The role of a general practitioner is to serve as the gatekeeper of community health, maintaining long-term doctor-patient relationships and having a comprehensive and continuous understanding of the health status of residents in their jurisdiction. Therefore, general practitioners not only need to address common health issues but also require the ability to identify and manage uncommon diseases. In the case of uncommon diseases, general practitioners face two challenges. Firstly, the symptoms of some unusual diseases are often non-specific, and if there are underlying diseases, they are easily missed in the community. Secondly, even when patients return to the community after receiving treatment at a higher-level hospital, general practitioners may not have enough knowledge about certain diseases and lack the capacity for comprehensive management. As general practitioners, we need to assess patients comprehensively on multiple dimensions, including biological, psychological, social, and familial aspects, to provide more holistic care. This article describes a rare case of primary central nervous system lymphoma. Through the coordinated efforts of multiple departments under the leadership of general medicine, including surgery, postoperative rehabilitation, pain management, and nutritional assessment, the patient gradually improved. After formulating home care and follow-up treatment strategies, the patient was discharged. The article shares the experience of general medicine in managing uncommon diseases through a integrated general-specialty model approach, aiming to enhance the comprehensive management capabilities of general practitioners.