关键词: 高血压, 培哚普利, 内皮, 血管, 血压变异性

Abstract: Objective　To investigate the effects of different doses of perindopril on vascular endothelial function and blood pressure variability（BPV）of patients with essential hypertension.Methods　158 patients with mild and moderate essential hypertension admitted in the People’s Hospital of Zhengzhou University from September 2013 to February 2015 were randomly divided into group A（n=78）or B（n=80）.4 mg/d and 8 mg/d perindopril were given to patients in group A and B respectively.Both groups received continuous treatment for 12 weeks.Fasting plasma glucose（FPG），triacylglycerol（TG），total cholesterol（TC），high density lipoprotein cholesterol（HDL-C），low density lipoprotein cholesterol（LDL-C），uric acid（UA） of the two groups before treatment were recorded；24 h systolic blood pressure（24 hSBP），24 h diastolic blood pressure（24 hDBP），systolic blood pressure variability（SBPV），diastolic blood pressure variability（DBPV）of the two groups before treatment and at the 12th week of treatment were observed；RHI，mAlb，hypersensitivity C reactive protein（hs-CRP），creatinine（Cr）and cystatin C（Cys-C）of the two groups before treatment and at 12th week of treatment were recorded.Results　The comparison of gender，age，body mass index，course of disease，disease degree，FPG，TG，TC，HDL-C，LDL-C，UA of patients in the two groups showed that the differences were not statistically significant（P>0.05）.During treatment，one case in group A withdrew voluntarily because of dry cough，two cases in group B withdrew voluntarily because of dizziness and dry cough.24 hSBP，24 hDBP，SBPV，DBPV of both groups at 12th week of treatment were lower than those before treatment（P<0.01）.Change value of 24 hSBP，24 hDBP，SBPV，DBPV of group B were higher than those of group A（P<0.05）.RHI of both groupsat 12th week of treatment was higher and mAlb，hs-CRP，Cr，Cys-C were lower than those before treatment（P<0.05）.Change value of RHI，mAlb，hs-CRP，Cr，Cys-C of group B were higher than those of group A（P<0.05）.Anaphylactic reaction，excessive decrease of blood pressure and first-dose hypotension occurrence and other adverse reactions were not found in both groups.Results　The dose of 8 mg/d perindopril exerts can stably reduce pressure and improve vascular endothelial function better than 4 mg/d perindopril without many adverse reactions and benefit is dose dependent.

Key words: Hypertension, Perindopril, Endothelium, vascular, Blood pressure variability