关键词: 胎膜早破, 羊水, 诊断技术, 妇产科

Abstract: Objective　To evaluate the clinical feasibility of rapid diagnosis of premature rupture of membranes（PROM） using amniotic fluid monitoring pad（pad method）．Methods　 We enrolled 90 pregnant women who received treatment in Department of Obstetrics and Gynecology，Jiangxi Provincial People's Hospital during June to December 2016 and divided them into group A（confirmed PROM，n=30），group B（suspected PROM，n=30） and group C（intact fetal membranes，n=30） based on the clinical manifestations and results of speculum examination.Pad method，amniotic fluid crystallization test（crystallization test），and pH determination using pH paper（pH method），and human IGFBP-1 ELISA kit（IGFBP-1 method） were all used to diagnose PROM in all cases.The sensitivity，specificity，Youden index，positive and negative predictive values of the four methods were analyzed comparatively.Results　Concretely，the sensitivity，specificity，Youden index，positive and negative predictive values of the pad method were all higher compared with both the crystallization test and pH method（P<0.05）．Conclusion　Pad method is feasible for clinical rapid diagnosis of PROM because it is simple to use（even can be used at home），owns good specificity and sensitivity，and is inexpensive.

Key words: Fetal membranes, premature rupture；Amniotic fluid；Diagnostic techniques, obstetrical and gynecological