关键词: 胃肿瘤, 幽门螺杆菌, 菌株特异性, 地理性差异

Abstract: Gastric cancer is one of the most common malignancies，whose incidence ranks the second among all cancers in China.Many factors participate in the development of gastric cancer，of them，Helicobacter pylori is regarded as the most important carcinogen by WHO.We reviewed the recent studies concerning gastric cancer and Helicobacter pylori strain specificity，in particular，examined the internal relationship of gastric cancer with several Helicobacter pylori proteins（CagA，VacA，outer membrane protein，dupA） based on analyzing in vitro studies and animal model studies.Our findings suggest that the specificity of Helicobacter pylori strains in different regions may lead to the geographical differences in the incidence of gastric cancer.

Key words: Stomach neoplasms, Helicobacter pylori, Strain specificity, Geographical difference