Rational Application of Antipsychotics in Pregnancy

doi:10.12114/j.issn.1007-9572.2019.00.223

Abstract

Abstract: The effect of medication in pregnancy on maternal health and fetal growth and development has aroused wide concern.However，due to limits of medical ethics and other factors，it is difficult to conduct an in-depth scientific research on medication during pregnancy.Schizophrenia is a chronic mental disease whose prevalence rate is increasing year by year.In particular，it is highly prevalent in those aged 25-35 years old，and women of this age group are in the ‘right' age to have a baby.In addition，treating emotional disorders and other psychiatric disorders associated with pregnancy，also may involve the use of antipsychotics.Antipsychotics can affect the fetus through the placenta，cause perinatal syndrome，even severe fetal malformations，and may also affect long-term neurobehavior.Likewise，untreated mental symptoms also affect the pregnant woman and the fetus.Therefore，the safety and necessity of appropriate use of antipsychotics during pregnancy have become a clinical problem that needs to be solved urgently.This paper mainly discusses the rational application of antipsychotics in pregnancy，in order to provide help for clinicians in formulating medication treatment plan for mental disorders during pregnancy.

Key words: Pregnancy, Antipsychotic agents, Fetal development, Physiological effects of drugs

摘要： 妊娠期用药对于母体健康和胎儿生长发育的影响备受关注。然而妊娠期用药受伦理学等多方面因素的限制，难以进行科学的深入研究。精神分裂症是一种慢性精神疾病，患病率逐年上升，其高发年龄为25~35岁，同样也是女性的适宜生育年龄。此外，情感障碍等其他妊娠期精神障碍可能涉及抗精神病药物的使用。抗精神病药物可以通过胎盘对胎儿造成影响，如围生期综合征，重者可致胎儿畸形，对新生儿后期的神经行为也可能产生影响。未经治疗的精神症状本身也会对妊娠期妇女和胎儿造成影响，因此患有精神障碍的妇女妊娠期抗精神病药物应用的安全性及必要性成为临床治疗亟待解决的问题。本文主要就妊娠期抗精神病药物的合理应用进行详述，以期为临床医师制定妊娠期精神障碍的用药治疗方案提供帮助。

关键词: 妊娠, 抗精神病药, 胎儿发育, 药物生理作用

ZHAI Qian,ZHANG Guofu,LIU Min, et al. Rational Application of Antipsychotics in Pregnancy　[J]. Chinese General Practice, 2019, 22(30): 3701-3708. DOI: 10.12114/j.issn.1007-9572.2019.00.223.
翟倩,张国富,刘敏等. 妊娠期抗精神病药物的合理应用[J]. 中国全科医学, 2019, 22(30): 3701-3708. DOI: 10.12114/j.issn.1007-9572.2019.00.223.

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