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           间歇性禁食对心血管疾病危险因素影响的研究进展


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           崔艳如 ,岑秋宇 ,魏娟芳 ,王文春 ,张安仁                      3*                                   扫描二维码
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               【摘要】 近年来,我国心血管疾病的患病率和死亡率呈明显上升趋势,心血管疾病已成为危害我国居民健康的
           主要疾病。间歇性禁食(IF)作为一种周期性能量限制的饮食干预方式,已被证明有广泛的健康益处,有助于减轻体
           质量、改善葡萄糖调节、降低血压和血脂水平、抑制炎性反应等,进而延缓心血管疾病的发生与发展。目前,我国学
           者对 IF 在防治心血管疾病中的潜在作用关注不足。本文通过对 IF 对血脂异常、肥胖、糖尿病、高血压等心血管疾病
           危险因素的影响及其机制进行综述,旨在为心血管疾病的防治提供新思路。本研究发现 IF 在心血管疾病防治中具有
           潜在的应用前景,可用于防控心血管疾病发生的危险因素,其介导的代谢益处可能与激发“代谢转换”、增强白色脂
           肪褐变、促进自噬及重塑肠道菌群等有关。
               【关键词】 间歇性禁食;心血管疾病;危险因素;热量限制;综述
               【中图分类号】 R 459.3 R 54 【文献标识码】 A DOI:10.12114/j.issn.1007-9572.2021.00.330
               崔艳如,岑秋宇,魏娟芳,等 . 间歇性禁食对心血管疾病危险因素影响的研究进展[J]. 中国全科医学,2022,25(1):
           127-130. [www.chinagp.net]
               CUI Y R,CEN Q Y,WEI J F,et al. Research progress on the influence of intermittent fasting on cardiovascular disease
           risk factors[J]. Chinese General Practice,2022,25(1):127-130.

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           Research Progress on the Influence of Intermittent Fasting on Cardiovascular Disease Risk Factors CUI Yanru ,CEN
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           Qiuyu ,WEI Juanfang ,WANG Wenchun ,ZHANG Anren 3*
           1.School of Health and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China
           2.Department of Rehabilitation Medicine,the General Hospital of Western Theater Command,Chengdu 610083,China
           3.Department of Rehabilitation Medicine,Shanghai Fourth People's Hospital Affiliated to Tongji University,Shanghai 200434,
           China
           *
           Corresponding author:ZHANG Anren,Chief physician,Doctoral supervisor;E-mail:1518526780@qq.com
               【Abstract】 In recent years,the prevalence and mortality of cardiovascular diseases in China have shown a significant
           upward trend,cardiovascular disease has become a major disease endangering the health of Chinese residents. Intermittent fasting
           (IF)as a cyclical energy restriction dietary intervention has been proven to have a wide range of health benefits,which can
           reduce weight,improve glucose regulation,lower blood pressure and blood lipid levels,inhibit inflammation,so as to delay
           the occurrence and development of cardiovascular disease. Currently,researchers in China have paid insufficient attention to the
           potential role of IF in the prevention and treatment of cardiovascular diseases. This article reviews the effects and mechanisms of IF
           on cardiovascular disease risk factors such as dyslipidemia,obesity,diabetes and hypertension,in order to provide new ideas for
           the prevention and treatment of cardiovascular diseases. It is found that IF has potential application prospects in the prevention and
           treatment of cardiovascular diseases,which can be used to prevent and control the risk factors of cardiovascular disease,the IF-
           mediated metabolic benefits can be related to glucose-ketone body metabolic transformation,browning of white fat,autophagy
           pathway and remodeling of intestinal flora.
               【Key words】 Intermittent fasting;Cardiovascular diseases;Risk factors;Caloric restriction;Review



               心血管疾病是当今世界上严重威胁人类健康的主要疾病                        式的转变,我国心血管疾病的患病率和死亡率呈明显上升趋
           之一。近 20 年来,随着人们生活水平的快速提高和生活方                        势 [1] 。《中国心血管健康和疾病报告 2019》显示,心血管疾
                                                               病死亡占我国城乡居民总死亡原因的首位,农村为 45.91%,
               基金项目:国家自然科学基金面上项目(81973927)                                [2]
               1.610075 四川省成都市,成都中医药大学养生康复学院                   城市为 43.56%   。防治心血管疾病,已刻不容缓。研究显示,
               2.610083 四川省成都市,西部战区总医院康复医学科                    肥胖、高血压、糖尿病、血脂异常是心血管疾病的常见危险
               3.200434 上海市,同济大学附属上海市第四人民医院康复医学科               因素 [2] 。早期识别并有效控制上述危险因素,对于延缓心血
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               通信作者:张安仁,主任医师,博士生导师;                            管疾病的发生、发展至关重要。间歇性禁食(IF),即周期
               E-mail:1518526780@qq.com
               本文数字出版日期:2021-11-10                             性地在一定时间内保持零热量或极低热量摄入,是一种新型
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