关键词: 乳腺肿瘤, 超声检查, 受体,雌激素, 孕激素类, 分子生物学指标

Abstract: BackgroundThe treatment and prognosis of breast cancer has close correlation with the expression of molecular biological markers.Objective　To investigate the correlation between the direct ultrasonic signs of breast infiltrating ductal carcinoma and the expression of estrogen receptor（ER） and progestrone receptor（PR）.Methods　A retrospective analysis was made on the clinical data of 109 patients with breast infiltrating ductal carcinoma who accorded with inclusion criteria and received the first diagnosis and underwent operation in the Affiliated Tumor Hospital of Xinjiang Medical University from December 2014 to April 2015.General data,immunohistochemical results（expression of ER and PR）,and ultrasound examination results（number,sites,size,stages of nidi and spicule signs,lobulated sign,internal microcalcification,posterior acoustic attenuation,aspect ratio,and Adler grade internal blood flow） were collected.Results　The number of patients with ER（+）,PR（+）,ER（-） and PR（-） was 75（68.8%）,67（61.5%）,34（31.2%） and 42（38.5%） respectively.There were 93 patients who had one nidus and 16 patients who had multiple nidi（the number of nidi ≥2）;48 patients had nidi on the right breast,and 61 patients had nidi on the left breast;the number of patients who had nidi in the out upper quadrant,the inner upper quadrant,the out lower quadrant,the inner lower quadrant was 51,27,16 and 15 respectively;the maximum diameter of nidus was 0.9-8.0 cm,and the average maximum diameter of nidus was（2.8±1.4） cm;the number of patients in T1,T2,T3 and T4 phrase was 28,62,19 and 0.Patients with ER（-）+PR（-） and patients without ER（-）+PR（-） were significantly different in the maximum diameter of nidus（P<0.05）.The direct ultrasonic signs of breast cancer showed that there were 90（82.6%）patients with Adler gradeⅡ-Ⅲ of internal blood flow,58（53.2%） patients who had lobulated sign,58（53.2%） patients who had internal microcalcification,49（45.0%）patients who had spicule signs,49（45.0%） patients who had posterior acoustic attenuation,and 41（37.6%） patients who had aspect ratio≥0.71.Spicule signs,lobulated sign,internal microcalcification and posterior acoustic attenuation had correlation with the expression of ER and PR（P<0.05）;aspect ratio and Adler grade of internal blood flow had mutual dependence from the expression of ER and PR（P>0.05）.Conclusion　Direct ultrasonic signs of breast infiltrating ductal carcinoma has correlation with the expression of ER and PR,and ultrasound can make pre-treatment assessment and prognostic evaluation of breast carcinoma.

Key words: Breast neoplasms, Ultrasonography, Receptors,estrogen, Progestins, Molecular biological markers