Cognitive impairment can lead to a decline in cognitive function, depression, and loneliness, as well as decreased self-efficacy and quality of life in older adults.

To investigate the effects of non-pharmacological integrated interventions on cognitive function, depression, loneliness, self-efficacy, and quality of life in older adults with mild cognitive impairment.

Based on risk factors for cognitive impairment, a non-pharmacological integrated intervention program was developed in five dimensions of cognitive training, physical exercise, emotional management, social connection, and healthy lifestyle habits. Using a single-subject A-B-A experimental design, a 3-month intervention, which was conducted once a week for 60 minutes, was performed in three elderly individuals with mild cognitive impairment from June to December 2021. The Montreal Cognitive Assessment (MoCA), Geriatric Depression Scale-15 (GDS-15), 12-item Short Form Health Survey (SF-12), General Self-Efficacy Scale (GSES), and De Jong Gierveld Loneliness Scale (DJGLS) were administered to the 3 older adults at baseline, 3 months of the intervention, and 3 months after the intervention, to assess the scores of each scale from the 5 dimensions of cognitive function, self-efficacy, quality of life, depression, and loneliness, the changes in the scores were analyzed. A semi-structured interview was conducted 3 months after the intervention to evaluate the intervention effects in terms of cognitive function, quality of life, depression, self-efficacy, and loneliness dimensions.

The 3 older adults included in the study were 74, 70, 73 years old, all married, living with their spouses and grandchildren. The three older adults had MoCA scores of 21, 22, and 24 at baseline, 28, 26, and 27 at 3 months of intervention, and 25, 19, and 23 at 3 months after intervention; GSES scores were 25, 30, and 27 at baseline, 29, 29, and 30 at 3 months of intervention, and 28, 31, and 28 at 3 months after intervention. SF-12 scores were 69, 32, and 51 at baseline, 81, 81, and 83 at 3 months of intervention, and 78, 38, and 59 at 3 months after intervention. The GDS-15 scale scores were 4, 8, and 2 at baseline, 2, 6, and 1 at 3 months of intervention, and 1, 8, and 4 at 3 months after intervention. The DJGLS scores were 8, 7, and 8 at baseline, 5, 5, and 4 at 3 months of intervention, and 5, 5, and 7 at 3 months after intervention. Semi-structured interview data indicated improvement in all five dimensions of cognitive function, quality of life, depression, loneliness, and self-efficacy of the subjects.

For older adults with mild cognitive impairment, it is of great significance to perform a non-pharmacological integrated intervention in terms of cognitive training, physical exercise, emotional management, social connection, and healthy lifestyle habits. The MoCA, SF-12, GDS-15, and DJGLS scores of older adults with mild cognitive impairment improved at 3 months of intervention, while the GSES scores improved at 3 months after intervention. GSES scores were not as effective after the intervention. All dimension scores showed a decreasing trend at 3 months after the intervention.

认知障碍可导致老年人认知功能下降、抑郁、孤独感，以及自我效能感和生活质量的下降。

探讨非药物整合式干预对轻度老年认知障碍患者认知功能、抑郁、孤独感、自我效能感和生活质量的干预效果。

基于认知障碍的风险因素研发了认知功能训练、身体运动、情绪管理、社会连结、健康生活习惯5个维度的非药物整合式干预方案，采用A-B-A单个案受试者设计，于2021年6—12月展开对3名确诊为轻度认知障碍的老年人进行为期3个月，1次/周，60 min/次的干预。于基线、干预3个月后、干预结束后3个月时采用蒙特利尔认知评估量表（MoCA）、自我效能感量表（GSES）、简版生活质量量表（SF-12）、简版老年抑郁量表（GDS-15）、中文版孤独量表（DJGLS）从认知功能、自我效能感、生活质量、抑郁情绪、孤独感5个维度评估3名老年人各量表得分并分析其变化。并在干预结束后3个月进行半结构式访谈，从认知功能、生活质量、抑郁情绪、自我效能感和孤独感维度评估干预效果。

纳入研究的3名老年人年龄为74、70、73岁，均已婚、与配偶和孙辈共同居住。3名老年人的MoCA基线得分为21、22、24分，干预3个月后为28、26、27分，干预结束后3个月为25、19、23分；GSES基线得分为25、30、27分，干预3个月后为29、29、30分，干预结束后3个月为28、31、28分。SF-12基线时得分为69、32、51分，干预3个月后为81、81、83分，干预结束后3个月为78、38、59分。GDS-15基线得分为4、8、2分，干预3个月后为2、6、1分，干预结束后3个月为1、8、4分。DJGLS基线得分为8、7、8分，干预3个月后为5、5、4分，干预结束后3个月为5、5、7分。半结构访谈资料表明，受试者在认知功能、生活质量、抑郁情绪、孤独感、自我效能感5个维度均有改善。

对于患有轻度老年认知障碍的受试老年人而言，从认知功能训练、身体运动、情绪调节、社会连结、健康生活习惯5个维度开展非药物整合式的干预是有意义的，轻度老年认知障碍老年人的MoCA、SF-12、GDS-15、DJGLS得分在干预3个月后均有改善，GSES得分在干预后效果不理想，所有维度得分在干预结束后3个月呈递减趋势。