.138 |
Table 3 Linear mixed-effect model results of health indexes of male and female older adults under real and sham purification
健康指标 | 男 | 女 | ||||||
---|---|---|---|---|---|---|---|---|
改变百分比(%) | SE | t值 | P值 | 改变百分比(%) | SE | t值 | P值 | |
CRP | -23.43 | 130.67 | -4.040 | <0.001 | 7.69 | 110.86 | 1.120 | 0.262 |
纤维蛋白原 | -17.00 | 60.44 | -2.870 | 0.004 | -11.89 | 61.41 | -2.058 | 0.040 |
P选择蛋白 | -5.87 | 163.06 | -0.610 | 0.107 | -4.43 | 167.36 | -1.250 | 0.210 |
MCP-1 | -22.54 | 6.53 | -8.660 | <0.001 | -12.75 | 12.84 | -2.370 | 0.018 |
IL-1β | -6.14 | 1.63 | -1.980 | 0.048 | 0.32 | 2.52 | 0.020 | 0.984 |
IL-6 | -0.31 | 0.93 | 0.026 | 0.979 | -5.57 | 1.28 | -0.919 | 0.358 |
TNF-α | -7.44 | 30.28 | -0.793 | 0.428 | -3.72 | 34.37 | -0.342 | 0.732 |
MPO | -17.07 | 3.29 | -0.403 | <0.001 | -18.41 | 5.47 | -2.653 | 0.110 |
sCD40L | -3.78 | 59.61 | -0.480 | 0.631 | 1.05 | 62.63 | 0.033 | 0.974 |
PAI-1 | -22.74 | 25.75 | -5.597 | <0.001 | -7.29 | 15.86 | -3.041 | 0.002 |
t-PA | -12.47 | 7.91 | -3.229 | 0.001 | -13.96 | 9.32 | -3.110 | 0.002 |
D-二聚体 | -6.12 | 261.02 | -0.913 | 0.361 | -12.20 | 251.43 | -1.970 | 0.089 |
SBP | -0.72 | 4.82 | -0.330 | 0.741 | -3.33 | 4.48 | -1.190 | 0.235 |
DBP | -0.37 | 2.22 | -0.193 | 0.847 | 1.15 | 3.01 | 0.489 | 0.422 |
心率 | -5.06 | 2.81 | -1.390 | 0.165 | -6.69 | 2.10 | -2.810 | 0.005 |
PEF | -4.26 | 14.48 | -0.090 | 0.927 | -8.48 | 8.99 | -0.704 | 0.482 |
FEV1 | 0.31 | 0.09 | 0.370 | 0.780 | 0.43 | 0.67 | 0.062 | 0.950 |
FVC | 4.83 | 0.16 | 0.744 | 0.457 | 2.76 | 0.08 | 0.410 | 0.682 |
FeNO | -17.34 | 2.83 | -1.220 | 0.223 | -8.84 | 4.70 | -0.240 | 0.809 |
ROS | -0.08 | 0.56 | 0.383 | 0.702 | -4.36 | 0.37 | -1.362 | 0.173 |
GSH | -0.10 | 5.78 | 0.652 | 0.514 | 8.97 | 4.53 | 1.482 | 0.138 |
健康指标 | 改变百分比(%) | SE | t值 | P值 |
---|---|---|---|---|
CRP | 0.18 | 3.438 | 1.067 | 0.314 |
纤维蛋白原 | 0.51 | 1.326 | 3.633 | <0.001 |
P选择蛋白 | 0.11 | 3.546 | 1.426 | 0.184 |
MCP-1 | 0.48 | 0.243 | 4.380 | <0.001 |
IL-1β | 0.10 | 0.043 | 1.194 | 0.230 |
IL-6 | 0.15 | 0.022 | 1.356 | 0.173 |
TNF-α | 0.07 | 0.626 | 0.368 | 0.763 |
MPO | 0.56 | 0.089 | 4.387 | <0.001 |
sCD40L | 0.03 | 1.177 | 0.246 | 0.860 |
PAI-1 | 0.49 | 0.705 | 4.011 | <0.001 |
t-PA | 0.43 | 0.176 | 4.658 | <0.001 |
D-二聚体 | 0.31 | 4.907 | 2.319 | 0.028 |
SBP | 0.03 | 0.100 | 0.497 | 0.708 |
DBP | -0.01 | 0.059 | -0.022 | 0.917 |
心率 | 0.20 | 0.055 | 2.820 | 0.009 |
PEF | 0.21 | 0.280 | 0.489 | 0.625 |
FEV1 | 0.01 | 0.002 | -0.169 | 0.866 |
FVC | -0.10 | 0.003 | -0.732 | 0.464 |
FeNO | 0.41 | 0.079 | 0.788 | 0.431 |
ROS | 0.03 | 0.010 | 0.371 | 0.710 |
GSH | -0.18 | 0.102 | -1.380 | 0.168 |
Table 4 Changes in health indexes of the elderly for every 1 μg/m3 increase in indoor PM2.5 concentration
健康指标 | 改变百分比(%) | SE | t值 | P值 |
---|---|---|---|---|
CRP | 0.18 | 3.438 | 1.067 | 0.314 |
纤维蛋白原 | 0.51 | 1.326 | 3.633 | <0.001 |
P选择蛋白 | 0.11 | 3.546 | 1.426 | 0.184 |
MCP-1 | 0.48 | 0.243 | 4.380 | <0.001 |
IL-1β | 0.10 | 0.043 | 1.194 | 0.230 |
IL-6 | 0.15 | 0.022 | 1.356 | 0.173 |
TNF-α | 0.07 | 0.626 | 0.368 | 0.763 |
MPO | 0.56 | 0.089 | 4.387 | <0.001 |
sCD40L | 0.03 | 1.177 | 0.246 | 0.860 |
PAI-1 | 0.49 | 0.705 | 4.011 | <0.001 |
t-PA | 0.43 | 0.176 | 4.658 | <0.001 |
D-二聚体 | 0.31 | 4.907 | 2.319 | 0.028 |
SBP | 0.03 | 0.100 | 0.497 | 0.708 |
DBP | -0.01 | 0.059 | -0.022 | 0.917 |
心率 | 0.20 | 0.055 | 2.820 | 0.009 |
PEF | 0.21 | 0.280 | 0.489 | 0.625 |
FEV1 | 0.01 | 0.002 | -0.169 | 0.866 |
FVC | -0.10 | 0.003 | -0.732 | 0.464 |
FeNO | 0.41 | 0.079 | 0.788 | 0.431 |
ROS | 0.03 | 0.010 | 0.371 | 0.710 |
GSH | -0.18 | 0.102 | -1.380 | 0.168 |
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