关键词: 前列腺炎, 体质, 中医病因, 体征和症状, 影响因素分析

Abstract: Background　The risk factors for the degree of clinical symptoms of chronic prostatitis （CP） are unclear. TCM constitution has been found to be strongly associated with the development，progression，outcome and prognosis of many diseases，but whether it also affects the development of CP is unknown. Objective　To investigate the distribution of TCM constitution and associated factors of the severity of clinical symptoms in CP patients. Methods　Convenience sampling was used to select 357 first-visit patients with CP from Andrology Clinic，Ningbo Municipal Hospital of TCM from October 2018 to December 2019. They were invited to attend a survey using two self-administered questionnaires，the TCM Constitution Classification and Determination Table for assessing TCM constitution，and Chinese version of NIH-CPSI for evaluating the severity of CP clinical symptoms. The questionnaires were returned immediately after being completed. Multivariate Logistic regression analysis was used to explore the factors associated with the severity of CP clinical symptoms. Results　In all，357 cases（100.0%）who returned responsive questionnaires were included for final analysis. The distribution of TCM constitution was as follows：66 （18.5%） with damp-heat constitution，65（18.2%） with qi-stagnation constitution，44（12.3%） with phlegm-dampness constitution，41（11.5%） with qi-deficiency constitution，37 （10.4%） with balanced constitution，37（10.4%） with yang-deficiency constitution，35 （9.8%） with yin-deficiency constitution，26（7.3%） with blood stasis constitution，and 6（1.6%） with special constitution. The severity of clinical symptoms：142 were mild （39.8%，Chinese version of NIH-CPSI score of 4 to 14），199 were moderate（55.7%，Chinese version of NIH-CPSI score of 15 to 29），and 16 were severe（4.5%，Chinese version of NIH-CPSI score of 30 to 43）. The severity of clinical symptoms differed significantly by monthly income，work stress，sexual satisfaction，sleep time，number of hours of cycling per week，and TCM constitution（P<0.05）. Multivariate Logistic regression analysis showed that monthly income〔<10 000 yuan：OR=0.629，95%CI（0.503，0.785）〕，sleep time 〔OR=0.686，95%CI（0.484，0.971）〕 and TCM constitution 〔damp-heat constitution：OR=3.177，95%CI（1.310，7.702）；qi-stagnation constitution：OR=4.902，95%CI（1.897，12.666）〕 were associated with the severity of clinical symptoms of CP（P<0.05）. Conclusion　Damp-heat constitution and qi-stagnation constitution were the two most common abnormal TCM constitution in CP patients. Low monthly income，insufficient sleep，qi-stagnation constitution and damp-heat constitution were risk factors for the exacerbation of clinical symptoms.

Key words: Prostatitis, Body constitution, Etiological factors （TCM）, Signs and symptoms, Root cause analysis