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           patients,providing a reference for choosing an appropriate exercise modality for GDM patients. Methods Two hundred and ten
           GDM patients were recruited from the First Affiliated Hospital of Guangxi Medical University and the Second Affiliated Hospital of
           Guangxi Medical University from August 2019 to December 2020. By use of a random number sequence generated in Excel,they
           were equally divided into aerobic training(AT) group(moderate-intensity walking),resistance training(RT) group(lifting
           dumbbell while sitting) and RT+AT group(moderate-intensity walking plus lifting dumbbell while sitting). Metabolic indices
           were measured at baseline,1 and 3 months after the intervention,and at delivery,respectively,including fasting blood glucose
           (FBG),two-hour postprandial blood glucose(2 hPBG),glycosylated hemoglobin(HbA 1c ),body weight,systolic blood
           pressure(SBP) and diastolic blood pressure(DBP). Pregnancy outcomes were also observed. Results AT group,RT group
           and RT+AT group finally completed the test in 65 cases,64 cases and 62 cases. (1)Significant decreases were found in average
           levels of FBG,2 hPBG,SBP,and DBP in all groups at 1 and 3 months post-intervention(P<0.05). The average level of
           HbA 1c  in RT and RT+AT groups showed a successive decrease over the period from baseline to 1,and 3 months post-intervention
           (P<0.05). The average level of DBP also demonstrated a successive decrease in these two groupsover the period from baseline to
           1,and 3 months post-intervention(P<0.05). The average levels of 2 hPBG and HbA 1c  in RT+AT group were lower than those
           of other two groups at 3 months post-intervention(P<0.05). (2)The average gestational age,incidence of preterm delivery
           and pregnancy-induced hypertension,number of insulin users,and average weight gain in late pregnancy showed no significant
           intergroup differences(P>0.05). The incidence of cesarean delivery in RT+AT group was lower than that of other two groups,
           the average amount of postpartum bleeding in RT and RT+AT groups were lower than that of AT group(P<0.05). (3)The
           average neonatal birth weight and length,and 1-minute Apgar score had no significant intergroup differences(P>0.05). The
           incidence of macrosomia varied significantly accross the groups(P<0.05). In particular,RT+AT group had a lower incidence
           of macrosomia than AT group(P<0.05). Conclusion All of AT,RT and RT plus AT could improve the metabolic indices
           of GDM patients,but RT plus AT may be more effective. Furthermore,RT plus AT may also be more effective in improving
           maternal and infant outcomes of GDM patients.
               【Key words】 Diabetes,gestational;Aerobic exercise;Resistance exercise;Combined resistance and aerobic
           exercise;Metabolism;Pregnancy outcome


               妊娠期糖尿病(GDM)是指妊娠期间首次发生或                          准 [4] ;(2)年龄 18~50 岁;(3)孕周 24~26 周;(4)
           发现的不同程度的葡萄糖耐受不良               [1] 。2019 年国际糖        单胎;(5)肌力Ⅳ级及以上,无运动和沟通障碍;(6)
           尿病联盟(IDF)      [2] 公布的地图数据显示,2019 年有                知情同意,自愿加入。排除标准:(1)糖尿病合并妊娠;
           2 040 万孕妇(15.8%)处于妊娠期高血糖状态,其中                       (2)严重的心、肝、肺、肾损伤;(3)糖尿病所致急、
           83.6% 由 GDM 引起。GDM 对孕妇及胎儿影响较大,如                     慢性并发症,如酮症酸中毒和糖尿病足等;(4)精神
           妊娠期高血压综合征(包括子痫)、剖宫产、巨大儿、                            疾病;(5)妊娠方式为试管婴儿。退出标准:(1)有
           母体和胎儿未来发展为 2 型糖尿病概率增加等                   [1] ,严     早产、胎膜早破倾向;(2)子痫前期;(3)运动期间
           重危害母婴健康。研究报道有氧运动(AT)、抗阻运                            出现酮症酸中毒、高渗性非酮症性昏迷、乳酸性酸中毒、
           动(RT)对 GDM 是有益的运动方式,可增加组织对葡                         急性感染等;(4)依从性差且不能定期来院产前检查;
           萄糖摄取和运输能力,提高胰岛素敏感性,降低患者血                            (5)主动要求退出;(6)运动时间不足 3 个月就发生
           糖,减少不良事件的发生           [3] 。但目前仅有少量系统综               分娩。本研究已通过广西医科大学第一附属医院伦理委
           述或 Meta 分析对不同运动方式干预 GDM 的效果进行                       员会批准,审批编号:2020(KY-E-117)号,患者均
           研究,由于纳入的研究缺乏统一的 GDM 诊断标准、运                          签署知情同意书。
           动方式、强度、时间、频率,从而导致可比性和结果的                            1.2 研究方法
           有效性下降。本研究旨在比较 AT、RT、AT+RT 干预对                       1.2.1 分组及资料收集方法 采用 Excel 产生的随机
           GDM 患者代谢指标及妊娠结局的影响,为 GDM 患者的                        数字序列将患者随机分为 AT 组 70 例、RT 组 70 例、
           运动干预提供理论依据。                                         RT+AT 组 70 例。由于疫情期间患者产检复查率低、运
           1 对象与方法                                             动依从性低、早产等原因导致 AT 组脱落 5 例,RT 组
           1.1 研究对象 选取 2019 年 8 月至 2020 年 12 月于广               脱落 6 例,RT+AT 组脱落 8 例,最终 AT 组 65 例、RT
           西医科大学第一附属医院和广西医科大学第二附属医院                            组 64 例、RT+AT 组 62 例完成试验。通过查阅病例,
           收治的 210 例 GDM 患者为研究对象。纳入标准:(1)                      收集患者一般资料,包括年龄、孕周、胎次、职业、文
           满足 2017 年美国妇产科医师学会推荐的 GDM 诊断标                       化水平。
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