关键词: 胎儿水肿, 疾病管理, 诊断, 治疗, 指南

Abstract: Fetal hydrops is a rather challenging clinical problem.In 2018，the Society of Obstetricians and Gynaecologists of Canada（SOGC） published a clinical practice guideline named No. 363—Investigation and Management of Non-immune Fetal Hydrops（hereinafter referred to as 2018 version guideline）.Compared with the Society for Maternal-Fetal Medicine（SMFM） clinical guideline #7：nonimmune hydrops fetalis　issued in 2014，the 2018 version guideline puts forward some new recommendations on the management of non-immune fetal hydrops on the basis of summarizing the major evidences provided by recent studies.The 2018 version guideline emphasizes the great significance of timely referral for fetal hydrops and suggests that all patients with fetal hydrops should be referred promptly to a tertiary care centre for evaluation，because rapid and timely diagnosis and treatment can significantly improve the prognosis of fetal hydrops caused by fetal anemia，arrhythmia and other factors.Moreover，it suggests that the array CGH（microarray） molecular testing and Doppler measurement of the middle cerebral artery peak systolic velocity should be performed in all hydropic fetuses in order to identify the causes of this disease.Autopsy is strongly recommended for all cases of fetal or neonatal death for which no diagnosis is reached prenatally.Furthermore，non-immune fetal hydrops associated with metabolic disorders are detailed.This guideline is the only one concerning non-immune fetal hydrops published in these 4 years，demonstrating great significance of guidance in clinical practice.

Key words: Hydrops fetalis, Disease management, Diagnosis, Therapy, Guidebooks