关键词: 糖尿病, 2型；空腹胰岛素；外源性胰岛素；非酒精性脂肪肝病；体质指数；血红蛋白, 糖基化

Abstract: Objective　To investigate the effect of exogenous insulin （EIns） on fasting insulin （FIns） levels in patients with type 2 diabetes mellitus （T2DM）．Methods　We selected 447 patients with T2DM hospitalized in Department of Endocrinology，Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from 2016 to 2017.We collected their demographic and laboratory test results.Based on the level of FIns，we divided them into three groups with equal sample size，low FIns group（FIns≤8.1 mU/L），medium FIns group（8.1 mU/L<FIns≤12.0 mU/L） and high FIns group（FIns>12.0 mU/L），149 cases in each group.Results　There were significant differences in the rate of initial treatment，use of EIns，prevalence of ketosis，history of NAFLD，history of hypertension，history of hyperuricemia （gout），history of hyperlipidemia，BMI，HbA1c，G120，Gmax，Tmax，Gr，HOMA-β，HOMA-IR，WBC and eosinophil count among three groups（P<0.05）．Ordinal Logistic regression analysis revealed that EIns 〔OR=3.768，95%CI （2.248，6.314）〕，history of NAFLD 〔OR=1.543，95%CI （1.037，2.295）〕，BMI 〔OR=1.223，95%CI （1.145，1.307）〕，HbA1c 〔OR=0.861，95%CI （0.755，0.983）〕 and Tmax〔OR=0.989，95%CI （0.980，0.997）〕 were the associated factors of FIns （P<0.05）．Conclusion　The use of EIns may promote the elevation of FIns levels in T2DM patients.

Key words: Diabetes mellitus, type 2；Fasting insulin；Exogenous insulin；Nonalcoholic fatty liver disease；Body mass index；Hemoglobin A, glycosylated