Overweight and obesity constitute a significant global public health challenge, impacting individuals across diverse age groups and socioeconomic strata. In 2025, the UK National Institute for Health and Care Excellence (NICE) issued the guideline Overweight and Obesity Management (NG246), which aims to establish an evidence-based therapeutic framework for healthcare practitioners. The NICE guideline underscores the critical role of lifestyle interventions, encompassing behavioral, dietary, and physical activity modalities, and advocates for individualized treatment plans to address the heterogeneous needs of the population. The key updates in this guideline are: (1) Simplifying and optimizing diagnostic tools by recommending differentiated body mass index thresholds for various ethnic groups and strongly endorsing the waist-to-height ratio as the principal assessment tool for central obesity; (2) Elevating the priority of behavioral interventions in weight management, recommending them as the first-line core strategy; (3) Providing more precise, evidence-based recommendations for dietary and physical activity interventions and broadening the implementation settings for weight management. This article aims to interpret the lifestyle intervention component of the NICE guideline and integrate its core principles with the specific context of China, exploring how to effectively apply these updated intervention strategies in the management of overweight and obesity in conjunction with China's domestic guidelines, thereby enhancing the management system and improving the quality of life and health outcomes of affected individuals.