
Chinese General Practice ›› 2016, Vol. 19 ›› Issue (35): 4408-4412.DOI: 10.3969/j.issn.1007-9572.2016.35.024
Published:2016-12-15
Online:2026-01-28
基金资助:LI Xiao-jun, WANG Ming-hang, LI Su-yun. Research Progress of Risk Early-warning Factors of Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. Chinese General Practice, 2016, 19(35): 4408-4412.
李晓俊, 王明航, 李素云. 慢性阻塞性肺疾病急性加重风险预警因子研究进展[J]. 中国全科医学, 2016, 19(35): 4408-4412.
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| [1]中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中国医学前沿杂志(电子版),2014,6(2):67-80. Chronic Obstructive Pulmonary Disease Committee,Respiratory Society,Chinese Medical Association.Guide for the diagnosis,treatment of chronic obstructive pulmonary disease(revised 2013)[J].Chinese Journal of the Frontiers of Medical Science(Electronic Version),2014,6(2):67-80. [2]SU B,LIU T,FAN H J,et al.Inflammatory markers and the risk of chronic obstructive pulmonary disease:a systematic review and meta-analysis[J].PLoS One,2016,11(4):e0150586. [3]FATTOUH M,ALKADY O.Inflammatory biomarkers in chronic obstructive pulmonary disease[J].Egypt J Chest Dis Tuberc,2014,63(4):799-804. [4]徐英,高滨,崔晓媛,等.吸烟人群肺功能以及血IL-8和C反应蛋白的变化趋势与发生COPD高风险研究[J].中国现代药物应用,2016,10(6):78-79. XU Y,GAO B,CUI X Y,et al.The lung function and the change trend of IL-8 and C reactive protein in smokers and the high risk of COPD[J].Chinese Journal of Modern Drug Application,2016,10(6):78-79. [5]NURAL S,GNAY E,HALICI B,et al.Inflammatory processes and effects of continuous positive airway pressure(CPAP) in overlap syndrome[J].Inflammation,2013,36(1):66-74. [6]ALBRICH W C,DUSEMUND F,BUCHER B,et al.Effectiveness and safety of procalcitonin-guided antibiotic therapy in lower respiratory tract infections in "real life":an international,multicenter poststudy survey(Pro REAL)[J].Arch Intern Med,2012,172(9):715-722. [7]LACOMA A,PRAT C,ANDREO F,et al.Value of procalcitonin,C-reactive protein,andneopterin in exacerbations of chronic obstructive pulmonary disease[J].Int J Chron Obstruct Pulmon Dis,2011,6:157-169. [8]FALSEY A R,BECKER K L,SWINBURNE A J,et al.Utility of serum procalcitonin values in patients with acute exacerbations of chronic obstructive pulmonary disease:a cautionary note[J].Int J Chron Obstruct Pulmon Dis,2012,7:127-135. [9]WANG J X,ZHANG S M,LI X H,et al.Acute exacerbations of chronic obstructive pulmonary disease with low serum procalcitonin values do not benefit from antibiotic treatment:a prospective randomized controlled trial[J].Int J Infect Dis,2016,48:40-45. [10]TANRIVERDI H,RNEK T,ERBOY F,et al.Comparison of diagnostic values of procalcitonin,C-reactive protein and blood neutrophil/lymphocyte ratio levels in predicting bacterial infection in hospitalized patients with acute exacerbations of COPD[J].Wien Klin Wochenschr,2015,127(19/20):756-763. [11]张艳平,周鹂婕.C-反应蛋白联合降钙素原对慢性阻塞性肺病急性加重期中细菌感染的诊疗价值[J].中南大学学报(医学版),2014,39(9):939-943. ZHANG Y P,ZHOU L J.Diagnostic value of C-reactive protein and procalcitonin for bacterial infection in acute exacerbations of chronic obstructive pulmonary disease[J].Journal of Central South University(Medical Science),2014,39(9):939-943. [12]KEATINGS V M,COLLINS P D,SCOTT D M,et al.Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma[J].Am J Respir Crit Care Med,1996,153(2):530-534. [13]CHEN L,SUN B B,WANG T,et al.Cigarette smoke enhances β-defensin 2 expression in rat airways via nuclear factor-κB activation[J].Eur Respir J,2010,36(3):638-645. [14]梁卫娟,华锋.CRP和TNF-α在慢阻肺急性加重期病情严重程度判断中的意义[J].中国现代医生,2015,53(9):12-15. LIANG W J,HUA F.Significance of CRP and TNF-α in judgment of severity of AECOPD[J].China Modern Doctor,2015,53(9):12-15. [15]LAINSCAK M,VON HAEHLING S,DOEHNER W,et al.Body mass index and prognosis in patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease[J].J Cachexia Sarcopenia Muscle Muscle,2011,2(2):81-86. [16]陆梅,李泽庚,朱洁,等.COPD合并营养不良状况的相关研究进展[J].光明中医,2016,31(2):296-298. LU M,LI Z G,ZHU J,et al.Research progress of COPD combined with malnutrition[J].Guangming Journal of Chinese Medicine,2016,31(2):296-298. [17]BOUTOU A K,KARRAR S,HOPKINSON N S,et al.Anemia and survival in chronic obstructive pulmonary disease:a dichotomous rather than a continuous predictor[J].Respiration,2013,85(2):126-131. [18]SHARMA R K,CHAKRABARTI S.Anaemia secondary to erythropoietin resistance:important predictor of adverse outcomes in chronic obstructive pulmonary disease[J].Postgrad Med J,2016.[Epub ahead of print]. [19]MARTINEZ-RIVERA C,PORTILLO K,MUOZ-FERRER A,et al.Anemia is a mortality predictor in hospitalized patients for COPD exacerbation[J].COPD,2012,9(3):243-250. [20]RAHIMI-RAD M H,SADIGHI T,RABIEEPOUR M,et al.Prevalence of anemia and its impact on mortality in patients with acute exacerbation of chronic obstructive pulmonary disease in a developing country setting [J].Pneumologia,2015,64(3):27-30. [21]TSURUTA R,KAWAMURA Y,INOUE T,et al.Corticosteroid therapy for hemolytic anemia and respiratory failure due to Mycoplasma pneumoniae pneumonia[J].Intern Med,2002,41(3):229-232. [22]ULUBAY G,ULASLI S S,BOZBAS S S,et al.Effects of peripheral neuropathy on exercise capacity and quality of life in patients with chronic obstructive pulmonary diseases[J].Arch Med Sci,2012,8(2):296-302. [23]VARRASO R,CAMARGO C A Jr.More evidence for the importance of nutritional factors in chronic obstructive pulmonary diseases[J].Am J Clin Nutr,2012,95(6):1301-1302. [24]程云,陈荣全.慢性阻塞性肺疾病患者营养不良的现状[J].南通大学学报(医学版),2013,33(6):586-587. CHENG Y,CHEN R Q.The status of malnutrition in patients with chronic obstructive pulmonary disease[J].Journal of Nantong University(Medical Sciences),2013,33(6):586-587.DOI:10.3969/j.issn.1005-9202.2015.01.099. [25]HERSELMAN M,ESAU N,KRUGER J M,et al.Relationship between serum protein and mortality in adults on long-term hemodialysis:exhaustive review and meta-analysis[J].Nutrition,2010,26(1):10-32. [26]TAKAYA Y,KUMASAKA R,ARAKAWA T,et al.Impact of cardiac rehabilitation on renal function in patients with and without chronic kidney disease after acute myocardial infaction[J].Circ J,2014,78(2):377-384. [27]SANGARALINGHAM S J,BURNETT J C Jr,MCKIE P M,et al.Rationale and design of a randomized,double-blind,placebo-controlled clinical trial to evaluate the efficacy of B-type natriuretic peptide for the preservation of left ventricular function[J].J Card Fail,2013,19(8):533-539. [28]OTA H,TSKEUCHI T,SATO N,et al.Diostick proteinuria as a surrogate maker of lomg-term motality after acute myocardial infaction[J].J Cardiol,2013,62(5):277-282. [29]TAYLAN M,DEMIR M,KAYA H,et al.Alterations of the neutrophIL-lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients[J].Clin Respir J,2015.[Epub ahead of print]. [30]GNAY E,SARINC U S,AHAR O,et al.NeutrophIL-to-lymphocyte ratio in chronic obstructive pulmonary disease:a retrospective study[J].Inflammation,2014,37(2):374-380. [31]VALIPOUR A,SCHREDER M,WOLZT M,et al.Circulating vascular endothelial growth factor and systemic inflammatory markers in patients with stable and exacerbated chronic obstructive pulmonary disease[J].Clin Sci(Lond),2008,115(7):225-232. [32]SALA E,VILLENA C,BALAGUER C,et al.Abnormal levels of circulating endothelial progenitor cells during exacerbations of COPD[J].Lung,2010,188(4):331-338. [33]樊淑青.血管内皮因子在AECOPD老年患者病情诊断评估中的临床意义[J].临床肺科杂志,2015,20(1):62-64. FAN S Q.Clinical significance of vascular endothelial factor in the assessment of AECOPD patients[J].Journal of Clinical Pulmonary Medicine,2015,20(1):62-64. [34]王垚,杨红燕,冯俐.血栓弹力图早期判断COPD急性加重期的凝血异常[J].实用老年医学,2014,28(11):956-957. WANG Y,YANG H Y,FENG L.Early judgment of coagulation abnormalities in acute exacerbation of COPD by thrombelastogram[J].Practical Geriatrics,2014,28(11):956-957. [35]ABROUG F,OUANES B L,NCIRI N,et al.Association of left-heart dysfunction with severe exacerbation of chronic obstructive pulmonary disease:diagnostic performance of cardiac biomarkers(2006)[J].Am J Respir Crit Care Med,2006,174(9):990-996. [36]HUANG Y S,FENG Y C,ZHANG J,et al.Impact of chronic obstructive pulmonary diseases on left ventricular diastolic function in hospitalized elderly patients[J].Clin Interv Aging,2014,10:81-87. [37]张明,彭夏莹,刘守智,等.慢性阻塞性肺疾病急性加重患者肺动脉与主动脉直径比>1和血浆尿钠肽、C反应蛋白、白细胞介素6的相关性分析[J].中国呼吸与危重监护杂志,2015,14(3):255-259. ZHANG M,PENG X Y,LIU S Z,et al.The relecance of the ratio of pulmonary arterial diameter to aortic diameter exceeding one with brain natriuretic peptide and inflammatory factors in patients with acute exacerbation of COPD[J].Chinese Journal of Respiratory and Critical Care Medicine,2015,14(3):255-259. [38]姚婉贞,路明.2015年新版GOLD报告要点解读[J].浙江医学,2015(5):354-356. YAO W Z,LU M.Interpretation of the new version of the GOLD report in 2015[J].Zhejiang Medical Journal,2015(5):354-356. [39]CARLIN B W.COPD and associated comorbidities:a review of current diagnosis and treatment[J].Postgrad Med,2012,124(4):225-240. [40]庞红燕,杨汀,王辰,等.2016年更新版GOLD慢性阻塞性肺疾病诊断、治疗和预防的全球策略简介[J].中国医学前沿杂志(电子版),2016,8(7):28-32. PANG H Y,YANG T,WANG C,et al.Global strategy for the diagnosis,treatment and prevention of chronic obstructive pulmonary disease in the updated version of GOLD in 2016[J].Chinese Journal of the Frontiers of Medical Science(Electronic Version),2016,8(7):28-32. [41]GUDMUNDSSON G,GISLASON T,JANSON C,et al.Risk factors forrehospitalisation in COPD:role of health status,anxiety anddepression[J].Eur Respir J,2005,26(3):414-419. [42]杜晓秋,周军,张秋娣.不同评价指标在慢性阻塞性肺疾病患者综合评估中的应用[J].中国全科医学,2016,19(5):511-516. DU X Q,ZHOU J,ZHANG Q D.Application of different evaluation indexes in the comprehensive assessment of patients with chronic obstructive pulmonary disease[J].Chinese General Practice,2016,19(5):511-516. [43]常小红,雷莲莲,王莉.老年男性慢性阻塞性肺疾病合并焦虑抑郁状态临床研究[J].临床荟萃,2014,29(1):41-44. CHANG X H,LEI L L,WANG L.Clinical study on elderly male patients of chronic obstructive pulmonary disease with anxiety and depression[J].Clinical Focus,2014,29(1):41-44. [44]王琼娅,乐文卿,余浩.APACHEⅡ评分和CAPS评分在慢性阻塞性肺疾病急性加重期合并呼吸衰竭患者预后评估的应用[J].实用临床医药杂志,2016,20(11):25-26. WANG Q Y,YUE W Q,YU H.Application of APACHE Ⅱ score and CAPS score in prognostic evaluation of patients with AECOPD complicated with respiratory failure[J].Journal of Clinical Medicine in Practice,2016,20(11):25-26. [45]SHORR A F,SUN X W,JOHANNES R S,et al.Predicting the need for mechanical ventilation in acute exacerbations of chronic obstructive pulmonary disease:comparing the CURB-65 and BAP-65 scores[J].J Crit Care,2012,27(6):564-570. [46]LOKE Y K,KWOK C S,NIRUBAN A,et al.Value of severity scales in predicting mortality from community-acquired pneumonia:systematic review and meta-analysis[J].Thorax,2010,65(10):884-890. [47]CHALMERS J D,SINGANAYAGAM A,AKRAM A R,et al.Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia.Systematic review and meta-analysis[J].Thorax,2010,65(10):878-883. [48]CHANG C L,SULLIVAN G D,KARALUS N C,et al.Predicting early mortality in acute exacerbation of chronic obstructive pulmonary disease using the CURB65 score[J].Respirology,2011,16(1):146-151. [49]HU G,ZHOU Y,WU Y,et al.The pneumonia severity index as a predictor of in-hospital mortality in acute exacerbation of chronic obstructive pulmonary disease[J].PLoS One,2015,10(7):e0133160. [50]蒋云,崔妙玲,杨祺,等.BAP-65和CURB-65评分预测AECOPD患者行机械通气的研究[J].临床肺科杂志,2015,20(2):262-264. JIANG Y,CUI M L,YANG Q,et al.BAP-65 and CURB-65 scores in prediction need for mechanical ventilation in patients with AECOPD[J].Journal of Clinical Pulmonary Medicine,2015,20(2):262-264. |
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