Page 127 - 中国全科医学2022-29

·3708· http://www.chinagp.net E-mail:zgqkyx@chinagp.net.cn

enrichment of hepatic endoplasmic Reticulum-mitochondria contact Physical exercise and brain mitochondrial fitness：the possible role
leads to mitochondrial dysfunction in obesity［J］. Nat Med，2014， against Alzheimer's disease［J］. Brain Pathol，2016，26（5）：
20（12）：1427-1435. DOI：10.1038/nm.3735. 648-663. DOI：10.1111/bpa.12403.
［48］BORYS J，MACIEJCZYK M，ANTONOWICZ B，et al. Glutathione ［60］GAN Z J，FU T T，KELLY D P，et al. Skeletal muscle mitochondrial
metabolism，mitochondria activity，and nitrosative stress in patients remodeling in exercise and diseases［J］. Cell Res，2018，28（10）：
treated for mandible fractures［J］. J Clin Med，2019，8（1）： 969-980. DOI：10.1038/s41422-018-0078-7.
E127. DOI：10.3390/jcm8010127. ［61］LUCAS S J，COTTER J D，BRASSARD P，et al. High-intensity
［49］FREEMAN L R，ZHANG L，NAIR A，et al. Obesity increases interval exercise and cerebrovascular health：curiosity，cause，and
cerebrocortical reactive oxygen species and impairs brain consequence［J］. J Cereb Blood Flow Metab，2015，35（6）：
function［J］. Free Radic Biol Med，2013，56：226-233. DOI： 902-911. DOI：10.1038/jcbfm.2015.49.
10.1016/j.freeradbiomed.2012.08.577. ［62］TAKIMOTO M，HAMADA T. Acute exercise increases brain region-
［50］MORRISON C D，PISTELL P J，INGRAM D K，et al. High fat specific expression of MCT1，MCT2，MCT4，GLUT1，and COX IV
diet increases hippocampal oxidative stress and cognitive impairment proteins［J］. J Appl Physiol （1985），2014，116（9）：1238-
1250. DOI：10.1152/japplphysiol.01288.2013.
in aged mice：implications for decreased Nrf2 signaling［J］.
［63］GUSDON A M，CALLIO J，DISTEFANO G，et al. Exercise
J Neurochem，2010，114（6）：1581-1589. DOI：10.1111/
increases mitochondrial complex I activity and DRP1 expression in the
j.1471-4159.2010.06865.x.
brains of aged mice［J］. Exp Gerontol，2017，90：1-13. DOI：
［51］MA W W，DING B J，WANG L J，et al. Involvement of nuclear
10.1016/j.exger.2017.01.013.
related factor 2 signaling pathway in the brain of obese rats and
［64］RAI S，CHOWDHURY A，RENIERS R L E P，et al.
obesity-resistant rats induced by high-fat diet［J］. J Med Food，
A pilot study to assess the effect of acute exercise on brain
2016，19（4）：404-409. DOI：10.1089/jmf.2015.3500.
glutathione［J］. Free Radic Res，2018，52（1）：57-69. DOI：
［52］PINTANA H，SRIPETCHWANDEE J，SUPAKUL L，et al. Garlic
10.1080/10715762.2017.1411594.
extract attenuates brain mitochondrial dysfunction and cognitive deficit
［65］FREITAS D A，ROCHA-VIEIRA E，SOARES B A，et al. High
in obese-insulin resistant rats［J］. Appl Physiol Nutr Metab，
intensity interval training modulates hippocampal oxidative stress，
2014，39（12）：1373-1379. DOI：10.1139/apnm-2014-0255.
BDNF and inflammatory mediators in rats［J］. Physiol Behav，
［53］CAMPBELL W W，KRAUS W E，POWELL K E，et al. High-
2018，184：6-11. DOI：10.1016/j.physbeh.2017.10.027.
intensity interval training for cardiometabolic disease prevention［J］.
［66］MELO C S，ROCHA-VIEIRA E，FREITAS D A，et al. A single
Med Sci Sports Exerc，2019，51（6）：1220-1226. DOI：
session of high-intensity interval exercise increases antioxidants
10.1249/MSS.0000000000001934.
defenses in the hippocampus of Wistar rats［J］. Physiol Behav，
［54］DA SILVA M A R，BAPTISTA L C，NEVES R S，et al. The effects
2019，211：112675. DOI：10.1016/j.physbeh.2019.112675.
of concurrent training combining both resistance exercise and high-
［67］FETER N，SPANEVELLO R M，SOARES M S P，et al. How
intensity interval training or moderate-intensity continuous training on
does physical activity and different models of exercise training affect
metabolic syndrome［J］. Front Physiol，2020，11：572. DOI：
oxidative parameters and memory?［J］. Physiol Behav，2019，
10.3389/fphys.2020.00572.
201：42-52. DOI：10.1016/j.physbeh.2018.12.002.
［55］VIANA R B，NAVES J P A，COSWIG V S，et al. Is interval training
［68］LI B X，LIANG F，DING X Y，et al. Interval and continuous
the magic bullet for fat loss? A systematic review and meta-analysis
exercise overcome memory deficits related to β-Amyloid accumulation
comparing moderate-intensity continuous training with high-intensity
through modulating mitochondrial dynamics［J］. Behav Brain Res，
interval training （HIIT）［J］. Br J Sports Med，2019，53（10）：
2019，376：112171. DOI：10.1016/j.bbr.2019.112171.
655-664. DOI：10.1136/bjsports-2018-099928.
［69］HU J Y，CAI M，SHANG Q H，et al. Elevated lactate by high-
［56］WEWEGE M，VAN DEN BERG R，WARD R E，et al. The effects intensity interval training regulates the hippocampal BDNF expression
of high-intensity interval training vs. moderate-intensity continuous and the mitochondrial quality control system［J］. Front Physiol，
training on body composition in overweight and obese adults：a 2021，12：629914. DOI：10.3389/fphys.2021.629914.
systematic review and meta-analysis［J］. Obes Rev，2017，18（6）： ［70］RAEFSKY S M，MATTSON M P. Adaptive responses of neuronal
635-646. DOI：10.1111/obr.12532. mitochondria to bioenergetic challenges：roles in neuroplasticity and
［57］ROBINSON M M，LOWE V J，NAIR K S. Increased brain glucose disease resistance［J］. Free Radic Biol Med，2017，102：203-
uptake after 12 weeks of aerobic high-intensity interval training in 216. DOI：10.1016/j.freeradbiomed.2016.11.045.
young and older adults［J］. J Clin Endocrinol Metab，2018，103（1）： ［71］ZHANG F，ZHANG L，QI Y，et al. Mitochondrial cAMP
221-227. DOI：10.1210/jc.2017-01571. signaling［J］. Cell Mol Life Sci，2016，73（24）：4577-4590.
［58］DRIGNY J，GREMEAUX V，DUPUY O，et al. Effect of interval DOI：10.1007/s00018-016-2282-2.
training on cognitive functioning and cerebral oxygenation in obese ［72］MEYER J N，LEUTHNER T C，LUZ A L. Mitochondrial fusion，
patients：a pilot study［J］. J Rehabil Med，2014，46（10）： fission，and mitochondrial toxicity［J］. Toxicology，2017，391：
1050-1054. DOI：10.2340/16501977-1905. 42-53. DOI：10.1016/j.tox.2017.07.019.
［59］BERNARDO T C，MARQUES-ALEIXO I，BELEZA J，et al. ［73］POPOV L D. Mitochondrial biogenesis：an update［J］. J Cell Mol