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           老年隐匿性高血压患者颈动脉内 - 中膜厚度

           及心外膜脂肪厚度与轻度认知功能障碍的关系研究

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           巩祺芸,邵平乐,惠加谋            *                                                            查看原文


               【摘要】 背景 近些年人口老龄化问题突出,目前国内外学者对于高血压与轻度认知功能障碍(MCI)关系的
           研究较多,但对于老年隐匿性高血压(MH)与 MCI 关系的研究较少。目的 探讨颈动脉内 - 中膜厚度(CIMT)及心
           外膜脂肪厚度(EAT)与老年 MH 患者发生 MCI 的关系,为提早发现老年 MH 患者 MCI 提供理论依据。方法 选取
           2019 年 1 月至 2022 年 2 月于嘉峪关市中医医院门诊及住院部就诊已经确诊为 MH 的老年患者 173 例为 MH 组,另选
           取血压正常老年健康人群 82 例为对照组。两组受试者均行动态血压仪监测和 CIMT、EAT 测量,记录相关指标。采用
           蒙特利尔认知评估量表(MoCA 量表)评估两组受试者的认知功能。采用二元 Logistic 回归分析探究老年 MH 患者发生
           MCI 的影响因素。结果 MH 组年龄、诊室收缩压、诊室舒张压、24 h 动态收缩压、24 h 动态舒张压、24 h 收缩压变
           异系数、24 h 舒张压变异系数、CIMT 及 EAT 均高于对照组(P<0.05),受教育年限短于对照组(P<0.05)。MH 组视
           空间与执行能力、命名、注意、语言、抽象、延迟回忆评分及 MoCA 总分均低于对照组(P<0.05)。相关性分析结果
           显示,老年 MH 患者 MoCA 总分与年龄、24 h 舒张压变异系数、CIMT、EAT 呈负相关(P<0.001)。二元 Logistic 回归
           分析结果显示,CIMT〔OR=48.282,95%CI(10.734,217.168)〕、EAT〔OR=2.124,95%CI(1.057,4.269)〕是老
           年 MH 患者发生 MCI 的影响因素(P<0.05)。结论 MH 患者较健康者年龄增高、受教育年限少、24 h 收缩压变异系
           数增高。CIMT、EAT 增高是老年 MH 患者发生 MCI 的危险因素。
               【关键词】 隐匿性高血压;认知功能障碍;颈动脉内 - 中膜厚度;心外膜脂肪厚度;老年人;MoCA 量表;相关;
           影响因素分析
               【中图分类号】 R 544.1 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2022.0473
               巩祺芸,邵平乐,惠加谋 . 老年隐匿性高血压患者颈动脉内 - 中膜厚度及心外膜脂肪厚度与轻度认知功能障碍的
           关系研究[J]. 中国全科医学,2022,25(33):4139-4144. [www.chinagp.net]
               GONG Q Y,SHAO P L,HUI J M. Relationship of carotid intima-media thickness and epicardial fat thickness with mild
           cognitive impairment in elderly patients with masked hypertension[J]. Chinese General Practice,2022,25(33):4139-
           4144.


           Relationship of Carotid Intima-media Thickness and Epicardial Fat Thickness with Mild Cognitive Impairment in
           Elderly Patients with Masked Hypertension GONG Qiyun,SHAO Pingle,HUI Jiamou *
           Department of Ultrasound Imaging,Municipal Hospital of Traditional Chinese Medicine of Jiayuguan,Jiayuguan 735100,
           China
           *
           Corresponding author:HUI Jiamou,Attending physician;E-mail:jygzyyycsyxk@sina.com
               【Abstract】 Background Population aging has become a prominent problem in recent years. At present,there are
           many studies on hypertension and mild cognitive impairment(MCI),but few studies on the relationship between masked
           hypertension(MH) and MCI in elderly patients. Objective To investigate the relationship of carotid intima-media thickness
           (CIMT) and epicardial fat thickness(EAT) with cognitive dysfunction in elderly patients with MH,to provide a theoretical
           basis for early detection of mild changes in cognitive function in this group. Methods A total of 255 cases were selected from
           Municipal Hospital of Traditional Chinese Medicine of Jiayuguan from January 2019 to February 2022,including 173 elderly
           inpatients and outpatients diagnosed with MH(MH group),and 82 elderly healthy people with normal blood pressure(control
           group). Ambulatory blood pressure monitoring,CIMT and EAT measurement were performed in both groups,and relevant
           indicators were recorded. The Montreal Cognitive Assessment(MoCA) scale was used to assess the cognitive function. Binary
           Logistic regression analysis was used to explore the factors associated with MCI in MH. Results Compared with control group,


               735100 甘肃省嘉峪关市中医医院超声影像科
               *
               通信作者:惠加谋,主治医师;E-mail:jygzyyycsyxk@sina.com
               本文数字出版日期:2022-08-31
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