体育锻炼对抑郁症患者工作记忆干预效果及影响因素的Meta分析

doi:10.12114/j.issn.1007-9572.2025.0258

中国全科医学 ›› 2026, Vol. 29 ›› Issue (36): 5428-5441.DOI: 10.12114/j.issn.1007-9572.2025.0258

• 论著·医学循证 • 上一篇

体育锻炼对抑郁症患者工作记忆干预效果及影响因素的Meta分析

池廖婧, 李娜, 李雅方^*()

330004　江西省南昌市，江西中医药大学人文学院

收稿日期:2025-08-21 修回日期:2026-01-15 出版日期:2026-12-20 发布日期:2026-10-30
通讯作者: 李雅方
作者贡献：
池廖婧负责文章的构思与设计、研究资料的筛选与编码、表格的编辑与论文撰写；李雅方负责论文修订、文章的质量控制及审校，对文章整体负责、监督管理；李娜负责资料收集与整理。
基金资助:
江西中医药大学博士启动基金(2020BSZR013); 江西中医药大学校级课题:中医心理学(2152401508); 首批校级科技创新团队(CXTD22016); 基于中医志意理论的抑郁症亚型识别技术及神经机制研究(20252BAC200556)

Meta-analysis of the Effect of Physical Exercise on Working Memory in Patients with Depression and Its Influencing Factors

CHI Liaojing, LI Na, LI Yafang^*()

School of Humanities, Jiangxi University of Chinese Medicine, Nanchang 330004, China

Received:2025-08-21 Revised:2026-01-15 Published:2026-12-20 Online:2026-10-30
Contact: LI Yafang

摘要/Abstract

摘要： 背景工作记忆缺陷是抑郁症的核心认知特征，而体育锻炼可能通过神经可塑性机制对其进行改善。然而，现有相关元分析结论存在矛盾，且缺乏对干预剂量（如强度、周期）及年龄等关键调节因素的深入探讨。目的系统评价体育锻炼对抑郁症患者工作记忆的干预效果及影响因素，为临床抑郁症患者工作记忆损伤的体育锻炼方案制订提供参考。方法检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、维普网、万方数据知识服务平台等中、英文数据库中与体育锻炼对抑郁症患者工作记忆干预相关的随机对照试验（RCT），检索时限为建库至2024年12月。由研究者独立筛选文献并进行编码，采用PEDro量表对RCT进行质量评价。采用RevMan 5.3和Stata 17软件进行Meta分析。结果纳入有效文献20篇，样本共计1 475例。研究共纳入31个效应量，Meta分析结果显示，体育锻炼对抑郁症患者的工作记忆改善具有显著疗效（SMD=0.18，95%CI=0.03~0.32，P=0.02）。亚组分析结果显示，体育锻炼干预形式、频次、时间均可调节运动改善抑郁症患者工作记忆的效应：八段锦/太极效应量最高（SMD=0.95，95%CI=0.49~1.40，P<0.001）；每周锻炼7次效果最强（SMD=1.31，95%CI=0.84~1.78，P<0.001），每周5次仍存在明显效应（SMD=0.30，95%CI=0.09~0.52，P=0.005）；单次60 min锻炼效应显著（SMD=0.48，95%CI=0.23~0.73，P<0.001）。结论体育锻炼能够有效改善抑郁症患者的工作记忆，干预效果与锻炼形式、锻炼频率和持续时间有关。制订体育锻炼方案时，尽量以太极、八段锦等慢节奏身心运动形式为主。

关键词: 抑郁症, 运动, 工作记忆, Meta分析, 影响因素分析

Abstract:

Background

Working memory impairment is a core cognitive feature of depression. Physical exercise may improve working memory through neuroplastic mechanisms, yet existing meta-analyses have yielded inconsistent conclusions and lack in-depth exploration of key moderators such as intervention dosage and age.

Objective

To systematically evaluate the effects of physical exercise on working memory in patients with depression and provide evidence for developing clinical exercise interventions for working memory impairment.

Methods

Searched PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, and WanFang Data for RCTs on exercise interventions for working memory in depression patients. Search period: database inception to December 2024. Independently screened and coded studies. Assessed RCT quality using the PEDro scale. Conducted meta-analysis with RevMan 5.3 and Stata 17.

Results

Twenty eligible studies (total sample: n=1 475) with 31 effect sizes were included. Physical exercise significantly improved working memory in depressed patients (SMD=0.18, 95%CI=0.03-0.32, P=0.02). Subgroup analyses showed that the form, frequency and duration of physical exercise intervention moderated the effect of exercise on improving working memory in patients with depression: Baduanjin/Tai Chi yielded the highest effect size (SMD=0.95, 95%CI=0.49-1.40, P<0.001); 7 sessions per week had the strongest effect (SMD=1.31, 95%CI=0.84-1.78, P<0.001), and 5 sessions per week still had a significant effect (SMD=0.30, 95%CI=0.09-0.52, P=0.005); a single 60-min exercise session produced a significant effect (SMD=0.48, 95%CI=0.23-0.73, P<0.001).

Conclusion

Physical exercise effectively improves working memory in depression, with efficacy moderated by exercise modality, frequency, and duration. Tai Chi and Baduanjin are recommended as primary mind-body interventions.

Key words: Depression, Exercise, Working memory, Meta-analysis, Root cause analysis

中图分类号:

R 749.41

池廖婧,李娜,李雅方. 体育锻炼对抑郁症患者工作记忆干预效果及影响因素的Meta分析[J]. 中国全科医学, 2026, 29(36): 5428-5441. DOI: 10.12114/j.issn.1007-9572.2025.0258.
CHI Liaojing,LI Na,LI Yafang. Meta-analysis of the Effect of Physical Exercise on Working Memory in Patients with Depression and Its Influencing Factors[J]. Chinese General Practice, 2026, 29(36): 5428-5441. DOI: 10.12114/j.issn.1007-9572.2025.0258.

图/表 10

参考文献 74

[1]	Rock P L, Roiser J P, Riedel W J, et al. Cognitive impairment in depression: a systematic review and meta-analysis[J]. Psychol Med, 2014, 44(10): 2029-2040. DOI: 10.1017/S0033291713002535.
[2]	Hou Y Q, Liu W, He T B, et al. Association between the performance of executive function and the remission of depressive state after clinical treatment in patients with depression[J]. J Affect Disord, 2024, 364: 28-36. DOI: 10.1016/j.jad.2024.07.137.
[3]	Semkovska M, Quinlivan L, O'grady T, et al. Cognitive function following a major depressive episode: a systematic review and meta-analysis[J]. Lancet Psychiatry, 2019, 6(10): 851-861. DOI: 10.1016/S2215-0366(19)30291-3.
[4]	Chen Z T, Dou Z, Xu H, et al. Decomposing working memory in recurrent major depression: impaired encoding and limited maintenance immune-to-encoding constraint[J]. Brain Sci, 2022, 13(1): 38. DOI: 10.3390/brainsci13010038.
[5]	Everaert J, Koster E H. The interplay among attention, interpretation, and memory biases in depression: revisiting the combined cognitive bias hypothesis[M]//AUE T, OKON-SINGER H. Cognitive biases in health and psychiatric disorders: neuropsychological foundations. San Diego: Academic Press, 2020:193-213.
[6]	Lemoult J, Gotlib I H. Depression: a cognitive perspective[J]. Clin Psychol Rev, 2019, 69: 51-66. DOI: 10.1016/j.cpr.2018.06.008.
[7]	Hong C J, Cody D, Zhu Y, et al. Mindfulness intervention improves executive functions of depressed individuals and their neural mechanism[J]. Chin Sci Bull, 2022, 67(16): 1821-1836. DOI: 10.1360/tb-2022-0054.
[8]	Jenkins A C. Rethinking cognitive load: a default-mode network perspective[J]. Trends Cogn Sci, 2019, 23(7): 531-533. DOI: 10.1016/j.tics.2019.04.008.
[9]	Rutherford A V, Mcdougle S D, Joormann J. "Don't [ruminate], be happy": a cognitive perspective linking depression and anhedonia[J]. Clin Psychol Rev, 2023, 101: 102255. DOI: 10.1016/j.cpr.2023.102255.
[10]	Sun F P, Liu Z N, Yang J, et al. Aberrant brain dynamics in major depressive disorder during working memory task[J]. Eur Arch Psychiatry Clin Neurosci, 2025, 275(4): 1141-1150. DOI: 10.1007/s00406-024-01854-4.
[11]	Chen Y T, Van Ede F, Kuo B C. Alpha oscillations track content-specific working memory capacity[J]. J Neurosci, 2022, 42(38): 7285-7293. DOI: 10.1523/JNEUROSCI.2296-21.2022.
[12]	Jopling E, Gotlib I H, Lemoult J. Effects of working memory training on cognitive, affective, and biological responses to stress in major depression: a novel cognitive bias modification protocol[J]. J Affect Disord, 2020, 265: 45-51. DOI: 10.1016/j.jad.2020.01.007.
[13]	Oyovwi M O, Ogenma U T, Onyenweny A. Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions[J]. Mol Biol Rep, 2025, 52(1): 140. DOI: 10.1007/s11033-025-10248-1.
[14]	王少堃, 王世强, 王一杰, 等. 运动对抑郁症的影响及其神经生物学机制研究进展[J]. 中国全科医学, 2022, 25(27): 3443-3451. DOI: 10.12114/j.issn.1007-9572.2022.0273.
[15]	Schwefel M K, Kaufmann C, Gutmann G, et al. Physical fitness is associated with neural activity during working memory performance in major depressive disorder[J]. Neuroimage Clin, 2023, 38: 103401. DOI: 10.1016/j.nicl.2023.103401.
[16]	Hendrikse J, Chye Y, Thompson S, et al. Regular aerobic exercise is positively associated with hippocampal structure and function in young and middle-aged adults[J]. Hippocampus, 2022, 32(3): 137-152. DOI: 10.1002/hipo.23397.
[17]	Oertel-Knöchel V, Mehler P, Thiel C, et al. Effects of aerobic exercise on cognitive performance and individual psychopathology in depressive and schizophrenia patients[J]. Eur Arch Psychiatry Clin Neurosci, 2014, 264(7): 589-604. DOI: 10.1007/s00406-014-0485-9.
[18]	Sun M, Lanctot K, Herrmann N, et al. Exercise for cognitive symptoms in depression: a systematic review of interventional studies[J]. Can J Psychiatry, 2018, 63(2): 115-128. DOI: 10.1177/0706743717738493.
[19]	Brondino N, Rocchetti M, Fusar-Poli L, et al. A systematic review of cognitive effects of exercise in depression[J]. Acta Psychiatr Scand, 2017, 135(4): 285-295. DOI: 10.1111/acps.12690.
[20]	Ren F F, Alderman B L, Wang W G, et al. Effects of exercise training on executive functioning in adults with depression: a systematic review and meta-analysis of randomized controlled trials[J]. Sports Med, 2023, 53(9): 1765-1788. DOI: 10.1007/s40279-023-01869-2.
[21]	Contreras-Osorio F, Ramirez-Campillo R, Cerda-Vega E, et al. Effects of physical exercise on executive function in adults with depression: a systematic review and meta-analysis[J]. Int J Environ Res Public Health, 2022, 19(22): 15270. DOI: 10.3390/ijerph192215270.
[22]	Hu S D, Shi P, Zhang Z Y, et al. Effects of open-skill exercise on executive functions in children and adolescents: a systematic review and meta-analysis[J]. Front Hum Neurosci, 2025, 18: 1495371. DOI: 10.3389/fnhum.2024.1495371.
[23]	Wang C, Dai Y F, Yang Y, et al. Effects of Tai Chi on working memory in older adults: evidence from combined fNIRS and ERP[J]. Front Aging Neurosci, 2023, 15: 1206891. DOI: 10.3389/fnagi.2023.1206891.
[24]	Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement[J]. Int J Surg, 2010, 8(5): 336-341. DOI: 10.1016/j.ijsu.2010.02.007.
[25]	翁鸿, 王颖, 李柄辉, 等. 系统评价与Meta分析的类型及制作步骤[J]. 同济大学学报(医学版), 2019, 40(2): 248-253. DOI: 10.16118/j.1008-0392.2019.02.022.
[26]	Verhagen A P, De Vet H C, De Bie R A, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus[J]. J Clin Epidemiol, 1998, 51(12): 1235-1241. DOI: 10.1016/s0895-4356(98)00131-0.
[27]	符泽娟, 徐明雅, 王天道, 等. 有氧运动疗法联合选择性5-羟色胺再摄取抑制剂对青少年抑郁症患者精神症状缓解效果和社会功能的影响[J]. 临床与病理杂志, 2022, 42(12): 3047-3054. DOI: 10.3978/j.issn.2095-6959.2022.12.028.
[28]	陈倩倩, 许瑞智, 汪晓静, 等. 有氧运动干预抑郁症缓解期患者认知功能的临床随机对照研究[J]. 中华精神科杂志, 2021, 54(1): 25-30. DOI: 10.3760/cma.j.cn113661-20201127-00485.
[29]	郑天生, 张赢斌, 董周浒, 等. 运动疗法对温州市某医院抑郁障碍患者抑郁症状和认知功能的影响[J]. 医学与社会, 2019, 32(3): 107-111. DOI: 10.13723/j.yxysh.2019.03.027.
[30]	Brüchle W, Schwarzer C, Berns C, et al. Physical activity reduces clinical symptoms and restores neuroplasticity in major depression[J]. Front Psychiatry, 2021, 12: 660642. DOI: 10.3389/fpsyt.2021.660642.
[31]	Buscher V, Prochazka D, Bartl H, et al. Effects of physical activity on cognitive performance: a controlled clinical study in depressive patients[J]. Eur Arch Psychiatry Clin Neurosci, 2018, 269(5): 555-563. DOI: 10.1007/s00406-018-0916-0.
[32]	Halappa N G, Thirthalli J, Varambally S, et al. Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and Yoga[J]. Indian J Psychiatry, 2018, 60(1): 32-37. DOI: 10.4103/psychiatry.IndianJPsychiatry_154_17.
[33]	Hoffman B M, Blumenthal J A, Babyak M A, et al. Exercise fails to improve neurocognition in depressed middle-aged and older adults[J]. Med Sci Sports Exerc, 2008, 40(7): 1344-1352. DOI: 10.1249/MSS.0b013e31816b877c.
[34]	Imboden C, Beck J, Gerber M, et al. P.2.b.027 Aerobic exercise as add-on treatment in depressed inpatients improves cognitive domains but has no additional effect on symptom severity[J]. Eur Neuropsychopharmacol, 2016, 26: S395-S396. DOI: 10.1016/S0924-977X(16)31353-0.
[35]	Imboden C, Gerber M, Beck J, et al. Aerobic exercise or stretching as add-on to inpatient treatment of depression: similar antidepressant effects on depressive symptoms and larger effects on working memory for aerobic exercise alone[J]. Journal of Affective Disorders, 2020, 276: 866-876. DOI: 10.1016/j.jad.2020.07.052.
[36]	Khatri P, Blumenthal J A, Babyak M A, et al. Effects of exercise training on cognitive functioning among depressed older men and women[J]. J Aging Phys Act, 2001, 9(1): 43-57.
[37]	Krogh J, Saltin B, Gluud C, et al. The DEMO trial: a randomized, parallel-group, observer-blinded clinical trial of strength versus aerobic versus relaxation training for patients with mild to moderate depression[J]. J Clin Psychiatry, 2009, 70(6): 790-800. DOI: 10.4088/jcp.08m04241.
[38]	Krogh J, Videbech P, Thomsen C, et al. DEMO-II trial. Aerobic exercise versus stretching exercise in patients with major depression-a randomised clinical trial[J]. PLoS One, 2012, 7(10): e48316. DOI: 10.1371/journal.pone.0048316.
[39]	Lavretsky H, Milillo M M, Kilpatrick L, et al. A randomized controlled trial of Tai Chi chih or health education for geriatric depression[J]. Am J Geriatr Psychiatry, 2021, 30(3): 392-403. DOI: 10.1016/j.jagp.2021.07.008.
[40]	Muhammad I, Putra H L, Kusumawardani M K, et al. Comparing the effect of repetitive transcranial magnetic stimulation therapy and aerobic exercise as an add-on therapy on the cognitive function of patients with depression[J]. Surabaya Phys Med Rehabil J, 2023, 5(2): 51-58. DOI: 10.20473/spmrj.v5i2.25367.
[41]	Olson R L, Brush C J, Ehmann P J, et al. A randomized trial of aerobic exercise on cognitive control in major depression[J]. Clin Neurophysiol, 2017, 128(6): 903-913. DOI: 10.1016/j.clinph.2017.01.023.
[42]	Zhang J L, Chen T X. Effect of aerobic exercise on cognitive function and symptoms in patients with depression[J]. Natl Acad Sci Lett, 2017, 42(5): 419-421. DOI: 10.1007/s40009-018-0769-0.
[43]	Zhang L G, Wang D S, Xie C, et al. The effects of Tai Chi on the executive functions and physical fitness in middle-aged adults with depression: a randomized controlled trial[J]. Evid Based Complement Alternat Med, 2022: 1589106. DOI: 10.1155/2022/1589106.
[44]	Neviani F, Belvederi Murri M, Mussi C, et al. Physical exercise for late life depression: effects on cognition and disability[J]. Int Psychogeriatr, 2017, 29(7): 1105-1112. DOI: 10.1017/S1041610217000576.
[45]	李冰. 艾司西酞普兰联合八段锦运动对老年抑郁症患者睡眠及认知功能的影响[J]. 特别健康, 2024(22): 80-81.
[46]	刘聪, 王慧颖, 冀紫阳, 等. 运动疗法对轻中度抑郁症患者抑郁症状和睡眠质量及认知功能改善的效果分析[J]. 中华精神科杂志, 2024, 57(5): 298-304. DOI: 10.3760/cma.j.cn113661-20230923-00092.
[47]	Wager T D, Smith E E. Neuroimaging studies of working memory: a meta-analysis[J]. Cogn Affect Behav Neurosci, 2003, 3(4): 255-274. DOI: 10.3758/cabn.3.4.255.
[48]	Heled E. Forward versus backward recall: Modality testing[J]. Appl Neuropsychol Adult, 2024: 1-7. DOI: 10.1080/23279095.2024.2371422.
[49]	Kane M J, Hambrick D Z, Tuholski S W, et al. The generality of working memory capacity: a latent-variable approach to verbal and visuospatial memory span and reasoning[J]. J Exp Psychol Gen, 2004, 133(2): 189-217. DOI: 10.1037/0096-3445.133.2.189.
[50]	Ren F F, Chen F T, Zhou W S, et al. Effects of exercise training on cognition in adults with depression: a systematic review and three-level meta-analysis[J]. Int J Nurs Stud, 2025, 168: 105083. DOI: 10.1016/j.ijnurstu.2025.105083.
[51]	Ahn J, Kim M. Effects of exercise therapy on global cognitive function and, depression in older adults with mild cognitive impairment: a systematic review and meta-analysis[J]. Arch Gerontol Geriatr, 2023, 106: 104855. DOI: 10.1016/j.archger.2022.104855.
[52]	Hendrikse J, Chye Y, Thompson S, et al. Regular aerobic exercise is positively associated with hippocampal structure and function in young and middle-aged adults[J]. Hippocampus, 2022, 32(3): 137-152. DOI: 10.1002/hipo.23397.
[53]	Caspersen C J, Powell K E, Christenson G M. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research[J]. Public Health Rep, 1985, 100(2): 126-131.
[54]	Yuan S W, Lin L L, Liu L B, et al. A comparison of the acute effects of high intensity interval training and moderate intensity continuous training on working memory and emotional state in adolescent women with subthreshold depression[J]. Front Public Health, 2025, 13: 1505959. DOI: 10.3389/fpubh.2025.1505959.
[55]	Agostino S, Calandretti M, Veglio F, et al. Physical strength levels and short-term memory efficiency in primary school children: a possible match?[J]. J Sports Med Phys Fitness, 2023, 63(12): 1343-1349. DOI: 10.23736/S0022-4707.23.14996-6.
[56]	Kreppke J N, Cody R, Beck J, et al. Cardiorespiratory fitness, perceived fitness and autonomic function in in-patients with different depression severity compared with healthy controls[J]. J Psychiatr Res, 2024, 175: 437-445. DOI: 10.1016/j.jpsychires.2024.05.044.
[57]	Gerber M, Schilling T, Ludyga S, et al. Validity and feasibility of four standardized aerobic fitness tests in patients with depression: a cross-sectional study[J]. J Psychiatr Res, 2025, 181: 116-125. DOI: 10.1016/j.jpsychires.2024.11.019.
[58]	Ramming H, Theuerkauf L, Hoos O, et al. The association between maximal muscle strength, disease severity and psychopharmacotherapy among young to middle-aged inpatients with affective disorders-a prospective pilot study[J]. BMC Psychiatry, 2024, 24(1): 401. DOI: 10.1186/s12888-024-05849-2.
[59]	Guo X, Xu Y, Meng Y, et al. Acute aerobic exercise intensity on working memory and vigilance after nap deprivation: effects of low-intensity deserve attention[J]. Nat Sci Sleep, 2024, 16: 1431-1449. DOI: 10.2147/NSS.S471930.
[60]	Nakamura M, Kawata Y, Hirosawa M, et al. Differential effects of acute exercise on emotional memory in men and women[J]. Front Sports Act Living, 2023, 5: 1062051. DOI: 10.3389/fspor.2023.1062051.
[61]	Greer T L, Grannemann B D, Chansard M, et al. Dose-dependent changes in cognitive function with exercise augmentation for major depression: results from the TREAD study[J]. Eur Neuropsychopharmacol, 2015, 25(2): 248-256. DOI: 10.1016/j.euroneuro.2014.10.001.
[62]	Nokia M S, Lensu S, Ahtiainen J P, et al. Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained[J]. J Physiol, 2016, 594(7): 1855-1873. DOI: 10.1113/JP271552.
[63]	Herold F, Müller P, Gronwald T, et al. Dose-response matters: a perspective on the exercise prescription in exercise-cognition research[J]. Front Psychol, 2019, 10: 2338. DOI: 10.3389/fpsyg.2019.02338.
[64]	王少堃, 王世强, 王一杰, 等. 骨骼肌介导的运动神经保护效应:作用途径和分子机制[J]. 中国体育科技, 2023, 59(4): 58-66. DOI: 10.16470/j.csst.2021152.
[65]	陈敏, 张晓波, 罗玉珍, 等. 运动锻炼改善抑郁症的神经生物学相关机制研究进展[J]. 中国体育科技, 2021, 57(4): 89-97. DOI: 10.16470/j.csst.2020137.
[66]	Li Z H, Peng X, Xiang W, et al. The effect of resistance training on cognitive function in the older adults: a systematic review of randomized clinical trials[J]. Aging Clin Exp Res, 2018, 30(11): 1259-1273. DOI: 10.1007/s40520-018-0998-6.
[67]	Chen Y F, Zuo X Y, Tang Y, et al. The effects of Tai Chi and Baduanjin on breast cancer patients: systematic review and meta-analysis of randomized controlled trials[J]. Front Oncol, 2024, 14: 1434087. DOI: 10.3389/fonc.2024.1434087.
[68]	Feng Y, Liu J, Liu P, et al. Traditional Chinese exercises on depression: a network meta-analysis[J]. Medicine, 2024, 103(13): e37319. DOI: 10.1097/MD.0000000000037319.
[69]	Wang Y, Tian J, Yang Q X. Tai Chi exercise improves working memory capacity and emotion regulation ability[J]. Front Psychol, 2023, 14: 1047544. DOI: 10.3389/fpsyg.2023.1047544.
[70]	Wang C, Dai Y F, Yang Y, et al. Effects of Tai Chi on working memory in older adults: evidence from combined fNIRS and ERP[J]. Front Aging Neurosci, 2023, 15: 1206891. DOI: 10.3389/fnagi.2023.1206891.
[71]	Zhou X C, Wan Y W, Xu Z X, et al. Utilizing fNIRS to investigate the impact of Baduanjin training on attentional function in post-stroke cognitive impairment patients: a study protocol for a randomized controlled trial[J]. BMC Complement Med Ther, 2024, 24(1): 30. DOI: 10.1186/s12906-023-04284-2.
[72]	娄虎, 刘萍. 身体锻炼治疗抑郁症的元-元分析[J]. 天津体育学院学报, 2018, 33(6): 500-507. DOI: 10.13297/j.cnki.issn1005-0000.2018.06.007.
[73]	Von Cederwald B F, Johansson J, Riklund K, et al. White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging[J]. Transl Psychiatry, 2023, 13(1): 28. DOI: 10.1038/s41398-022-02270-9.
[74]	蔡治东, 尹继林, 王宁, 等. 体育锻炼对老年人工作记忆干预效果的meta分析[J]. 中国心理卫生杂志, 2022, 36(2): 140-146. DOI: 10.3969/j.issn.1000-6729.2022.02.009.

第一作者	年份（年）	国家	年龄（岁）		性别（男/女）		干预措施		疗程（周）	结局指标
第一作者	年份（年）	国家	试验组	对照组	试验组	对照组	试验组	对照组	疗程（周）	结局指标
符泽娟^[27]	2022	中国	15.12±1.83	15.29±1.96	21/24	20/25	药物治疗+有氧运动，5次/周，40~50 min，中等到较大强度	药物治疗	8	①
陈倩倩^[28]	2021	中国	30.3±7.5	32.7±6.5	22/41	20/42	药物治疗+有氧运动，3次/周，30~60 min，中等强度	药物治疗	16	①②
郑天生^[29]	2019	中国	35.17±5.93	37.50±9.12	13/17	14/16	常规综合治疗+有氧运动，5次/周，30 min，中等强度	常规综合治疗	4	③④⑤
Brüchle^[30]	2021	德国	33.3±3.06	40.11±3.63	12/11	11/7	认知训练+身体活动，3次/周，60 min，中等强度	认知训练	3	⑥
Buscher^[31]	2018	德国	47.27±6.84	47.47±8.47	6/9	5/10	药物治疗+有氧运动，2~3次/周，30 min，中等强度	药物治疗+艺术治疗	3~4	①
Halappa^[32]	2018	印度	34.6±8.85	32.84±9.14	38/27	5/14	药物治疗+瑜伽，3次/周，60 min，低强度	药物治疗	12	①
Hoffman^[33]	2008	美国	51.9±7.4	51.2±7.8	26/78	11/38	有氧运动，3次/周，45 min，中度至剧烈强度	安慰剂	16	①
Imboden^[34]	2016	瑞士	37.9±13.1		16	17	住院治疗+有氧运动，3次/周，约45 min，中等强度	住院治疗	6	②
Imboden^[35]	2020	瑞士	41.3±9.2	38.3±13.4	12/10	10/10	住院治疗+有氧运动，3次/周，45 min，中等强度	住院治疗+拉伸运动，45 min,3次/周，低强度	6	②
Khatri^[36]	2001	英国	56.73±6.54		42	42	药物治疗+有氧运动，3次/周，30 min，中度至剧烈强度	药物治疗	16	①
Krogh^[37]	2009	丹麦	38.1±9.0	36.7±8.7	12/43	21/34	药物治疗+有氧运动，2次/周，90 min，中度至剧烈强度	药物治疗+放松训练	16	①
Krogh^[38]	2012	丹麦	39.7±11.3	43.4±11.2	16/40	22/37	有氧运动，3次/周，45 min，中度至剧烈强度	拉伸运动，45 min，低强度	12	①
Lavretsky^[39]	2021	美国	69.1±7.0	72.0±7.4	13/23	15/22	药物治疗+太极拳，3次/周，60 min，低强度	药物治疗+健康教育	12	⑦
Muhammad^[40]	2023	印度尼西亚	28.38±11.08	30.00±8.66	0/8	1/8	药物治疗+有氧运动，5次/周，30 min，中等强度	药物治疗	2	⑧
Olson^[41]	2017	美国	21.0±1.9	21.2±2.2	4/11	2/13	有氧运动，3次/周，45 min，中度强度	拉伸运动，30~45 min，低强度	8	①
Zhang^[42]	2017	中国	31.4±7.2	32.2±7.6	22/0	20/0	药物治疗+有氧运动，3 d/周，3 km约30 min，中等强度	药物治疗	8
Zhang^[43]	2022	中国	47.20±6.99	54.16±6.09	3/17	1/18	太极拳，2次/周，90 min，低强度	等待组维持日常行为	12	⑨
Neviani^[44]	2017	意大利	75.0±6.3	75.6±5.6	25/54	10/32	药物治疗+有氧运动，3次/周，60 min，强度渐进至高强度	药物治疗	24	⑧
李冰^[45]	2024	中国	69.60±5.25	71.72±5.44	19/24	17/26	药物治疗+八段锦，约30 min，低强度	药物治疗	12	⑧
刘聪^[46]	2024	中国	39.02±10.35	40.92±11.35	26/25	25/24	常规综合治疗+有氧运动，3次/周以上，30~60 min，中等强度	常规综合治疗	4	⑧

第一作者	年份（年）	国家	年龄（岁）		性别（男/女）		干预措施		疗程（周）	结局指标
第一作者	年份（年）	国家	试验组	对照组	试验组	对照组	试验组	对照组	疗程（周）	结局指标
符泽娟^[27]	2022	中国	15.12±1.83	15.29±1.96	21/24	20/25	药物治疗+有氧运动，5次/周，40~50 min，中等到较大强度	药物治疗	8	①
陈倩倩^[28]	2021	中国	30.3±7.5	32.7±6.5	22/41	20/42	药物治疗+有氧运动，3次/周，30~60 min，中等强度	药物治疗	16	①②
郑天生^[29]	2019	中国	35.17±5.93	37.50±9.12	13/17	14/16	常规综合治疗+有氧运动，5次/周，30 min，中等强度	常规综合治疗	4	③④⑤
Brüchle^[30]	2021	德国	33.3±3.06	40.11±3.63	12/11	11/7	认知训练+身体活动，3次/周，60 min，中等强度	认知训练	3	⑥
Buscher^[31]	2018	德国	47.27±6.84	47.47±8.47	6/9	5/10	药物治疗+有氧运动，2~3次/周，30 min，中等强度	药物治疗+艺术治疗	3~4	①
Halappa^[32]	2018	印度	34.6±8.85	32.84±9.14	38/27	5/14	药物治疗+瑜伽，3次/周，60 min，低强度	药物治疗	12	①
Hoffman^[33]	2008	美国	51.9±7.4	51.2±7.8	26/78	11/38	有氧运动，3次/周，45 min，中度至剧烈强度	安慰剂	16	①
Imboden^[34]	2016	瑞士	37.9±13.1		16	17	住院治疗+有氧运动，3次/周，约45 min，中等强度	住院治疗	6	②
Imboden^[35]	2020	瑞士	41.3±9.2	38.3±13.4	12/10	10/10	住院治疗+有氧运动，3次/周，45 min，中等强度	住院治疗+拉伸运动，45 min,3次/周，低强度	6	②
Khatri^[36]	2001	英国	56.73±6.54		42	42	药物治疗+有氧运动，3次/周，30 min，中度至剧烈强度	药物治疗	16	①
Krogh^[37]	2009	丹麦	38.1±9.0	36.7±8.7	12/43	21/34	药物治疗+有氧运动，2次/周，90 min，中度至剧烈强度	药物治疗+放松训练	16	①
Krogh^[38]	2012	丹麦	39.7±11.3	43.4±11.2	16/40	22/37	有氧运动，3次/周，45 min，中度至剧烈强度	拉伸运动，45 min，低强度	12	①
Lavretsky^[39]	2021	美国	69.1±7.0	72.0±7.4	13/23	15/22	药物治疗+太极拳，3次/周，60 min，低强度	药物治疗+健康教育	12	⑦
Muhammad^[40]	2023	印度尼西亚	28.38±11.08	30.00±8.66	0/8	1/8	药物治疗+有氧运动，5次/周，30 min，中等强度	药物治疗	2	⑧
Olson^[41]	2017	美国	21.0±1.9	21.2±2.2	4/11	2/13	有氧运动，3次/周，45 min，中度强度	拉伸运动，30~45 min，低强度	8	①
Zhang^[42]	2017	中国	31.4±7.2	32.2±7.6	22/0	20/0	药物治疗+有氧运动，3 d/周，3 km约30 min，中等强度	药物治疗	8
Zhang^[43]	2022	中国	47.20±6.99	54.16±6.09	3/17	1/18	太极拳，2次/周，90 min，低强度	等待组维持日常行为	12	⑨
Neviani^[44]	2017	意大利	75.0±6.3	75.6±5.6	25/54	10/32	药物治疗+有氧运动，3次/周，60 min，强度渐进至高强度	药物治疗	24	⑧
李冰^[45]	2024	中国	69.60±5.25	71.72±5.44	19/24	17/26	药物治疗+八段锦，约30 min，低强度	药物治疗	12	⑧
刘聪^[46]	2024	中国	39.02±10.35	40.92±11.35	26/25	25/24	常规综合治疗+有氧运动，3次/周以上，30~60 min，中等强度	常规综合治疗	4	⑧

体育锻炼对抑郁症患者工作记忆干预效果及影响因素的Meta分析

Meta-analysis of the Effect of Physical Exercise on Working Memory in Patients with Depression and Its Influencing Factors

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