Abstract: Background　Cytokine hypothesis is one of the most important theories of the mechanism of depression.Numerous studies have suggested that childhood trauma was closely relevant to the occurrence of depression.Knowing the relationship of serum indices，and childhood trauma with depression might provide a theoretical basis for further studies of the pathogenesis.Objective　To investigate the relationships of serum CRP，IP-10，TGF-β1 levels and childhood trauma with the risk of adulthood depression.Methods　A case-control study design was adopted in this study with 48 adult patients with depression and 51 healthy adult controls from Mental Health Department，The Second Affiliated Hospital of Guangxi Medical University were included during May 2018 to May 2019.Serum CRP，IP-10 and TGF-β1 levels were measured by double-antibody sandwich ELISA.The 28-item Childhood Trauma Questionnaire-Short Form was used to assess childhood trauma.Multivariate Logistic regression was used to identify the risk factors of adulthood depression.Results　Compared with control group，the case group showed significantly lower average level of TGF-β 1（P<0.01），and higher scores of emotional abuse，physical abuse，sexual abuse and emotional neglect（P<0.05）.Logistic regression analysis showed that lower level of serum TGF-β1，low level of serum TGF-β1，emotional abuse，physical abuse，sexual abuse and emotional neglect increased the risk of depression（OR=5.60，7.86，11.20，7.62，4.43，3.34，P<0.05）.Conclusion　Serum TGF-β1 levels and childhood trauma experience might have impact on the risk of depression in adulthood.

Key words: Depressive disorder, Transforming growth factor beta1, C-reactive protein , Interferon-inducible protein-10, Childhood trauma, Case-control studies

摘要： 背景　细胞因子假说是抑郁症的重要发病机制学说之一，目前也有大量研究发现抑郁症的发病与童年期的创伤经历有密切关系，了解其对抑郁症发病的影响，为抑郁症发病机制研究进一步提供理论参考依据。目的　探讨血清C反应蛋白（CRP）、干扰素诱导蛋白10（IP-10）、转化生长因子β1（TGF-β1）水平和童年期创伤与抑郁症发病风险的关系。方法　选取2018年5月—2019年5月在广西医科大学第二附属医院心理卫生科就诊的47例抑郁症患者作为病例组，同期在该医院体检部招募健康志愿者51例作为对照组。以双抗体夹心法酶联免疫吸附试验（ELISA）测定血清CRP、IP-10、TGF-β1水平，应用28项简版童年期创伤问卷（CTQ-SF）评估研究对象童年期创伤情况。采用多因素Logistic回归分析探讨抑郁症发病风险因素。结果　病例组血清TGF-β1水平低于对照组（P<0.01）。病例组情感虐待得分、躯体虐待得分、性虐待得分、情感忽视得分高于对照组（P<0.05）。多因素Logistic回归分析结果显示，较低水平TGF-β1（OR=5.60，P<0.05）和低水平TGF-β1（OR=7.86，P<0.05）、情感虐待阳性（OR=11.20，P<0.05）、躯体虐待阳性（OR=7.62，P<0.05）、性虐待阳性（OR=4.43，P<0.05）以及情感忽视阳性（OR=3.34，P<0.05）可能为抑郁症发病的危险因素。结论　血清TGF-β1水平、童年期创伤经历可能对抑郁症发病的风险有影响。

关键词: 抑郁症, 转化生长因子&beta, 1, C反应蛋白, 干扰素诱导蛋白10, 童年期创伤, 病例对照研究