Role of Light Therapy in Circadian Rhythm
Sleep-wake Disorders

doi:10.12114/j.issn.1007-9572.2021.01.030

Abstract

Abstract:

Circadian rhythm sleep-wake disorder (CRSWD) affects people's health and well-being.Current treatments mainly include exogenous melatonin therapy and light therapy, among which light therapy plays an important role in the treatment of CRSWDas a non-drug treatment.We conducted a review on recent studies about CRSWD, covering the pathogenesis of CRSWD, principle and efficacy of light therapy in CRSWD, aiming to offer new ideas for clinical treatment of CRSWD.

Key words: Sleep disorders, circadian rhythm, Circadian rhythm, Phototherapy, Review

摘要：

昼夜节律睡眠-觉醒障碍影响着人们的健康和幸福。而目前的治疗主要包括外源性褪黑素治疗和光疗，其中光疗作为非药物治疗方法在昼夜节律睡眠-觉醒障碍的治疗中有着举足轻重的地位。本文将通过分析近年来光疗治疗昼夜节律睡眠-觉醒障碍的文献，对昼夜节律睡眠-觉醒障碍的发病机制、光疗机制以及疗效进行详细阐述，以期在临床上对昼夜节律睡眠-觉醒障碍的治疗提供新的思路。

关键词: 睡眠障碍, 昼夜节律性, 昼夜节律, 光疗法, 综述

CLC Number:

R749.79

CHEN Feng, FAN Mei, XIANG Ting, PAN Jiyang.

Role of Light Therapy in Circadian Rhythm Sleep-wake Disorders [J]. Chinese General Practice, 2022, 25(02): 248-253.

陈凤,樊梅,向婷等. 光疗在昼夜节律睡眠-觉醒障碍中的应用进展[J]. 中国全科医学, 2022, 25(02): 248-253. DOI: 10.12114/j.issn.1007-9572.2021.01.030.

References 75

[1]	LEUFSTADIUS C，ERLANDSSON L K，EKLUND M. Time use and daily activities in people with persistent mental illness[J]. Occup Ther Int，2006，13（3）：123-141. DOI：10.1002/oti.207.
[2]	BENCA R，DUNCAN M J，FRANK E，et al. Biological rhythms，higher brain function，and behavior：Gaps，opportunities，and challenges[J]. Brain Res Rev，2009，62（1）：57-70.
[3]	ERREN T C，LEWIS P. Hypothesis：ubiquitous circadian disruption can cause cancer[J]. Eur J Epidemiol，2019，34（1）：1-4.
[4]	GARAULET M，MARTINEZ-NICOLAS A，RUIZ J R，et al. Fragmentation of daily rhythms associates with obesity and cardiorespiratory fitness in adolescents：the HELENA study[J].Clin Nutr，2017，36（6）：1558-1566.
[5]	MCHILL A W，WRIGHT K P Jr. Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease[J]. Obes Rev，2017，18（）：15-24. DOI：10.1111/obr.12503.
[6]	LI Y，VGONTZAS A N，FERNANDEZ-MENDOZA J，et al. Insomnia with physiological hyperarousal is associated with hypertension[J]. Hypertension，2015，65（3）：644-650.
[7]	XIANG Y T，MA X，CAI Z J，et al. The prevalence of insomnia，its sociodemographic and clinical correlates，and treatment in rural and urban regions of Beijing，China：a general population-based survey[J]. Sleep，2008，31（12）：1655-1662. DOI：10.1093/sleep/31.12.1655.
[8]	BUSCEMI N，VANDERMEER B，HOOTON N，et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction：meta-analysis[J]. BMJ，2006，332（7538）：385-393.
[9]	TERMAN M，TERMAN J S. Light therapy for seasonal and nonseasonal depression：efficacy，protocol，safety，and side effects[J]. CNS Spectr，2005，10（8）：647-663；quiz672. DOI：10.1017/s1092852900019611.
[10]	SATEIA M J. International classification of sleep disorders-third edition：highlights and modifications[J]. Chest，2014，146（5）：1387-1394. DOI：10.1378/chest.14-0970.
[11]	SACK R L，AUCKLEY D，AUGER R R，et al. Circadian rhythm sleep disorders：part II，advanced sleep phase disorder，delayed sleep phase disorder，free-running disorder，and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review[J]. Sleep，2007，30（11）：1484-1501.
[12]	ARCHER S N，CARPEN J D，GIBSON M，et al. Polymorphism in the PER3 promoter associates with diurnal preference and delayed sleep phase disorder[J]. Sleep，2010，33（5）：695-701. DOI：10.1093/sleep/33.5.695.
[13]	MICIC G，LOVATO N，GRADISAR M，et al. The etiology of delayed sleep phase disorder[J]. Sleep Med Rev，2016，27：29-38. DOI：10.1016/j.smrv.2015.06.004.
[14]	SATOH K，MISHIMA K，INOUE Y，et al. Two pedigrees of familial advanced sleep phase syndrome in Japan[J]. Sleep，2003，26（4）：416-417. DOI：10.1093/sleep/26.4.416.
[15]	TOH K L，JONES C R，HE Y，et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome[J].Science，2001，291（5506）：1040-1043.
[16]	UCHIYAMA M，LOCKLEY S W. Non-24-hour sleep-wake rhythm disorder in sighted and blind patients[J]. Sleep Med Clin，2015，10（4）：495-516. DOI：10.1016/j.jsmc.2015.07.006.
[17]	CAMPBELL S S，DIJK D J，BOULOS Z，et al. Light treatment for sleep disorders：consensus report.Ⅲ.Alerting and activating effects[J]. J Biol Rhythms，1995，10（2）：129-132.
[18]	MORGENTHALER T I，LEE-CHIONG T，ALESSI C，et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders.An American Academy of Sleep Medicine report[J]. Sleep，2007，30（11）：1445-1459. DOI：10.1093/sleep/30.11.1445.
[19]	AUGER R R，MORGENTHALER T I. Jet lag and other sleep disorders relevant to the traveler[J]. Travel Med Infect Dis，2009，7（2）：60-68. DOI：10.1016/j.tmaid.2008.08.003.
[20]	SAMEL A，WEGMANN H M. Bright light：a countermeasure for jet lag?[J]. Chronobiol Int，1997，14（2）：173-183. DOI：10.3109/07420529709001154.
[21]	BOIVIN D B，JAMES F O. Circadian adaptation to night-shift work by judicious light and darkness exposure[J]. J Biol Rhythms，2002，17（6）：556-567. DOI：10.1177/0748730402238238.
[22]	ZISAPEL N. Circadian rhythm sleep disorders：pathophysiology and potential approaches to management[J]. CNS Drugs，2001，15（4）：311-328. DOI：10.2165/00023210-200115040-00005.
[23]	ABBOTT S M，ZEE P C. Irregular sleep-wake rhythm disorder[J]. Sleep Med Clin，2015，10（4）：517-522. DOI：10.1016/j.jsmc.2015.08.005.
[24]	CZEISLER C A，DUFFY J F，SHANAHAN T L，et al. Stability，precision，and near-24-hour period of the human circadian pacemaker[J]. Science，1999，284（5423）：2177-2181. DOI：10.1126/science.284.5423.2177.
[25]	MASRI S，SASSONE-CORSI P. The circadian clock：a framework linking metabolism，epigenetics and neuronal function[J]. Nat Rev Neurosci，2013，14（1）：69-75. DOI：10.1038/nrn3393.
[26]	ARENDT J. Melatonin，circadian rhythms，and sleep[J]. N Engl J Med，2000，343（15）：1114-1116.
[27]	DIJK D J，VON SCHANTZ M. Timing and consolidation of human sleep，wakefulness，and performance by a symphony of oscillators[J]. J Biol Rhythms，2005，20（4）：279-290. DOI：10.1177/0748730405278292.
[28]	LOVATO N，LACK L. The role of bright light therapy in managing insomnia[J]. Sleep Med Clin，2013，8（3）：351-359. DOI：10.1016/j.jsmc.2013.06.003.
[29]	SACK R L，AUCKLEY D，AUGER R R，et al. Circadian rhythm sleep disorders：part I，basic principles，shift work and jet lag disorders[J]. Sleep，2007，30（11）：1460-1483. DOI：10.1093/sleep/30.11.1460.
[30]	REID K J. Assessment of circadian rhythms[J]. Neurol Clin，2019，37（3）：505-526. DOI：10.1016/j.ncl.2019.05.001.
[31]	YOSHIMURA T，YASUO S，SUZUKI Y，et al. Identification of the suprachiasmatic nucleus in birds[J]. Am J Physiol Regul Integr Comp Physiol，2001，280（4）：R1185-1189. DOI：10.1152/ajpregu.2001.280.4.R1185.
[32]	LUCAS R J，PEIRSON S N，BERSON D M，et al. Measuring and using light in the melanopsin age[J]. Trends Neurosci，2014，37（1）：1-9. DOI：10.1016/j.tins.2013.10.004.
[33]	CHANG A M，SANTHI N，ST HILAIRE M，et al. Human responses to bright light of different durations[J].J Physiol，2012，590（13）：3103-3112. DOI：10.1113/jphysiol.2011.226555.
[34]	SANTHI N，THORNE H C，VAN DER VEEN D R，et al. The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans[J]. J Pineal Res，2012，53（1）：47-59. DOI：10.1111/j.1600-079X.2011.00970.x.
[35]	GOOLEY J J，RAJARATNAM S M，BRAINARD G C，et al. Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light[J]. Sci Transl Med，2010，2（31）：31ra33. DOI：10.1126/scitranslmed.3000741.
[36]	KHALSA S B S，JEWETT M E，CAJOCHEN C，et al. A phase response curve to single bright light pulses in human subjects[J].J Physiol，2003，549（3）：945-952. DOI：10.1113/jphysiol.2003.040477.
[37]	REITER A M，SARGENT C，ROACH G D. Finding DLMO：estimating dim light melatonin onset from sleep markers derived from questionnaires，diaries and actigraphy[J].Chronobiol Int，2020，37（9/10）：1412-1424. DOI：10.1080/07420528.2020.1809443.
[38]	MINORS D S，WATERHOUSE J M，WIRZ-JUSTICE A. A human phase-response curve to light[J]. Neurosci Lett，1991，133（1）：36-40. DOI：10.1016/0304-3940(91)90051-t.
[39]	ZEITZER J M，DIJK D J，KRONAUER R E，et al. Sensitivity of the human circadian pacemaker to nocturnal light：melatonin phase resetting and suppression[J]. J Physiol，2000，526（3）：695-702. DOI：10.1111/j.1469-7793.2000.00695.x.
[40]	HANKINS M W，PEIRSON S N，FOSTER R G. Melanopsin：an exciting photopigment[J]. Trends Neurosci，2008，31（1）：27-36. DOI：10.1016/j.tins.2007.11.002.
[41]	VAN MAANEN A，MEIJER A M，VAN DER HEIJDEN K B，et al. The effects of light therapy on sleep problems：a systematic review and meta-analysis[J]. Sleep Med Rev，2016，29：52-62. DOI：10.1016/j.smrv.2015.08.009.
[42]	ROSENTHAL N E，JOSEPH-VANDERPOOL J R，LEVENDOSKY A A，et al. Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome[J]. Sleep，1990，13（4）：354-361.
[43]	COLE R J，SMITH J S，ALCALÁ Y C，et al. Bright-light mask treatment of delayed sleep phase syndrome[J]. J Biol Rhythms，2002，17（1）：89-101. DOI：10.1177/074873002129002366.
[44]	LACK L，BRAMWELL T，WRIGHT H，et al. Morning blue light can advance the melatonin rhythm in mild delayed sleep phase syndrome[J]. Sleep Biol Rhythm，2007，5（1）：78-80. DOI：10.1111/j.1479-8425.2006.00250.x.
[45]	OBAYASHI K，SAEKI K，KURUMATANI N. Association between light exposure at night and insomnia in the general elderly population：the HEIJO-KYO cohort[J]. Chronobiol Int，2014，31（9）：976-982. DOI：10.3109/07420528.2014.937491.
[46]	CAMPBELL S S，DAWSON D，ANDERSON M W. Alleviation of sleep maintenance insomnia with timed exposure to bright light[J].J Am Geriatr Soc，1993，41（8）：829-836. DOI：10.1111/j.1532-5415.1993.tb06179.x.
[47]	PALMER C R，KRIPKE D F，SAVAGE H C Jr，et al. Efficacy of enhanced evening light for advanced sleep phase syndrome[J].Behav Sleep Med，2003，1（4）：213-226. DOI：10.1207/S15402010BSM0104_4.
[48]	BOIVIN D B，JAMES F O. Circadian adaptation to night-shift work by judicious light and darkness exposure[J]. J Biol Rhythms，2002，17（6）：556-567. DOI：10.1177/0748730402238238.
[49]	HUANG L B，TSAI M C，CHEN C Y，et al. The effectiveness of light/dark exposure to treat insomnia in female nurses undertaking shift work during the evening/night shift[J]. J Clin Sleep Med，2013，9（7）：641-646. DOI：10.5664/jcsm.2824.
[50]	EASTMAN C I，GAZDA C J，BURGESS H J，et al. Advancing circadian rhythms before eastward flight：a strategy to prevent or reduce jet lag[J]. Sleep，2005，28（1）：33-44. DOI：10.1093/sleep/28.1.33.
[51]	DANIELSSON K，JANSSON-FRÖJMARK M，BROMAN J E，et al. Cognitive behavioral therapy as an adjunct treatment to light therapy for delayed sleep phase disorder in young adults：a randomized controlled feasibility study[J]. Behav Sleep Med，2016，14（2）：212-232. DOI：10.1080/15402002.2014.981817.
[52]	GRADISAR M，DOHNT H，GARDNER G，et al. A randomized controlled trial of cognitive-behavior therapy plus bright light therapy for adolescent delayed sleep phase disorder[J]. Sleep，2011，34（12）：1671-1680. DOI：10.5665/sleep.1432.
[53]	DANIELSSON K，JANSSON-FRÖJMARK M，BROMAN J E，et al. Light therapy with scheduled rise times in young adults with delayed sleep phase disorder：therapeutic outcomes and possible predictors[J]. Behav Sleep Med，2018，16（4）：325-336. DOI：10.1080/15402002.2016.1210150.
[54]	HOROWITZ T S，CADE B E，WOLFE J M，et al. Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work[J]. Am J Physiol Endocrinol Metab，2001，281（2）：E384-391. DOI：10.1152/ajpendo.2001.281.2E384.
[55]	SAXVIG I W，WILHELMSEN-LANGELAND A，PALLESEN S，et al. A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder：effects on subjective and objective sleep[J]. Chronobiol Int，2014，31（1）：72-86. DOI：10.3109/07420528.2013.823200.
[56]	MUNDEY K，BENLOUCIF S，HARSANYI K，et al. Phase-dependent treatment of delayed sleep phase syndrome with melatonin[J]. Sleep，2005，28（10）：1271-1278. DOI：10.1093/sleep/28.10.1271.
[57]	CROWLEY S J，EASTMAN C I. Phase advancing human circadian rhythms with morning bright light，afternoon melatonin，and gradually shifted sleep：can we reduce morning bright-light duration?[J]. Sleep Med，2015，16（2）：288-297. DOI：10.1016/j.sleep.2014.12.004.
[58]	WILHELMSEN-LANGELAND A，SAXVIG I W，PALLESEN S，et al. A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder：effects on subjective and objective sleepiness and cognitive function[J]. J Biol Rhythms，2013，28（5）：306-321. DOI：10.1177/0748730413500126.
[59]	WULFF K，GATTI S，WETTSTEIN J G，et al. Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease[J]. Nat Rev Neurosci，2010，11（8）：589-599. DOI：10.1038/nrn2868.
[60]	SHORT M A，LOUC A. Sleep deprivation leads to mood deficits in healthy adolescents[J]. Sleep Med，2015，16（8）：987-993. DOI：10.1016/j.sleep.2015.03.007.
[61]	FAULKNER S M，BEE P E，MEYER N，et al. Light therapies to improve sleep in intrinsic circadian rhythm sleep disorders and neuro-psychiatric illness：a systematic review and meta-analysis[J]. Sleep Med Rev，2019，46：108-123. DOI：10.1016/j.smrv.2019.04.012.
[62]	KIRSCHBAUM I，STRAUB J，GEST S，et al. Short-term effects of wake- and bright light therapy on sleep in depressed youth[J]. Chronobiol Int，2018，35（1）：101-110. DOI：10.1080/07420528.2017.1388251.
[63]	FARGASON R E，FOBIAN A D，HABLITZ L M，et al. Correcting delayed circadian phase with bright light therapy predicts improvement in ADHD symptoms：a pilot study[J]. J Psychiatr Res，2017，91：105-110. DOI：10.1016/j.jpsychires.2017.03.004.
[64]	SNITSELAAR M A，SMITS M G，VAN DER HEIJDEN K B，et al. Sleep and circadian rhythmicity in adult ADHD and the effect of stimulants[J]. J Atten Disord，2017，21（1）：14-26. DOI：10.1177/1087054713479663.
[65]	BROMUNDT V，WIRZ-JUSTICE A，KYBURZ S，et al. Circadian sleep-wake cycles，well-being，and light therapy in borderline personality disorder[J]. J Pers Disord，2013，27（5）：680-696. DOI：10.1521/pedi_2012_26_057.
[66]	ANCOLI-ISRAEL S，GEHRMAN P，MARTIN J L，et al. Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's disease patients[J].Behav Sleep Med，2003，1（1）：22-36. DOI：10.1207/S15402010BSM0101_4.
[67]	DOWLING G A，BURR R L，VAN SOMEREN E J，et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease[J]. J Am Geriatr Soc，2008，56（2）：239-246. DOI：10.1111/j.1532-5415.2007.01543.x.
[68]	RIEMERSMA-VAN DER LEK R F，SWAAB D F，TWISK J，et al. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities：a randomized controlled trial[J]. JAMA，2008，299（22）：2642-2655. DOI：10.1001/jama.299.22.2642.
[69]	RUBIÑO J A，GAMUNDÍ A，AKAARIR M，et al. Bright light therapy and circadian cycles in institutionalized Elders[J]. Front Neurosci，2020，14：359. DOI：10.3389/fnins.2020.00359.
[70]	MCCURRY S M，GIBBONS L E，LOGSDON R G，et al. Nighttime insomnia treatment and education for Alzheimer's disease：a randomized，controlled trial[J]. J Am Geriatr Soc，2005，53（5）：793-802. DOI：10.1111/j.1532-5415.2005.53252.x.
[71]	WILLIS G L，TURNER E J D. Primary and secondary features of Parkinson's disease improve with strategic exposure to bright light：a case series study[J]. Chronobiol Int，2007，24（3）：521-537. DOI：10.1080/07420520701420717.
[72]	WILLIS G L，MOORE C，ARMSTRONG S M. A historical justification for and retrospective analysis of the systematic application of light therapy in Parkinson's disease[J].Rev Neurosci，2012，23（2）：199-226. DOI：10.1515/revneuro-2011-0072.
[73]	ROGERS V E，MOWBRAY C，RAHMATY Z，et al. A morning bright light therapy intervention to improve circadian health in adolescent cancer survivors：methods and preliminary feasibility[J]. J Pediatr Oncol Nurs，2021，38（2）：70-81. DOI：10.1177/1043454220975457.
[74]	ANCOLI-ISRAEL S，MARTIN J L，KRIPKE D F，et al. Effect of light treatment on sleep and circadian rhythms in demented nursing home patients[J]. J Am Geriatr Soc，2002，50（2）：282-289. DOI：10.1046/j.1532-5415.2002.50060.x.
[75]	FORBES D，BLAKE C M，THIESSEN E J，et al. Light therapy for improving cognition，activities of daily living，sleep，challenging behaviour，and psychiatric disturbances in dementia[J].Cochrane Database Syst Rev，2014（2）：CD003946. DOI：10.1002/14651858.CD003946.pub4.

Role of Light Therapy in Circadian Rhythm Sleep-wake Disorders

光疗在昼夜节律睡眠-觉醒障碍中的应用进展

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