关键词: 更年期, 高血压, 逍遥散, 治疗结果, 药理作用

Abstract: Background　Hypertension is one of the common complications of menopause in women.Changes in hormone levels affect blood pressure control，and conventional western medicine treatment is not ideal.Therefore，the treatment of senile hypertension with traditional Chinese medicine has gradually become a research hotspot.Objective　To investigate the pharmacological analysis and clinical curative effect of Xiaoyao Powders in the treatment of menopausal hypertension.Methods　A total of 90 postmenopausal patients with hypertension who were admitted to Beijing Anzhen Hospital，Capital Medical University from April 2015 to April 2016 were selected.The patients were divided into two groups according to the numerical randomization method，each with 45 cases.In the control group，patients were treated by oral western medicine according to the disease stage，and patients in the observation group were added with Xiaoyao Powders.With 4 weeks as a course of treatment，both groups were treated for 2 consecutive courses.The efficacy of treatment，blood pressure variability（BPV），TCM symptom score，C-reactive protein（CRP），homocysteine（Hcy） and angiotensin Ⅱ（Ang Ⅱ） levels were compared between the two groups before and after the treatment.Results　The effective rate of treatment in the observation group was higher than that in the control group〔95.6%（43/45） vs 80.0%（36/45），P<0.05〕.There were no significant differences in BPV of 24 h systolic blood pressure（SBP），daytime SBP，nighttime SBP，24 h diastolic blood pressure（DBP），daytime DBP，and nighttime DBP between the two groups before treatment（P>0.05）．The above indicators of the observation group were lower than those of the control group after treatment（P<0.05）．There was no significant difference in the scores of TCM syndrome between the two groups before treatment（P>0.05）．After the treatment，the scores of TCM syndrome in the observation group were lower than those in the control group（P<0.05）．There were no significant differences in CRP，Hcy and Ang Ⅱ levels between the two groups before treatment（P>0.05）．The levels of CRP，Hcy and Ang Ⅱ in the observation group were lower than those in the control group after the treatment（P<0.05）．Conclusion　Xiaoyao Powders can have a significant antihypertensive effect in the treatment of menopausal hypertension.It can improve the patient's psychological status and symptoms.Its pharmacological effect canreduce inflammation and destroy angiotensin-mediated effects to decrease blood pressure through suppressing hyperactivity of liver，benefiting liver and kidney，clearing away heat and detoxicating.

Key words: Climacteric, Hypertension, Xiaoyao Powders, Treatment outcome, Pharmacologic actions