Inflammatory bowel disease (IBD) patients suffer from recurrent and prolonged disease episodes, resulting in a high disease burden, which seriously affects patients' quality of life. Different types of disease burden have different impacts on the health status of patients, however, the current distribution of disease burden types in IBD patients and their influencing factors are not clear and need to be further explored.

To explore the potential profiles of disease burden in patients with IBD, and to analyze the influencing factors of different potential profiles.

Convenience sampling method was used to select 241 IBD patients from Tenth People's Hospital, Tongji University from June to October 2023. General information questionnaire, Chinese version of the Inflammatory Bowel Disease Disk Scale, and Psychological Resilience Scale were used to conduct the survey. Potential profile analysis was categorized the burden of disease for IBD patients, and multiple Logistic regression was explored the differences in the characteristics of different categories of patients.

A total of 250 questionnaires were distributed in this study and 241 valid questionnaires were recovered, with a valid questionnaire recovery rate of 96.4%. The disease burden characteristics of IBD patients could be categorized into 3 potential profiles: high burden-disease coping difficulties type (n=147, 61.0%) , medium burden-perceived pain and image type (n=75, 31.1%) , and low burden-psycho-emotional type (n=19, 7.9%) . The results of multiple Logistic regression analysis showed that the high burden-disease coping difficulties type was compared with the low burden-psycho-emotional type, patients with unstable jobs and high education level were easily categorized into high burden-disease coping difficulties type, while patients with high annual income, long disease duration, no complications and favorable psychological resilience were easily categorized into low burden-psycho-emotional type. Comparing the medium burden-perceived pain and image type with the low burden-psycho-emotional type, the older the patients, the higher the literacy level, the higher the number of follow-ups, and the lack of surgical experience were easily categorized into the medium burden-perceived pain and image type, and the patients with high annual income, long disease duration, no complications, and favorable psychological resilience were easily categorized into the low burden-psycho-emotional type. Comparing the medium burden-perceived pain and image type with the high burden-disease coping difficulties type patients who were married, had no regular job, and had long disease duration were likely to be categorized in the high burden-disease coping difficulties type, whereas patients who had a high number of follow-ups and no surgical treatment were likely to be categorized in the medium burden-perceived pain and image type (P<0.05) .

The disease burden of IBD patients has a distinct categorical profile and is divided into three potential profiles: high burden-disease coping difficulties type, medium burden-perceived pain and image type, and low burden-psycho-emotional type, which are influenced by age, marital status, job status, education level, annual income, disease duration, frequency of follow-up, surgical experience, complications, and level of psychological resilience. Healthcare professionals should pay attention to identifying the disease burden levels of different patients, focusing on high-burden patients, strengthening IBD symptom management and psychological interventions, and improving patients' disease coping ability and psychological resilience levels to reduce their disease burden.

炎症性肠病（IBD）患者因疾病反复发作且迁延不愈，导致较高的疾病负担，严重影响患者的生活质量。不同负担程度对患者健康状况产生不同影响，然而IBD患者的疾病负担类型分布特征和影响因素尚不明确，有待进一步探究。

探讨IBD患者疾病负担的潜在剖面，分析不同潜在剖面的影响因素。

采用便利抽样法，于2023年6—10月，选取同济大学附属第十人民医院就诊的IBD患者作为研究对象。采用一般资料调查问卷、中文版炎症性肠病患者疾病负担程度量表及心理弹性量表对其进行调查。采用潜在剖面分析对IBD患者疾病负担进行分类，多元Logistic回归分析探讨不同类别患者的特征差异。

本研究共发放问卷250份，回收有效问卷241份，有效问卷回收率为96.4%。IBD患者的疾病负担特征可分为3个类别：高负担-疾病应对困难组（n=147，61.0%）、中负担-感知疼痛与形象组（n=75，31.1%）、低负担-心理情绪组（n=19，7.9%）。多元Logistic回归分析结果显示，高负担-疾病应对困难组与低负担-心理情绪组相比较，无固定工作、文化程度高的患者易归入高负担-疾病应对困难组，家庭年收入高、病程长、无并发症、心理弹性良好的患者易归入低负担-心理情绪组；中负担-感知疼痛与形象组与低负担-心理情绪组比较，年龄越大、文化程度高、复诊次数多、无手术经历的患者易归入中负担-感知疼痛与形象组，家庭年收入高、病程长、无并发症、心理弹性良好的患者易归入低负担-心理情绪组；中负担-感知疼痛与形象组与高负担-疾病应对困难组比较，已婚、无固定工作、病程长的患者易归入高负担-疾病应对困难组，而复诊次数多、无手术治疗的患者易归入中负担-感知疼痛与形象组（P<0.05）。

IBD患者的疾病负担具有明显的分类特征，分为高负担-疾病应对困难组、中负担-感知疼痛与形象组、低负担-心理情绪组3个潜在剖面，其影响因素是年龄、婚姻情况、工作情况、文化程度、年收入、病程、复诊次数、手术经历、并发症和心理弹性水平。医护人员应注意鉴别不同患者的疾病负担水平，重点关注高负担患者，加强IBD症状管理和心理干预措施，提高患者的疾病应对能力和心理弹性水平，减轻其疾病负担。