Abstract:

Bronchial asthma is a chronic inflammatory disease with high heterogeneity, polygenic inheritance, complex etiology and many complications. The effects of prevention and treatment for a bronchial asthma patient often depend on whether the patient has received a personalized health management. In order to be in line with the international management level of bronchial asthma, the updates in the 2018 Guideline for the Diagnosis and Management of Bronchial Asthma in Primary Care (Practice Edition, here in after referred to as the 2018 Guideline) contain the idea of early intervention, optimized medication regimens, and highlighted standardized management approach regarding bronchial asthma. To promote personalized pharmacologic management of bronchial asthma in primary care, and to provide online pre-, mid- and post-diagnosis pharmaceutical services for physicians, as well as personalized pharmacologic monitoring and management services for bronchial asthma patients in the community, pharmacists have developed a search engine with integrated functions of "pre-judgment, early warning and prediction" to collect medication information related to bronchial asthma using the information technology, according to the pharmacologic treatment path "initial treatment, long-term treatment, degradation principle" put forward in the 2018 Guideline, with the "one factory, one drug, one specification" individualized instruction as a basis.

Key words: Bronchial asthma, Guideline, Antiasthmatic medication, Knowledge base, Personalized, Intelligent

摘要：

支气管哮喘是一种气道慢性炎性、高度异质性、多基因遗传性疾病，病因复杂，合并症多，防治效果常取决于是否进行了个体化的健康管理。为了与国际接轨，更新的《支气管哮喘基层诊疗指南（实践版·2018年版）》提出了哮喘早期干预思路，优化了哮喘用药方案，强化了哮喘规范化管理理念。为了推进基层哮喘个体化用药管理，本研究参照新版指南中的药物治疗路径"初始治疗、长期治疗方案、降级治疗原则"，以"一厂、一品、一规"个性化说明书为基础，通过信息技术数字化采集用药知识，构建了"预判、预警、预知"功能的搜索引擎，为医师提供诊前、诊中、诊后的线上服务，实现为社区患者提供哮喘个体化用药监测与管理。

关键词: 支气管哮喘, 指南, 平喘用药, 知识库, 个体化, 智能化