Abstract: HAN Ying，Chief physician，Professor，Doctoral supervisor；E-mail：hanying@xwh.ccmu.edu.cn
Background　The development of simple tools for early screening for subjective cognitive decline（SCD），an early manifestation of Alzheimer's disease（AD），is beneficial to early clinical identification of AD.However，some cases of mild cognitive impairment（MCI）may score 0 by completing the 9-item Chinese version of Subjective Cognitive Decline Questionnaire（SCD-Q9-C），which may be associated with insufficient coverage of subjective complaints about SCD.Objective　To modify the SCD-Q9-C to be a 21-item questionnaire（SCD-Q21-C）by adding items screening for SCD selected from the unabridged item pool of SCD-Q21.Methods　After obtaining the permission or authorization of authors of SCD-Q21，we chinesized the SCD-Q21 following the standardized process for localizing foreign questionnaires from 1 July to 31 August 2020，using the Brislin's model for translation and validation of instruments for cross-cultural research，including word-for-word translation，and back-translation，done independently by two individuals，and revised the items for cultural adaptation through panel discussions and a pre-test with a small sample size.Results　After a strict process of chinesization（translation，back-translation，comparison of the back-translation to the original content，item revision，cultural adjustment and a pre-test with a small sample size），the final SCD-Q21-C（with 21 points as the full score）was developed，consisting of 6 three-choice items（the 4th，5th，7th，10th，20th and 21st items）and 15 two-choice items；2 reverse items（the 11th and 19th items）and 19 positive items.Conclusion　The development of SCD-Q21-C is contributive to the further use of SCD-Q in Chinese population，and offers a reference for exploring simple tools for early screening for AD.

Key words: Alzheimer disease, Subjective cognitive decline, Screening, SCD-Q

摘要： 背景　主观认知下降（SCD）是阿尔茨海默病（AD）患者的早期表现之一，其早期简易筛查工具的研发有利于帮助临床早期识别AD，但部分轻度认知障碍（MCI）患者主观认知下降问卷9（SCD-Q9）为0分，可能与该问卷未涵盖所有SCD主诉有关。目的　对筛选出SCD-Q9的上位条目池即主观认知下降问卷21（SCD-Q21）进行汉化，找出可识别SCD风险的SCD主诉条目并进一步优化SCD-Q9。方法　2020-07-01至2020-08-31，参考国外问卷本土化标准程序，经原作者授权、同意后获得英文版原版问卷，采用Brislin“两人直译?回译”法对SCD-Q21进行汉化，并通过专家小组讨论及小样本预调查进行条目修订及文化调适。结果　本研究经严格的翻译、回译、对比回译、条目修订、文化调适及小样本预调查而形成中文版SCD-Q21终稿。中文版SCD-Q21终稿由21个条目组成，其中条目4、5、7、10、20、21为三分类选项，其余均为二分类选项；条目11、19为反向条目，其余均为正向条目；总分21分。结论　中文版SCD-Q21终稿的形成为后续该问卷在中国人群中的运用奠定了坚实基础，也为AD早期简易筛查工具的探索提供了一种方法。

关键词: 阿尔茨海默病, 主观认知下降, 筛查, 主观认知下降问卷