关键词: 炎症性肠病, 双靶治疗, 联合治疗, 生物制剂

Abstract: Inflammatory bowel disease (IBD) is a persistent and recurrent inflammatory condition primarily impacting the intestines. A subset of patients may experience extra-intestinal manifestations, characterized by a significant incidence of intestinal disability and a chronic propensity for recurrence. The limited success rate of biological agents underscores the constraints of the current single-targeted therapeutic approach. Historical evidence of the advantages associated with established combination therapies has motivated researchers to investigate dual-targeted therapeutic strategies involving diverse biological agents. This article provides a comprehensive review of the efficacy, safety, and appropriateness of drug combination therapy strategies based on biologics, while also exploring novel methodologies for the treatment of IBD.

Key words: Inflammatory bowel disease, Dual target therapy, Combination therapy, Biologic agents