Knee osteoarthritis (KOA) is the fourth most disabling disease globally, with an increasing incidence and disability rate. Frailty is associated with KOA and significantly reduces the quality of life of KOA patients.

To conduct a scoping review of the current status of frailty in KOA patients, assessment tools, influencing factors, and intervention measures, in order to provide theoretical support for early prediction of frailty progression and personalized intervention measures.

A systematic review was conducted using a combination of subject headings and free terms to search for relevant studies on the prevalence, assessment tools, influencing factors, and intervention methods for frailty in patients with KOA in Web of Science, PubMed, Embase, Cochrane Library, CNKI, Wanfang Data, VIP, and SinoMed. The search period was from the establishment of the databases to December 12, 2024. Two researchers independently summarized, categorized, and analyzed the literature data.

A total of 13 articles were finally included. The study results showed that the incidence of frailty in KOA patients was 8.2% to 67.8%, and the incidence and severity of frailty in patients were different in different studies. There were many types of assessment tools, but there was a lack of specific assessment tools in general. The commonly used tools in the study were the SOF index, the FRAIL scale, and the Fried phenotype. The influencing factors mainly included demographic and social factors, disease-related factors, and psychological and behavioral factors. The intervention measures included exercise training, combined Traditional Chinese Medicine and exercise therapy, and injection therapy.

The incidence of frailty in KOA patients varies to some extent, there is a lack of specific assessment tools now, and a more suitable frailty prediction assessment tool for KOA patients in China can be compiled in the future to provide a time node for precise intervention of frailty. Meanwhile, focus should be placed on the risk factors that affect the frailty of KOA patients to delay the progression of frailty and improve their quality of life.

膝骨关节炎（KOA）是全球第四大致残性疾病，其发生率和致残率逐年升高。衰弱与KOA相互关联，严重降低KOA患者生活质量。

对KOA患者衰弱的发生现状、评估工具、影响因素和干预措施进行范围综述，为有效早期预测衰弱进展，制订个性化的干预措施提供理论支持。

采取主题词和自由词相结合的方法，检索Web of Science、PubMed、Embase、Cochrane Library及中国知网、万方数据知识服务平台、维普网、中国生物医学文献服务系统中有关KOA患者衰弱发生现状、评估工具、影响因素及干预方法的相关研究，检索期限为建库至2024-12-12。由2名研究者独立对文献数据进行汇总、归类及分析。

最终纳入13篇文献，研究结果显示KOA患者衰弱的发生率为8.2%~67.8%，患者衰弱发生率和严重程度在不同研究结果之间存在一定差异；评估工具种类多，但总体上缺乏特异性评估工具，研究中较为常用的工具为骨质疏松性骨折研究（SOF）指数、FRAIL量表及Fried衰弱表型；影响因素主要包括社会人口学因素、疾病相关因素及心理行为因素；干预措施包括运动训练、中医联合运动治疗以及注射治疗。

KOA患者衰弱发生率存在一定程度差异，且缺少特异性的评估工具，未来可编制更适合我国KOA患者的衰弱预测评估工具，为精准干预衰弱提供参考；同时应聚焦影响KOA患者衰弱的危险因素，以延缓KOA患者衰弱进展，提升其生活质量。