Advancements in the Treatment of Endometrial Hypofunction Diseases Using Menstrual Blood-derived Endometrium Stem Cells Combined with Traditional Chinese Medicine for Tonifying Kidney and Activating Blood in Regenerative Medicine

doi:10.12114/j.issn.1007-9572.2024.0413

Abstract

Abstract:

In an environment where conventional therapeutic methods have limited effectiveness in treating endometrial hypoplasia, cellular therapies, especially stem cell technology, have demonstrated significant potential for innovation and efficacy. This review explored the advancements in menstrual stem cell (MenSC) research and examined the outcomes and future prospects of combining MenSCs with Chinese medicine for tonifying kidney and activating blood. We investigated the mechanisms of endometrial hypoplasia from the perspectives of pharmacological prescriptions and MenSCs, and subsequently discussed the potential of MenSCs, along with Chinese medicine for tonifying kidney and activating blood, within the innovative field of treating this condition. The purpose of this review was to promote the deep integration of regenerative medicine with Chinese medicine and materials science through summarizing the effectiveness of stem cell therapy, thereby revealing new strategies for more comprehensive and personalized treatment approaches.

Key words: Endometrial dysfunction, Menstrual blood-derived stem cells, Traditional Chinese medicine for tonifying kidney and activating blood, Review

摘要：

在传统治疗策略对子宫内膜功能减退类疾病治疗效果受限的环境下，细胞疗法尤其是干细胞技术在创新性与疗效上展示着显著潜力。本综述深入讨论了经血源性干细胞（MenSCs）的研究进展以及其与补肾活血类中药联合治疗的成果与前景，从方药和MenSCs角度探讨二者治疗子宫内膜功能减退类疾病的机制，进而对MenSCs与补肾活血类中药在创新性领域应用治疗该病症进行可行性探讨。本文旨在通过综述干细胞疗法的疗效，以推动再生医学与中医药学、材料学的深度融合，从而开辟更为全面且个性化的治疗新策略。

关键词: 子宫内膜功能减退类疾病, 经血源性干细胞, 补肾活血类中药, 综述

CLC Number:

R 711.74

SUN Yuchen,SHI Yaxin,SHI Wei. Advancements in the Treatment of Endometrial Hypofunction Diseases Using Menstrual Blood-derived Endometrium Stem Cells Combined with Traditional Chinese Medicine for Tonifying Kidney and Activating Blood in Regenerative Medicine[J]. Chinese General Practice, 2026, 29(11): 1481-1487. DOI: 10.12114/j.issn.1007-9572.2024.0413.
孙宇辰,石雅馨,师伟. 经血源性干细胞联合补肾活血类中药治疗子宫内膜功能减退类疾病的研究进展[J]. 中国全科医学, 2026, 29(11): 1481-1487. DOI: 10.12114/j.issn.1007-9572.2024.0413.

Figures/Tables 1

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材料	特点	应用	参考文献
氧化透明质酸、乙二醇壳聚糖（GC）和MenSCs	通过动态席夫碱连接实现了快速原位形成，并具有自愈合能力	肝切除术后肝细胞的增殖和组织再生	[64]
DSCG与GelMA水凝胶混合并搭载MenSCs	减轻炎症，还可以促进轴突再生和神经元发育，抑制胶质瘢痕形成	减轻脊髓损伤创面炎症反应，促进神经元分化	[65]
VitroGel MMP水凝胶系统与MenSCs	增强生物相容性和可生物降解性，为细胞生长提供优化的环境，支持各种生物活性	子宫内膜容受性降低导致的生育功能障碍	[66]
富含羊膜提取物精氨酰-甘氨酰-天冬氨酸水凝胶联合MenSCs	富含多种生长因子和细胞因子，抗炎和伤口愈合能力出色	子宫内膜再生，减少纤维化，提高生育能力	[67]

材料	特点	应用	参考文献
氧化透明质酸、乙二醇壳聚糖（GC）和MenSCs	通过动态席夫碱连接实现了快速原位形成，并具有自愈合能力	肝切除术后肝细胞的增殖和组织再生	[64]
DSCG与GelMA水凝胶混合并搭载MenSCs	减轻炎症，还可以促进轴突再生和神经元发育，抑制胶质瘢痕形成	减轻脊髓损伤创面炎症反应，促进神经元分化	[65]
VitroGel MMP水凝胶系统与MenSCs	增强生物相容性和可生物降解性，为细胞生长提供优化的环境，支持各种生物活性	子宫内膜容受性降低导致的生育功能障碍	[66]
富含羊膜提取物精氨酰-甘氨酰-天冬氨酸水凝胶联合MenSCs	富含多种生长因子和细胞因子，抗炎和伤口愈合能力出色	子宫内膜再生，减少纤维化，提高生育能力	[67]