脂质代谢异常与抑郁症发展的关联及机制研究进展

doi:10.12114/j.issn.1007-9572.2024.0233

中国全科医学 ›› 2025, Vol. 28 ›› Issue (20): 2562-2569.DOI: 10.12114/j.issn.1007-9572.2024.0233

脂质代谢异常与抑郁症发展的关联及机制研究进展

李欣悦¹, 吴民民¹, 朱路文²^,³^,^*()

1．150040　黑龙江省哈尔滨市，黑龙江中医药大学
2．150001　黑龙江省哈尔滨市，黑龙江中医药大学附属第二医院康复中心
3．150000　黑龙江省哈尔滨市，黑龙江省脑功能与神经康复重点实验室

收稿日期:2024-05-16 修回日期:2024-07-18 出版日期:2025-07-15 发布日期:2025-05-28
通讯作者: 朱路文
作者贡献：
李欣悦负责文章的构思与设计、论文撰写；吴民民负责论文修订、文章的质量控制；朱路文负责资金支持、项目管理、监督管理。
基金资助:
国家自然科学基金资助项目(82174477); 黑龙江省重点研发项目(2022ZX06C24)

Exploration of the Association and Mechanism between Abnormal Lipid Metabolism and Depressive Development

LI Xinyue¹, WU Minmin¹, ZHU Luwen²^,³^,^*()

1. Heilongjiang University of Chinese Medicine, Harbin 150040, China
2. Rehabilitation Center, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, China
3. Heilongjiang Provincial Key Laboratory of Brain Function and Neurorehabilitation, Harbin 150000, China

Received:2024-05-16 Revised:2024-07-18 Published:2025-07-15 Online:2025-05-28
Contact: ZHU Luwen

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摘要/Abstract

摘要： 脂质代谢是人体关键的生理过程，其紊乱与抑郁症的发生和发展密切联系。尽管如此，目前对这些联系的系统性整理尚不充分。本文综合探讨了抑郁症患者的脂质代谢变化，并详细阐述了脂质代谢紊乱与抑郁症共病关系的疾病，如超重、肥胖以及代谢综合征。另外，本文总结了5个脂质代谢异常与抑郁症发展相关的内在机制：α-突触核蛋白基因（SNCA基因）的过表达和α-突触核蛋白（α-Syn）的异常积聚、铁死亡、肠道菌群失调、线粒体质量控制系统障碍以及慢性应激。最后，本文提出了未来研究方向，为抑郁症的早期诊断与治疗提供了新的视角和研究基础。

关键词: 抑郁症, 脂类代谢, 机制, α-突触核蛋白, 多不饱和脂肪酸

Abstract:

Lipid metabolism is a key physiological process in the human body, and its disruption is closely omected with the onset and development of depression. Nevertheless, a systematic collation of these associations is currently inadequate. This article comprehensively explored the changes in lipid metabolism in patients with depression and elaborates on disorders in which disorders of lipid metabolism were co-morbidly associated with depression, such as overweight, obesity and metabolic syndrome. In addition, the article summarised five intrinsic mechanisms by which abnormalities in lipid metabolism were associated with the development of depression: overexpression of SNCA genes and abnormal accumulation of α-Syn, iron death, dysbiosis of gut microbiota, impairment of mitochondrial quality control systems, and chronic stress. Finally, this article suggested future research directions aimed at providing a new perspective and research basis for the early diagnosis and treatment of depression.

Key words: Depression, Lipid metabolism, Mechanism, Alpha-synuclein, Polyunsaturated fatty acids

中图分类号:

R 749.41 R 349.11

李欣悦,吴民民,朱路文. 脂质代谢异常与抑郁症发展的关联及机制研究进展[J]. 中国全科医学, 2025, 28(20): 2562-2569. DOI: 10.12114/j.issn.1007-9572.2024.0233.
LI Xinyue,WU Minmin,ZHU Luwen. Exploration of the Association and Mechanism between Abnormal Lipid Metabolism and Depressive Development[J]. Chinese General Practice, 2025, 28(20): 2562-2569. DOI: 10.12114/j.issn.1007-9572.2024.0233.

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脂质代谢异常与抑郁症发展的关联及机制研究进展

Exploration of the Association and Mechanism between Abnormal Lipid Metabolism and Depressive Development

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