Colorectal cancer has become the third most prevalent malignant tumor in Jiading district of Shanghai, and its disease burden is still increasing.

To analyze the epidemic trend of colorectal cancer in Jiading district of Shanghai from 2003 to 2019 and provide scientific basis for the prevention and treatment of colorectal cancer.

Based on the cancer registration data from 2003 to 2019 in Jiading district of Shanghai, the statistical indicators such as crude incidence rate, crude mortality rate, standardized incidence rate and standardized mortality rate were calculated (the rate was standardized using the Chinese standard population of 2010). Joinpoint Regression Program 4.9.1.0 software was used to analyze the trends of incidence rate and mortality rate.

From 2003 to 2019, there were 5 020 new cases of colorectal cancer in Jiading district of Shanghai, with a crude incidence rate of 52.12/100 000, a standardized incidence rate of 26.27/100 000; there were 2 419 deaths, with a crude mortality rate of 25.12/100 000, and a standardized mortality rate of 11.16/100 000; with males having higher crude incidence and crude mortality rates than females (P<0.05). There was an overall upward trend in the total population standardized incidence rate (APC=2.63%, P<0.05), with an increasing trend in the male standardized incidence rate (APC=3.48%, P<0.05), and no significant trend in the female standardized incidence rate (APC=1.39%, P=0.119), while no turning point was found. There was no significant trend in the total population standardized mortality rate (APC=-0.49%, P=0.250), of which there was no significant trend in the male standardized mortality rate (APC=0.34%, P=0.545), and a decreasing trend in the female standardized mortality rate (APC=-1.94%, P<0.05) .

From 2003 to 2019, the overall incidence rate of colorectal cancer in Jiading district of Shanghai still increased, among which there was an upward trend in males and no significant change in the trend for females. There was no significant trend in the overall mortality rate, among which there was no significant change in males and a downward trend in females. The prevention and control of colorectal cancer should continue to be strengthened, with a focus on the male population.

结直肠癌已成为上海市嘉定区发病率排名第三的恶性肿瘤，其疾病负担仍在加重。

分析2003—2019年上海市嘉定区结直肠癌流行趋势，为结直肠癌防治提供科学依据。

基于2003—2019年上海市嘉定区肿瘤登记资料，计算粗发病率、粗死亡率、标化发病率、标化死亡率等统计指标（以2010年中国标准人口构成进行标化调整），利用Joinpoint Regression Program 4.9.1.0软件分析发病率和死亡率的变化趋势。

2003—2019年上海市嘉定区结直肠癌新发病例5 020例，粗发病率52.12/10万，标化发病率26.27/10万，死亡病例2 419例，粗死亡率25.12/10万，标化死亡率11.16/10万，男性的粗发病率和粗死亡率均高于女性（P<0.05）；总人群标化发病率总体呈现上升趋势（APC=2.63%，P<0.05），其中男性标化发病率呈上升趋势（APC=3.48%，P<0.05），女性标化发病率无明显变化趋势（APC=1.39%，P=0.119），均未发现转折点；总人群标化死亡率无明显变化趋势（APC=-0.49%，P=0.250），其中男性标化死亡率无明显变化趋势（APC=0.34%，P=0.545），女性标化死亡率呈现下降趋势（APC=-1.94%，P<0.05）。

2003—2019年上海市嘉定区结直肠癌总体发病率总体仍有上升，其中男性呈上升趋势，女性无明显变化趋势；总体死亡率无明显变化趋势，其中男性无明显变化，女性呈下降趋势，应继续加强结直肠癌的防控工作，重点关注男性人群。