Abstract: Objective　To analysis the effects of H.pylori infection on metabolic indicators in elderly and young/middle-age people.Methods　A retrospective study was conducted，based on the clinical data from 1 828 subjects found to be healthy during physical examinations in the General Hospital of the PLA Rocket Force between May 2017 and June 2017.According to the presence of H.pylori infection，the subjects were divided into an H.pylori-positive group and an H.pylori-negative group.The subjects were further divided into an elderly H.pylori-positive subgroup，an elderly H.pylori-negative subgroup，a young/middle-age H.pylori-positive subgroup，and a young/middle-age H.pylori-negative subgroup，with 60 years of age as the cutoff.The data from physical examinations，including systolic blood pressure，diastolic blood pressure，fasting blood glucose，postprandial blood glucose，alanine aminotransferase，total cholesterol，triacylglycerol，high-density lipoprotein cholesterol，low-density lipoprotein cholesterol，13C breath test and abdominal ultrasound，were collected and analyzed.Results　The level of systolic blood pressure，diastolic blood pressure and postprandial blood glucose，and the rates of systolic blood pressure，diastolic blood pressure and fasting blood glucose in the H.pylori-positive group（n=580） were higher than those in the H.pylori-negative group（n=1 248）（P<0.05）.The rates of abnormal diastolic blood pressure and fasting blood glucose in the elderly H.pylori-positive subgroup（n=143） were higher than the elderly H.pylori-negative subgroup（n=287）（P<0.05）.Systolic blood pressure，diastolic blood pressure，postprandial blood glucose，alanine aminotransferase and triacylglycerol were higher，and high-density lipoprotein cholesterol was lower，in the young/middle-age H.pylori-positive subgroup（n=437） than the young/middle-age H.pylori-negative subgroup（n=961）（P<0.05）.The rates of abnormal systolic blood pressure，diastolic blood pressure，fasting blood glucose and triacylglycerol，the incidence of nonalcoholic fatty liver disease in the young/middle-age H.pylori-positive subgroup were higher than the young/middle-age H.pylori-negative subgroup（P<0.05）.Conclusion　H.pylori infection may affect body metabolism，and the infection has a greater effect on the metabolism of young and middle-age people than elderly people.Eradication of H.pylori should be pursued among young and middle-age infected patients，and elderly patients should be treated individually.

Key words: Helicobacter pylori, Metabolic syndrome X, Fatty liver, Blood glucose, Blood pressure

摘要： 目的　分析幽门螺杆菌（H.pylori）感染对老年和中青年代谢指标的影响。方法　2017年5—6月对在火箭军总医院进行健康体检者1 828例的临床资料进行回顾性分析。按照是否感染H.pylori分为H.pylori阳性组和H.pylori阴性组。再以年龄≥60岁为界，分为老年H.pylori阳性亚组、老年H.pylori阴性亚组，中青年H.pylori阳性亚组、中青年H.pylori阴性亚组。收集体检者收缩压、舒张压、空腹血糖、餐后血糖、丙氨酸氨基转移酶、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、13C呼气试验结果和腹部超声检查结果。结果　H.pylori阳性组（n=580）收缩压、舒张压、餐后血糖及收缩压、舒张压、空腹血糖异常率高于H.pylori阴性组（n=1 248）（P<0.05）。老年H.pylori阳性亚组（n=143）的舒张压、空腹血糖异常率高于老年H.pylori阴性亚组（n=287）（P<0.05）。中青年H.pylori阳性亚组（n=437）收缩压、舒张压、餐后血糖、丙氨酸氨基转移酶、三酰甘油和收缩压、舒张压、空腹血糖、三酰甘油异常率及非酒精性脂肪肝发病率高于中青年H.pylori阴性亚组（n=961），高密度脂蛋白胆固醇低于中青年H.pylori阴性亚组（P<0.05）。结论　H.pylori感染后会对代谢指标产生影响，其对中青年代谢指标的影响明显大于老年。应该对于中青年感染人群应该积极地行根除H.pylori治疗，对于老年感染者应该个体化对待。

关键词: 幽门螺杆菌, 代谢综合征X, 脂肪肝, 血糖, 血压