Progress of Research on Mechanism of Intestinal Nervous System Regulating Intestinal Inflammation Based on Intestinal Stem Cells

doi:10.12114/j.issn.1007-9572.2023.0245

Abstract

Abstract:

Intestinal stem cells are regulated by the intestinal nervous system, and both of them are closely related to intestinal inflammation. Relevant studies have shown the existence of intestinal nerve dysfunction in intestinal inflammation. By summarizing the relationship among intestinal stem cells, intestinal nervous system and intestinal inflammation, this paper discusses that intestinal nervous system injury related to intestinal inflammation may be the basis for persistent alteration of intestinal function, while enteric neurons provide feasible targets for improving intestinal nerve dysfunction in inflammatory bowel diseases, so as to apply various types of stem cells to the improvement of intestinal nerve dysfunction in intestinal inflammation.

Key words: Intestinal inflammation, Inflammatory bowel diseases, Stem cell, Enteric nervous system, Therapy, Review

摘要：

肠道干细胞受到肠神经系统调控，肠道干细胞与肠神经系统均与肠道炎症存在密切联系。相关研究表明肠道炎症中存在肠神经功能障碍，本文通过总结肠道干细胞、肠神经系统与肠道炎症三者之间的关系，探讨肠道炎症相关的肠神经系统损伤可能是肠道功能持续改变的基础，而肠神经元等为改善肠道炎症性疾病中出现的肠神经功能障碍提供了可行靶点，以期将多种类型干细胞用于改善肠道炎症中出现的肠神经功能障碍。

关键词: 肠道炎症, 炎性肠疾病, 干细胞, 肠神经系统, 治疗, 综述

CLC Number:

R 574

CHEN Siqi,XIAO Jin,TIAN Siyu, et al. Progress of Research on Mechanism of Intestinal Nervous System Regulating Intestinal Inflammation Based on Intestinal Stem Cells[J]. Chinese General Practice, 2024, 27(23): 2858-2863. DOI: 10.12114/j.issn.1007-9572.2023.0245.
陈思琪,肖瑾,田思雨等. 基于肠道干细胞探讨肠神经系统调节肠道炎症的机制研究进展[J]. 中国全科医学, 2024, 27(23): 2858-2863. DOI: 10.12114/j.issn.1007-9572.2023.0245.

Figures/Tables 2

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